The CRF1 receptor antagonist, NBI-35965, abolished the activation of locus coeruleus neurons induced by colorectal distension and intracisternal CRF in rats

Kosoyan, Hovsep P.; Grigoriadis, Dimitri E.; Taché, Yvette

doi:10.1016/j.brainres.2005.07.010

Cited by 34 publications

(35 citation statements)

References 53 publications

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“…Infusion of CRF1 antagonist into the CeA attenuates the hypersensitivity to colonic distension in the WKY rats, thus confirming the role of CRF1 receptor in the amygdala in VHS mechanism (Johnson, et al 2012). The basal expression of CRF in the LC is increased in WKY rats and a selective CRF1 receptor antagonist abolished the activation of LC neurons by colorectal distension and intracisternal CRF in rats (Kosoyan, et al 2005). These data strengthen the role of the CeA and LC in VHS through CRF1 which is in agreement with the interactions between both nuclei involved in emotional-arousal circuit.…”

Section: Amygdala and Visceral Hyperalgesiasupporting

confidence: 59%

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

Bonaz¹,

Pellissier²,

Sinniger³

et al. 2012

The Amygdala - A Discrete Multitasking Manager

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Section: Amygdala and Visceral Hyperalgesiasupporting

confidence: 59%

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

Bonaz¹,

Pellissier²,

Sinniger³

et al. 2012

The Amygdala - A Discrete Multitasking Manager

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“…CRF receptors are present in the LC (45), and activation of LC neurons by low levels of colonic distension are mediated by CRF release from the BN within the LC, whereas activation elicited by higher magnitudes of distension involve other mediators, such as glutamate (26). A recent report revealed the involvement of CRF 1 in the increased spontaneous discharge rate of LC neurons induced by intracisternal injection of CRF or phasic CRD of 45 mmHg in anesthetized rats (24). These data are in agreement with our results and support the involvement of the CRF 1 system only for low volumes of distensions (40 mmHg in our study).…”

Section: Discussionmentioning

confidence: 99%

Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats

Larauche¹,

Bradesi²,

Million³

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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Larauche M, Bradesi S, Million M, McLean P, Taché Y, Mayer EA, McRoberts JA. Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats. Am J Physiol Gastrointest Liver Physiol 294: G1033-G1040, 2008. First published February 28, 2008 doi:10.1152/ajpgi.00507.2007.-Visceral hypersensitivity has been implicated as an important pathophysiological mechanism in functional gastrointestinal disorders. In this study, we investigated whether the sustained visceral hyperalgesia induced by repeated psychological stress in rats involves the activation of CRF1 signaling system using two different antagonists. Male Wistar rats were exposed to 10 consecutive days of water avoidance stress (WAS) or sham stress for 1 h/day, and the visceromotor response to phasic colorectal distension (CRD) was assessed before and after the stress period. Animals were injected subcutaneously with the brain penetrant CRF 1 antagonist, CP-154,526, acutely (30 min before the final CRD) or chronically (via osmotic minipump implanted subcutaneously, during stress) or with the peripherally restricted, nonselective CRF1 and CRF2 antagonist, astressin, chronically (15 min before each stress session). Repeated WAS induced visceral hypersensitivity to CRD at 40 and 60 mmHg. CP-154,526 injected acutely significantly reduced stress-induced visceral hyperalgesia at 40 mmHg but not at 60 mmHg. Chronic subcutaneous delivery of astressin reduced the stress-induced visceral hyperalgesia to baseline at all distension pressures. Interestingly, chronically administered CP-154,526 eliminated hyperalgesia and produced responses below baseline at 40 mmHg and 60 mmHg, indicating a hypoalgesic effect of the compound. These data support a major role for CRF1 in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms. visceral nociception; astressin; CP-154,526; water avoidance

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“…For example, norepinephrine release in ascending pathways from the locus coeruleus during pain stimuli, such as rectal distention (28,30), have been proposed to increase the signal-to- noise ratio in target regions by inhibiting neuronal activity in areas around the excitation (54). The administration of opioid agonists has recently been shown to increase the BOLD-fMRI signal in all of the pain-associated regions we assessed in this report (32).…”

Section: Possible Mechanisms Underlying Bold Signal Decreasesmentioning

confidence: 97%

Sex differences in regional brain response to aversive pelvic visceral stimuli

Berman

Naliboff²,

Suyenobu³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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To explore sex differences in the response of seven brain regions to an aversive pelvic visceral stimulus, functional magnetic resonance images were acquired from 13 healthy adults (6 women) during 15 s of cued rectal distension at two pressures: 25 mmHg (uncomfortable), and 45 mmHg (mild pain), as well as during an expectation condition (no distension). Randomeffects analyses combining subject data voxelwise found 45-mmHg pressure significantly activated the insular and anterior cingulate cortices in both sexes. In men only, the left thalamus and ventral striatum were also activated. Although all activations appeared more extensive in men, no sex difference attained significance. To explore the presence of deactivations, which are generally cancelled by more numerous activations when subjects are combined for each voxel, the number of activated voxels, number of deactivated voxels, and ratio of deactivated voxels to total voxels affected were assessed via randomeffects, mixed-model analyses combining subject data at the region level. Greater insula activation in men compared with women was seen during the expectation condition and during the 25-mmHg distension. Greater deactivations in women were seen in the amygdala (25-mmHg distension) and midcingulate (45-mmHg distension). Women had a significantly higher proportion of deactivated voxels than men in all four subcortical structures during 25-mmHg distension. Greater familiarity of females with physiological pelvic visceral discomfort may have enhanced brain systems that dampen arousal networks during lower levels of discomfort. functional magnetic resonance imaging; brain imaging; pain CONSIDERABLE EPIDEMIOLOGICAL and experimental evidence suggests that men and women respond to pain differently in terms of perceptual and autonomic nervous system responses. Epidemiological data indicate that compared with men, women are overrepresented in many, but not all, chronic pain disorders, including fibromyalgia, migraine, interstitial cystitis, and functional gastrointestinal disorders, such as irritable bowel syndrome (IBS) (59). For example, women are more likely to suffer from IBS, develop the so-called postinfectious IBS, and develop comorbidities such as fibromyalgia or interstitial cystitis (36). A variety of mechanisms have been proposed to explain these sex differences, including differences in the response of the central nervous system to pelvic visceral stimuli.Despite the similarity between sex differences in somatic and visceral pain prevalence in epidemiological and diseaserelated studies, the results of experimental pain studies with the two types of pain stimuli differ. Consistent with the epidemiological data, women have greater sensitivity and less tolerance to somatic pain stimuli (52). In contrast, the majority of studies using controlled rectal balloon distension (a frequently used pelvic visceral pain stimulus), to date, have not shown significant sex-related differences in pain or discomfort thresholds in either controls or IBS patients (26,37,42...

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The CRF1 receptor antagonist, NBI-35965, abolished the activation of locus coeruleus neurons induced by colorectal distension and intracisternal CRF in rats

Cited by 34 publications

References 53 publications

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

The Irritable Bowel Syndrome: How Stress Can Affect the Amygdala Activity and the Brain-Gut Axis

Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats

Sex differences in regional brain response to aversive pelvic visceral stimuli

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