The cross-talk between tumor-associated macrophages and tumor endothelium: Recent advances in macrophage-based cancer immunotherapy

Baradaran, Ali; Asadzadeh, Zahra; Hemmat, Nima; Baghbanzadeh, Amir; Shadbad, Mahdi Abdoli; Khosravi, Neda; Derakhshani, Afshin; Alemohammad, Hajar; Nour, Mina Afrashteh; Safarpour, Hossein; Silvestris, Nicola; Brunetti, Oronzo; Baradaran, Behzad

doi:10.1016/j.biopha.2021.112588

Cited by 23 publications

(18 citation statements)

References 130 publications

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“…TAMs are also critical regulators of tumors and are significantly associated with metastasis and drug resistance of cancer cells ( Guan et al, 2021 ; Ma et al, 2021 ). Recently, the advances in macrophage-based cancer immunotherapy have attracted more and more attention ( Baradaran et al, 2022 ). For example, Wang et al have constructed an engineering endogenous TAM-targeted biomimetic system to reprogram tumor immunosuppressive microenvironment and enhance chemo-immunotherapy ( Wang et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Reclassifying TNM stage I/II colorectal cancer into two subgroups with different overall survival, tumor microenvironment, and response to immune checkpoint blockade treatment

et al. 2022

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Background: The traditional TNM staging system is often insufficient to differentiate the survival discrepancies of colorectal cancer (CRC) patients at TNM stage I/II. Our study aimed to reclassify stage I/II CRC patients into several subgroups with different prognoses and explore their suitable therapeutic methods.Methods: Single-cell RNA (scRNA) sequencing data, bulk RNA sequencing data, and clinicopathological information of CRC patients were enrolled from the TCGA and GEO databases. The tumor microenvironment of CRC tissues was accessed by the ESTIMATE algorithm. The prognostic genes were identified by Cox regression analysis. GO and KEGG analyses were conducted in the DAVID database. GSEA analysis was performed for annotation of the correlated gene sets.Results: We successfully reclassified stage I/II CRC patients into two subgroups and discovered that patients in cluster-2 underwent worse overall survival than those in cluster-1. GSEA analysis showed that immune-associated gene sets were positively enriched in cluster-2. Besides, the differentially expressed genes (DEGs) between cluster-1 and cluster-2 patients also participated in immune-related biological processes and signaling pathways. Moreover, we found that more immune cells infiltrated the microenvironment of cluster-2 patients compared to that of cluster-1 patients, such as Tregs and tumor-associated macrophages. ScRNA sequencing analysis uncovered that most of the enriched immune-associated signaling in cluster-2 patients was mainly attributed to these upregulated immune cells whose infiltration levels were also high in CRC tissues rather than in normal tissues. In addition, we demonstrated that the expression of immune checkpoint genes was significantly higher in cluster-2 patients compared to cluster-1 patients. ScRNA sequencing analysis revealed that the infiltrated CD8+T cells in CRC were naïve T cells and can be activated into effector T cells after immune checkpoint blockade (ICB) treatment.Conclusion: TNM stage I/II CRC patients can be divided into two subgroups, which have different overall survival rates, tumor microenvironment, and response to ICB therapy.

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Section: Discussionmentioning

confidence: 99%

Reclassifying TNM stage I/II colorectal cancer into two subgroups with different overall survival, tumor microenvironment, and response to immune checkpoint blockade treatment

et al. 2022

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“…Macrophages can contribute to tumor angiogenesis by secreting basic FGF, macrophage migration inhibitory factor, platelet-activating factor, prostaglandin E2, osteopontin, adrenomedullin, VEGF-A, epidermal growth factor, placental growth factor, TGF-β, TNFα, IL-1β, IL-8, CCL2, CXCL8 and CXCL12 (57)(58)(59). A specific subpopulation of TAMs, which highly expresses immune checkpoint molecule B7 homolog 3 protein, also known as CD276, promoted angiogenesis and induced an immunosuppressive TME in a mouse model of TNBC (60).…”

Section: Blood Vessel Ecsmentioning

confidence: 99%

Interaction of tumor‑associated macrophages with stromal and immune components in solid tumors: Research progress (Review)

et al. 2023

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Tumor-associated macrophages (TAMs) are crucial cells of the tumor microenvironment (TME), which belong to the innate immune system and regulate primary tumor growth, immunosuppression, angiogenesis, extracellular matrix remodeling and metastasis. The review discusses current knowledge of essential cell-cell interactions of TAMs within the TME of solid tumors. It summarizes the mechanisms of stromal cell (including cancer-associated fibroblasts and endothelial cells)-mediated monocyte recruitment and regulation of differentiation, as well as pro-tumor and antitumor polarization of TAMs. Additionally, it focuses on the perivascular TAM subpopulations that regulate angiogenesis and lymphangiogenesis. It describes the possible mechanisms of reciprocal interactions of TAMs with other immune cells responsible for immunosuppression. Finally, it highlights the perspectives for novel therapeutic approaches to use combined cellular targets that include TAMs and other stromal and immune cells in the TME. The collected data demonstrated the importance of understanding cell-cell interactions in the TME to prevent distant metastasis and reduce the risk of tumor recurrence.

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“…Despite the fact that the importance of hypoxia in oncology is now widely recognized, understanding the many complex interactions of hypoxia and related TME stresses with cancer biology and therapy remains a work in progress [45]. Additionally, there are some excellent comprehensive reviews on the interplay between tumor cells and macrophages [46][47][48][49], but there are few reviews on the crosstalk mediated by hypoxia. Therefore, in order to identify new therapeutic targets, it is urgently necessary to have a thorough understanding of the intricate mechanisms underlying the hypoxia-mediated interaction between TAMs and tumor cells.…”

Section: Introductionmentioning

confidence: 99%

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

et al. 2022

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Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently. Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME), which have a large impact on tumor development and immunotherapy. TAMs massively accumulate within hypoxic tumor regions. TAMs and hypoxia represent a deadly combination because hypoxia has been suggested to induce a pro-tumorigenic macrophage phenotype. Hypoxia not only directly affects macrophage polarization, but it also has an indirect effect by altering the communication between tumor cells and macrophages. For example, hypoxia can influence the expression of chemokines and exosomes, both of which have profound impacts on the recipient cells. Recently, it has been demonstrated that the intricate interaction between cancer cells and TAMs in the hypoxic TME is relevant to poor prognosis and increased tumor malignancy. However, there are no comprehensive literature reviews on the molecular mechanisms underlying the hypoxia-mediated communication between tumor cells and TAMs. Therefore, this review has the aim to collect all recently available data on this topic and provide insights for developing novel therapeutic strategies for reducing the effects of hypoxia.

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The cross-talk between tumor-associated macrophages and tumor endothelium: Recent advances in macrophage-based cancer immunotherapy

Cited by 23 publications

References 130 publications

Reclassifying TNM stage I/II colorectal cancer into two subgroups with different overall survival, tumor microenvironment, and response to immune checkpoint blockade treatment

Reclassifying TNM stage I/II colorectal cancer into two subgroups with different overall survival, tumor microenvironment, and response to immune checkpoint blockade treatment

Interaction of tumor‑associated macrophages with stromal and immune components in solid tumors: Research progress (Review)

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

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