The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade

Abstract

The occurrence and progression of tumors are inseparable from glucose metabolism. With the development of tumors, the volume increases gradually and the nutritional supply of tumors cannot be fully guaranteed. The tumor microenvironment changes and glucose deficiency becomes the common stress environment of tumors. Here, we discuss the mutual influences between glucose deprivation and other features of the tumor microenvironment, such as hypoxia, immune escape, low pH, and oxidative stress. In the face of a series of stress responses brought by glucose deficiency, different types of tumors have different coping mechanisms. We summarize the tumor studies on glucose deficiency in the last decade and review the genes and pathways that determine the fate of tumors under harsh conditions. It turns out that most of these genes help tumor cells survive in glucose-deprivation conditions. The development of related inhibitors may bring new opportunities for the treatment of tumors.

Metabolomic profiling of upper GI malignancies in blood and tissue: a systematic review and meta-analysis

“…The accumulated lactic acid provides an acidic microenvironment that exacerbates the decomposition of the extracellular matrix by proteolytic activity (Bartman 2023 ; Lyssiotis and Cantley 2014 ). Several metabolites involved in cellular respiration, including lactic acid, glucose, citrate, and fumaric acid, have been frequently reported, but these results are inconsistent across studies (Cui et al 2023 ; Bose et al 2021 ). Moreover, opposite associations of some metabolites with UGI cancers are documented by different research groups (Matsumoto et al 2023 ; Li et al 2022 ; Wang et al 2020 ; Wang et al 2017 ; Hur et al 2014 ; Ikeda et al 2012 ).…”

Research advances in huntingtin-associated protein 1 and its application prospects in diseases

“…Furthermore, as a desirable outcome of targeted glucose metabolism for anticancer therapies (Cui et al, 2023), glucose deprivation-induced cell death is more pronounced in gastric cancer cells that overexpress HAP1 (Qu et al, 2023). In HAP1overexpressing gastric cancer cells, glucose deprivation leads to a significant decrease in ATP production and a significant increase in ROS production and triggers oxidative stress, which ultimately results in cell death (Qu et al, 2023).…”