The crucial role of silver(i)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

Abstract

This review discusses the important role of silver(i) salts as additives in transition-metal catalyzed C–H activation, and depicts the discussion about the current shift towards Ag-free procedures, as plausible and sustainable alternatives.

Crafting 1,4-diaryl spirobifluorene hosts in OLEDs via interannular C–H arylation: synergistic effects of molecular linearity and orthogonality

“…Given the crucial role of silver salts in arylating reactions with iodobenzene substrates, we conducted a screening of various silver salts. 34 The results indicated that silver trifluoroacetate (AgTFA) exhibited the best reaction efficiency. The replacement of Ag 2 CO 3 with AgTFA significantly improved the reaction yield, reaching 72% ( Table 1 , entry 8).…”

Backbone-enabled modification of peptides with benzoquinone via palladium-catalyzed δ-C(sp2)–H functionalization

“…Meanwhile, the reduced Pd(0) species was oxidized to the Pd( ii ) catalyst with the assistance of a stoichiometric amount of silver, which was subsequently used in the next catalytic cycle. 20…”

Synthesis of gem-difluorinated pentacyclic indenopyrazolopyrazolones via Rh(iii)-catalyzed cascade C–H functionalization/[3 + 2] dipolar cycloaddition

“…1 As a consequence, various strategies have been developed for rapid access to intriguing fused compounds, among which transition metal (TM)-catalysed C–H functionalization represents a straightforward protocol due to its high efficiency and remarkable atom-/step-economy. 2 To date, a series of versatile directing groups (DGs) and coupling partners (CPs) have been discovered for addressing the synthesis of complex polycyclic ring-fused structures via a TM-catalysed C–H coupling/cyclization cascade involving the formation of multiple new bonds in a simple one-pot operation, illustrating that the combination of TM-catalysed C–H functionalization and the cascade strategy should be a viable tool for the efficient construction of fused heterocycles. 3…”