The critical role of piperamide derivative D4 in the regulation of inflammatory response by the microglia and astrocytic glial cells

Shahbazi, Sajad; Zakerali, Tara; Frycz, Bartosz Adam; Kaur, Jagdeep

doi:10.1016/j.biopha.2020.110895

Cited by 8 publications

(5 citation statements)

References 45 publications

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“…Furthermore, piperine derivatives, such as (2E,4E)-5-(benzo[d] [1,3]dioxo l-5-yl)-N- [4-(hydroxymethyl) phenyl] penta-2,4-dienamide (D4) have demonstrated anti-neuroinflammatory effects (60) by inhibiting the translocation of NF-κB and suppressing the expression of iNOS and the secretion of NO, TNF-α, and IL-1β in LPS-induced human microglia clone 3. In addition, an in silico study showed excellent d4 bioavailability after oral administration (61). Bupleurum falcatum L. (BF) is a traditional oriental medicine commonly used in the treatment of chronic hepatitis and autoimmune diseases (62).…”

Section: Nf-κb (Nuclear Factor-kappa-b)mentioning

confidence: 99%

Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review)

Zheng,

Zhang,

Zhang

et al. 2023

Int J Mol Med

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The intricate nature of Alzheimer's disease (AD) pathogenesis poses a persistent obstacle to drug development. In recent times, neuroinflammation has emerged as a crucial pathogenic mechanism of AD, and the targeting of inflammation has become a viable approach for the prevention and management of AD. The present study conducted a comprehensive review of the literature between October 2012 and October 2022, identifying a total of 96 references, encompassing 91 distinct pharmaceuticals that have been investigated for their potential impact on AD by inhibiting neuroinflammation. Research has shown that pharmaceuticals have the potential to ameliorate AD by reducing neuroinflammation mainly through regulating inflammatory signaling pathways such as NF-κB, MAPK, NLRP3, PPARs, STAT3, CREB, PI3K/Akt, Nrf2 and their respective signaling pathways. Among them, tanshinone IIA has been extensively studied for its anti-inflammatory effects, which have shown significant pharmacological properties and can be applied clinically. Thus, it may hold promise as an effective drug for the treatment of AD. The present review elucidated the inflammatory signaling pathways of pharmaceuticals that have been investigated for their therapeutic efficacy in AD and elucidates their underlying mechanisms. This underscores the auspicious potential of pharmaceuticals in ameliorating AD by impeding neuroinflammation.

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Section: Nf-κb (Nuclear Factor-kappa-b)mentioning

confidence: 99%

Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review)

Zheng,

Zhang,

Zhang

et al. 2023

Int J Mol Med

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“…Neuroinflammation can induce mitochondrial dysfunction. The main feature is that these reactive glial cells produce nitric oxide (NO) as well as reactive oxygen species (ROS) [5]. Both mutually influencing pathogeneses, inflammation, mitochondrial dysfunction, and eventually neuronal function of the CNS [6,7].…”

Section: Prefacementioning

confidence: 99%

Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases

Kung

Lin

2021

IJMS

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Neuroinflammation and abnormal mitochondrial function are related to the cause of aging, neurodegeneration, and neurotrauma. The activation of nuclear factor κB (NF-κB), exaggerating these two pathologies, underlies the pathogenesis for the aforementioned injuries and diseases in the central nervous system (CNS). CDGSH iron-sulfur domain 2 (CISD2) belongs to the human NEET protein family with the [2Fe-2S] cluster. CISD2 has been verified as an NFκB antagonist through the association with peroxisome proliferator-activated receptor-β (PPAR-β). This protective protein can be attenuated under circumstances of CNS injuries and diseases, thereby causing NFκB activation and exaggerating NFκB-provoked neuroinflammation and abnormal mitochondrial function. Consequently, CISD2-elevating plans of action provide pathways in the management of various disease categories. Various bioactive molecules derived from plants exert protective anti-oxidative and anti-inflammatory effects and serve as natural antioxidants, such as conjugated fatty acids and phenolic compounds. Herein, we have summarized pharmacological characters of the two phytochemicals, namely, alpha-eleostearic acid (α-ESA), an isomer of conjugated linolenic acids derived from wild bitter melon (Momordica charantia L. var. abbreviata Ser.), and curcumin, a polyphenol derived from rhizomes of Curcuma longa L. In this review, the unique function of the CISD2-elevating effect of α-ESA and curcumin are particularly emphasized, and these natural compounds are expected to serve as a potential therapeutic target for CNS injuries and diseases.

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“…The role of the piperamide derivative D4 in neurodegenerative diseases has recently been discovered [ 226 ]. Human immortalized astrocytes (SVG) and human immortalized microglial cells (CHME3) were pretreated with D4 and aspirin (Asp) for 2 h followed by post-treatment with LPS.…”

Section: Natural Compounds As Ppar Agonistsmentioning

confidence: 99%

Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders

2021

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Peroxisome proliferator-activated receptors (PPAR-γ, PPAR-α, and PPAR-β/δ) are ligand-dependent nuclear receptors that play a critical role in the regulation of hundreds of genes through their activation. Their expression and targeted activation play an important role in the treatment of a variety of diseases, including neurodegenerative, cardiovascular, diabetes, and cancer. In recent years, several reviews have been published describing the therapeutic potential of PPAR agonists (natural or synthetic) in the disorders listed above; however, no comprehensive report defining the role of naturally derived phytoconstituents as PPAR agonists targeting neurodegenerative diseases has been published. This review will focus on the role of phytoconstituents as PPAR agonists and the relevant preclinical studies and mechanistic insights into their neuroprotective effects. Exemplary research includes flavonoids, fatty acids, cannabinoids, curcumin, genistein, capsaicin, and piperine, all of which have been shown to be PPAR agonists either directly or indirectly. Additionally, a few studies have demonstrated the use of clinical samples in in vitro investigations. The role of the fruit fly Drosophila melanogaster as a potential model for studying neurodegenerative diseases has also been highlighted.

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The critical role of piperamide derivative D4 in the regulation of inflammatory response by the microglia and astrocytic glial cells

Cited by 8 publications

References 45 publications

Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review)

Inflammatory signaling pathways in the treatment of Alzheimer's disease with inhibitors, natural products and metabolites (Review)

Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases

Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders

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