“…Puzzle game-based learning has many applications in the elds of computer education (30),chemistry (31),anatomy (32),pharmacology (33),physiology (20,34),pathology (21,25),neurosurgery (35)and mathematics(36).Decision Sciences Institute considers "puzzle-based learning as a precursor to critical thinking and problem solving" (30,37).According to Mishalevich,puzzles must follow at least one of the criteria of generality(providing the player with the ability to solve real problems in the future),simplicity(the puzzle and its solution are easily recorded in the player's memory),entertainment(encouraging the player's interest in solving the puzzle)and Eureka(each piece must be placed in its own place and after placement, the player must be given immediate feedback and reward)(38).The bene ts of puzzle game-based training can be pointed out the transformation of passive learners into active ones,promotion of interest,satisfaction and academic function,promotion of critical thinking skills and problem solving in other elds of real life instead of content coverage,encouragement to analogical and clinical reasoning, general stimulation to use application of learned knowledge and their combination,increasing concentration and stimulation of comprehensive memory to consolidate and better understand concepts,highlighting main concepts,acquiring cognitive skills,improving executive function(due to the need to formulate strategies, rearrange and plan),transform the training process from trainer-centered to learnercentered (16,19,21,25,26,30,(39)(40)(41)(42). Cardozo et al(2021)found that,according to students, the online digital version of the heart cycle puzzle is useful for their learning (20).…”