2024
DOI: 10.21608/erurj.2024.228118.1067
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The crucial role of long non-coding RNAs in the pathogenesis, therapeutic response, and clinical implications of esophageal cancer

Ahmed El-Husseiny,
Nada Ali,
Morkoss Fakhry

Abstract: Esophageal cancer (EC) is the 2nd fatal gastrointestinal tract malignancy and the sixth most predominant driver of cancer-associated mortality worldwide. Interestingly, long non-coding RNAs (lncRNAs) have a sequence of more than 200 base pairs and are regarded as one of the epigenetic elements. LncRNAs have been demonstrated to influence EC features comprising initiation, development, angiogenesis, invasion, and metastasis. Notably, lncRNAs could modulate the expression of several genes and chromatin architect… Show more

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