The crucial role of the public health sciences in the postgenomic era

Omenn, Gilbert S.

doi:10.1097/00125817-200211001-00005

Cited by 9 publications

(2 citation statements)

References 27 publications

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“…Elsewhere I predicted that we were entering a "golden age" for the public health sciences as epidemiology, biostatistics, environmental health, health behavior, and health services research would need to be brought to bear on the study of gene-environment interactions, or "eco-genetics" (16). This prediction is coming true with genome-wide association studies (GWASs) of numerous diseases, databases for pharmacogenomics, many kinds of host-pathogen discoveries, recognition of the relevance of evolutionary biology and psychology in medicine and public health (13,14,18), and progress toward predictive, personalized, and preventive health care (1).…”

Section: Introductionmentioning

confidence: 99%

Overview of the Symposium on Public Health Significance of Genomics and Eco-Genetics

Omenn

2010

Annu. Rev. Public Health

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Genomic and genetic information is rapidly becoming a major element in public health research and emerging public health practice. This symposium reviews the methods, findings, and significance of genomewide association studies from epidemiological and statistical points of view. We examine infectious and inflammatory components of geneenvironment interaction in the respiratory system. We note the need for nutrient and dietary data and many other kinds of environmental exposure data in population-based genomic studies. Then we explore the sufficiency of a well-informed family history for public health and family counseling purposes. Finally, in an era of direct-to-consumer genomic test promotion, we review the evidence on the critical question, will genetic risk profiles motivate individuals and families to choose more healthful behaviors? This symposium builds on the foundation of the symposium on

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Section: Introductionmentioning

confidence: 99%

Overview of the Symposium on Public Health Significance of Genomics and Eco-Genetics

Omenn

2010

Annu. Rev. Public Health

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“…It is clearly more desirable to identify early changes in biologic processes that can serve as predictive markers of exposure, of early effect, or of susceptibility [Committee on Biological Markers of the National Research Council (NRC) 1987]. These components of the proposed continuum between exposure and disease have been described in a number of reports (Lioy 1990; Maier et al 2004; NRC 1987; Omenn 2002; Perera and Weinstein 1982; Pesch et al 2004; Schulte 1989; Waters and Fostel 2004). It is important to remember that the distinctions between exposure and response in this continuum are arbitrary.…”

Section: Exposure Assessment Methodsmentioning

confidence: 99%

Personalized Exposure Assessment: Promising Approaches for Human Environmental Health Research

Weis

Balshaw

Barr

et al. 2005

Environ Health Perspect

119

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New technologies and methods for assessing human exposure to chemicals, dietary and lifestyle factors, infectious agents, and other stressors provide an opportunity to extend the range of human health investigations and advance our understanding of the relationship between environmental exposure and disease. An ad hoc Committee on Environmental Exposure Technology Development was convened to identify new technologies and methods for deriving personalized exposure measurements for application to environmental health studies. The committee identified a “toolbox” of methods for measuring external (environmental) and internal (biologic) exposure and assessing human behaviors that influence the likelihood of exposure to environmental agents. The methods use environmental sensors, geographic information systems, biologic sensors, toxicogenomics, and body burden (biologic) measurements. We discuss each of the methods in relation to current use in human health research; specific gaps in the development, validation, and application of the methods are highlighted. We also present a conceptual framework for moving these technologies into use and acceptance by the scientific community. The framework focuses on understanding complex human diseases using an integrated approach to exposure assessment to define particular exposure–disease relationships and the interaction of genetic and environmental factors in disease occurrence. Improved methods for exposure assessment will result in better means of monitoring and targeting intervention and prevention programs.

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The Genomic Era: What MUST Public Health Do?

2003

AMA Journal of Ethics

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In a recent paper proposing "a vision for the future of genomics," representatives of the US National Human Genome Research Institute (NHGRI) suggested that, "with the completion of a high-quality, comprehensive sequence of the human genome…the genomic era is now a reality" [1]. The underlying assumption, that in this new era medical innovations born of genomics will lead to significant improvements in human health, is a safe one. Though unlikely to give rise to a panacea for genetically transmitted disease and dysfunction, our ever clearer understanding of the genetic underpinnings of disease will most certainly have a substantial impact on health care. As the NHGRI group went on to concede, however, the widespread application of genomics to health is some years away.

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The crucial role of the public health sciences in the postgenomic era

Cited by 9 publications

References 27 publications

Overview of the Symposium on Public Health Significance of Genomics and Eco-Genetics

Overview of the Symposium on Public Health Significance of Genomics and Eco-Genetics

Personalized Exposure Assessment: Promising Approaches for Human Environmental Health Research

The Genomic Era: What MUST Public Health Do?

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