The Cross-talk, Genetic Alteration, Molecular Functions, and Cluster Relevance of the Major Types of Regulated Cell Death in Bladder Cancer

Abstract

OBJECTIVE To determine risk factors of abdominal distention after radical cystectomy and establish a nomogram for clinical risk assessment. MATERIALS AND METHODS We collected the clinical information of 139 patients who underwent radical cystectomy from January 2020 to August 2021. The chi-square test, hypergeometric tests, and univariate/multivariate logistic regression were utilized to explore the relationship between variables and abdominal distention after radical cystectomy. Then, a nomogram was used to predict the probability of abdominal distension for the patients who underwent radical cystectomy. Calibration and ROC curves were used to evaluate the accuracy of the model. RESULTS We found that 35 patients (25%) occurred in abdominal distention after radical cystectomy. Among these, 7 of them developed intestinal obstruction. Postoperative water fasting time and abdominal surgery history were independent risk factors for abdominal distension after surgery. Finally, we constructed a risk model to predict the probability of abdominal distension after surgery. This model showed good fitting and calibration and excellent diagnostic performance (AUC = 0.804). CONCLUSION Postoperative water fasting time and abdominal surgery history were independent risk factors for abdominal distension after surgery. There was no significant difference in the incidence of postoperative abdominal distention between robot-assisted cystectomy and laparoscopic cystectomy.