The Crucial Role of Inflammation and the Immune System in Colorectal Cancer Carcinogenesis: A Comprehensive Perspective

Burgos-Molina, Antonio Manuel; Téllez Santana, Teresa; Redondo, Maximino; Bravo Romero, María José

doi:10.3390/ijms25116188

Cited by 4 publications

(1 citation statement)

References 135 publications

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“…Myeloperoxidase (MPO) is an enzyme produced by neutrophils during in ammation, serving as a marker for oxidative stress and neutrophil in ltration [20,21]. The expression of Pro-in ammatory cytokines, such as TNF-α, IL-6, IL-1β, and arginase play pivotal roles in the in ammatory cascade of UC [9,22]. As shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Humic Acid Attenuates DSS-Induced Colitis, Increases MUC-2 Expression, and Restores Colonic Histoarchitectural Damage in Adult Male Wistar Rats

Omolaso,

Adeniran,

Ogunmiluyi

et al. 2024

Preprint

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This study investigates the role of humic acid (HA) in attenuating Dextran sulfate sodium (DSS)-induced UC in male Wistar rats. Twenty male Wistar rats were randomly assigned to groups (n = 5). Group 1 served as controls; Group 2 received 5% DSS alone; Group 3 received 5% DSS followed by humic acid (30 mg/kg); and Group 4 received 5% DSS followed by sulfasalazine (200 mg/kg). DSS was administered orally to induce colitis in Groups 2, 3, and 4. Colitis was induced for five days and drug treatment done for another 5 days Disease activity index was assessed on days 1, 3, 5, and 10. Animals were euthanized by cervical dislocation, colon specimens harvested for macroscopic assessment, histological and biochemical assays. Data were analyzed using one way ANOVA (p < 0.05). Results show humic acid treatment significantly attenuated DSS-induced colitis by reducing inflammation markers (TNF-α, interleukin-6, interleukin-1β, and arginase), lipid peroxidation (MPO) and restoring colonic histological integrity. Significant improvements were observed in colonic tissue nitrite levels and Muc-2 expression. Conclusively, HA shows promise as an alternative therapeutic for UC, offering antioxidant, anti-inflammatory, and mucosal barrier-protective effects.

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Section: Discussionmentioning

confidence: 99%

Humic Acid Attenuates DSS-Induced Colitis, Increases MUC-2 Expression, and Restores Colonic Histoarchitectural Damage in Adult Male Wistar Rats

Omolaso,

Adeniran,

Ogunmiluyi

et al. 2024

Preprint

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Vagus nerve stimulation: Novel concept for the treatment of glioblastoma and solid cancers by cytokine (interleukin-6) reduction, attenuating the SASP, enhancing tumor immunity

Brem

2024

Brain, Behavior, & Immunity - Health

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Potential Utility of A Proliferation-Inducing Ligand (APRIL) in Colorectal Cancer

Zajkowska,

Orywal,

Gryko

2024

IJMS

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APRIL (A proliferation-inducing ligand) is a member of the tumor necrosis factor superfamily that is overexpressed in a variety of malignant tumors, including colorectal cancer (CRC). Its key physiological roles include inducing the immunoglobulin switch and ensuring plasmocyte survival. In terms of pathological roles, APRIL antagonism has been identified as a key target in autoimmune diseases and immunoglobulin disorders. As previously demonstrated, several inflammatory processes occur at the site of neoplastic initial stages, and their local symptoms are difficult to detect, particularly in the early stages. That is why we chose to study the current literature on APRIL’s role in the development of colorectal cancer. The main objective of our research was to investigate the role of APRIL in cancer initiation and its usefulness in the detection and therapy of CRC. Interestingly, the findings conducted so far show that the selected protein has a significant potential as a CRC biomarker and treatment target. Importantly, based on its concentration, it is possible to identify CRC patients, but whether the lesion has a benign or malignant nature, indicating the possibility of rapid detection of an ongoing disease process.

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The Crucial Role of Inflammation and the Immune System in Colorectal Cancer Carcinogenesis: A Comprehensive Perspective

Cited by 4 publications

References 135 publications

Humic Acid Attenuates DSS-Induced Colitis, Increases MUC-2 Expression, and Restores Colonic Histoarchitectural Damage in Adult Male Wistar Rats

Humic Acid Attenuates DSS-Induced Colitis, Increases MUC-2 Expression, and Restores Colonic Histoarchitectural Damage in Adult Male Wistar Rats

Vagus nerve stimulation: Novel concept for the treatment of glioblastoma and solid cancers by cytokine (interleukin-6) reduction, attenuating the SASP, enhancing tumor immunity

Potential Utility of A Proliferation-Inducing Ligand (APRIL) in Colorectal Cancer

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