The Crucial Roles and Research Advances of cGAS-STING Pathway in Cutaneous Disorders

Huang, Cong; Li, Wenting; Ren, Xuanyao; Tang, Mindan; Zhang, Kaoyuan; Fan, Zusen; Dou, Xia; Yu, Bo

doi:10.1007/s10753-023-01812-7

Cited by 3 publications

(1 citation statement)

References 131 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dysfunction of the cGAS–STING signaling pathway may also play a role in various cutaneous diseases. 307 It has been reported that expression levels of STING and its downstream factors are significantly higher in diseased skin samples from psoriasis patients (compared with levels in skin samples from healthy people), These results reveal the potential involvement of STING dysregulation in the pathogenesis of psoriasis. The STING agonist 5,6‐dimethylxanthone‐4‐acetic acid (DMXAA) is known to aggravate psoriasis symptoms and skin inflammation, while the STING antagonist H‐151 exhibits anti‐inflammatory activity in imiquimod (IMQ)‐induced psoriasis mice, 308 , 309 it can be concluded from these results that STING activation promotes the occurrence of psoriasis inflammation.…”

Section: Activation and Inhibition Of Cgas–sting Under The Pathologic...mentioning

confidence: 73%

cGAS–STING, an important signaling pathway in diseases and their therapy

Li,

Wu,

et al. 2024

MedComm

View full text Add to dashboard Cite

Since cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great progress has been made to elucidate the origin, function, and regulating mechanism of cGAS–STING signaling pathway in the past decade. Meanwhile, the triggering and transduction mechanisms have been continuously illuminated. cGAS–STING plays a key role in human diseases, particularly DNA‐triggered inflammatory diseases, making it a potentially effective therapeutic target for inflammation‐related diseases. Here, we aim to summarize the ancient origin of the cGAS–STING defense mechanism, as well as the triggers, transduction, and regulating mechanisms of the cGAS–STING. We will also focus on the important roles of cGAS–STING signal under pathological conditions, such as infections, cancers, autoimmune diseases, neurological diseases, and visceral inflammations, and review the progress in drug development targeting cGAS–STING signaling pathway. The main directions and potential obstacles in the regulating mechanism research and therapeutic drug development of the cGAS–STING signaling pathway for inflammatory diseases and cancers will be discussed. These research advancements expand our understanding of cGAS–STING, provide a theoretical basis for further exploration of the roles of cGAS–STING in diseases, and open up new strategies for targeting cGAS–STING as a promising therapeutic intervention in multiple diseases.

show abstract

Section: Activation and Inhibition Of Cgas–sting Under The Pathologic...mentioning

confidence: 73%

cGAS–STING, an important signaling pathway in diseases and their therapy

Li,

Wu,

et al. 2024

MedComm

View full text Add to dashboard Cite

show abstract

Ozone exposure affects corneal epithelial fate by promoting mtDNA leakage and cGAS/STING activation

Fan,

Dong,

Fang

et al. 2024

Journal of Hazardous Materials

View full text Add to dashboard Cite

cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics

Mahin,

Xu,

et al. 2024

Cell Commun Signal

View full text Add to dashboard Cite

Melanoma, recognized as the most aggressive type of skin cancer, has experienced a notable increase in cases, especially within populations with fair skin. This highly aggressive cancer is largely driven by UV radiation exposure, resulting in the uncontrolled growth and malignant transformation of melanocytes. The cGAS-STING pathway, an immune signaling mechanism responsible for detecting double-stranded DNA in the cytoplasm, is essential for mediating the immune response against melanoma. This pathway serves a dual purpose: it enhances antitumor immunity by activating immune cells, but it can also promote tumor growth when chronically activated by creating an immunosuppressive environment. This review comprehensively examines the multifaceted implication of the cGAS-STING pathway in melanoma pathogenesis and treatment. We explore its molecular mechanisms, including epigenetic regulation, interaction with signaling pathways such as AR signaling, and modulation by various cellular effectors like TG2 and activin-A. The therapeutic potential of modulating the cGAS-STING pathway is highlighted, with promising results from STING agonists, combination therapies with immune checkpoint inhibitors, and novel drug delivery systems, including nanoparticles and synthetic drugs. Our findings underscore the importance of the cGAS-STING pathway in melanoma, presenting it as a critical target for enhancing anti-tumor immunity. By leveraging this pathway, future therapeutic strategies can potentially convert ‘cold’ tumors into ‘hot’ tumors, making them more susceptible to immune responses.

show abstract

The Crucial Roles and Research Advances of cGAS-STING Pathway in Cutaneous Disorders

Cited by 3 publications

References 131 publications

cGAS–STING, an important signaling pathway in diseases and their therapy

cGAS–STING, an important signaling pathway in diseases and their therapy

Ozone exposure affects corneal epithelial fate by promoting mtDNA leakage and cGAS/STING activation

cGAS/STING in skin melanoma: from molecular mechanisms to therapeutics

Contact Info

Product

Resources

About