2023
DOI: 10.3390/ijms241210322
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The Crosstalk between Gut Microbiota and Nervous System: A Bidirectional Interaction between Microorganisms and Metabolome

Abstract: Several studies have shown that the gut microbiota influences behavior and, in turn, changes in the immune system associated with symptoms of depression or anxiety disorder may be mirrored by corresponding changes in the gut microbiota. Although the composition/function of the intestinal microbiota appears to affect the central nervous system (CNS) activities through multiple mechanisms, accurate epidemiological evidence that clearly explains the connection between the CNS pathology and the intestinal dysbiosi… Show more

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Cited by 37 publications
(13 citation statements)
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“…[124] The gut brain axis constitutes a complex bidirectional communication system involving the ENS, the autonomic, and the CNS. [125] The ENS, often referred to as the "second brain," plays a crucial role in the interaction between the gut microbial community and the CNS within the gastrointestinal tract. Unger and colleagues postulated that microbial populations capable of producing SCFAs in the intestines are implicated in the formation of Lewy bodies in the ENS, and alterations in the ENS are regulated by SCFAs.…”
Section: Scfas and The Gut Brain Axismentioning
confidence: 99%
“…[124] The gut brain axis constitutes a complex bidirectional communication system involving the ENS, the autonomic, and the CNS. [125] The ENS, often referred to as the "second brain," plays a crucial role in the interaction between the gut microbial community and the CNS within the gastrointestinal tract. Unger and colleagues postulated that microbial populations capable of producing SCFAs in the intestines are implicated in the formation of Lewy bodies in the ENS, and alterations in the ENS are regulated by SCFAs.…”
Section: Scfas and The Gut Brain Axismentioning
confidence: 99%
“…Cortisol exerts its influence within the central nervous system (CNS) through both hormonal and neural communication pathways. These interacting pathways collectively affect the activities of various cell types within the gut, including intestinal effector cells, smooth muscle cells, epithelial cells, enterochromaffin cells, interstitial cells of Cajal, enteric neurons, and immune cells [ 25 ]. Consequently, conditions of stress lead to alterations in the gut microbiome, immune function, mucus production, intestinal motility, and permeability [ 26 ].…”
Section: Brain and Intestinal Microbiotic Interaction: A Molecular Pe...mentioning
confidence: 99%
“…Furthermore, distinct microbial compositions have been identified in these patients compared to healthy individuals. Notably, individuals with depressive disorder exhibit elevated levels of Actinomycetota , Pseudomonadota , and Bacteroidota phyla , alongside diminished populations of the Bacillota and Lactobacillaceae phyla [ 25 ]. Chen et al’s investigation into GM dysbiosis in women with MDD revealed significant enrichment of Bacteroidetes , Proteobacteria , and Fusobacteria phyla in patients, whereas higher levels of Firmicutes and Actinobacteria phyla were observed in healthy controls [ 55 ].…”
Section: Brain and Intestinal Microbiotic Interaction: A Molecular Pe...mentioning
confidence: 99%
“…Numerous methods exist for the microbiota in the gut, which is home to innumerable microbial species, to influence brain function and behavior, as revealed by newly emerging research on the gut‐brain axis. The gut's synthesis of neurotransmitters and neuromodulators is one important route (Montagnani et al, 2023). It has been shown that some gut bacteria are adept at producing chemicals that are essential for controlling mood and emotion, such as dopamine, gamma‐aminobutyric acid (GABA), and serotonin (Zhang, Sun, et al, 2023).…”
Section: Introductionmentioning
confidence: 99%