The crystal structure of the steroid 6β,7β-methylene-17β-hydroxyandrost-4-en-3-one 17-acetate

Braun, P. B.; Hornstra, J.; Leenhouts, J. I.

doi:10.1107/s0567740870002388

Cited by 8 publications

(2 citation statements)

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“…Final fractional atomic co-ordinates and anisotropic thermal parameters ( x lo4) *, with estimated standard deviations in parentheses -181 (23) -1 200(2) 2 16 ( 25) 6 1 7 ( 20) 135( 18) 604( 19) 880( 17) 820( 18) 420( 16)…”

Section: Tablementioning

confidence: 99%

“…The configuration of the molecule is illustrated l1 in The steroid skeleton consists of the thiiran Figure 1. 24) 1.530 ( 23) 1.526 (25) 1.546 (23) 1.500 (23) 1. 5 35 (22) 1.5 1 3 (22) 1.531 (28) 1.557(25) 1.538 (30) 1.549( 28) 1.3 8 7 (23) 1.3 67 (24) 1.543 ( 23) 1.41 9 (26) 1.2 1 2 (28) 1.473(28) 1.3 50 ( 24 6)-H( 6) that of the previously reported 2a,3a-epithio-5a-androstan-17p-yl 9-bromobenzoate (I).…”

Section: Tablementioning

confidence: 99%

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Crystal structure of 2α,3α-epithio-5α-androst-6-en-17β-yl p-bromobenzoate

UTSUMI-ODA¹,

Koyama²

1975

J. Chem. Soc., Perkin Trans. 2

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The crystal structure of the title compound (11) has been determined by three-dimensional X-ray analysis from diffractometer data. Crystals are orthorhombic, a = 18.796 * 0.003, b = 9.657 f 0.002, c = 12.773 f 0.003 A.The structure was solved by the program SEARCHER, for automatic heavy-atom analysis, and refined by full-matrix least-squares calculations to a final R of 0.083 for 1 273 independently observed reflections. Hydrogen atoms were located from a difference-Fourier synthesis. The absolute configuration was determined by the anomalous dispersion method. All the ring junctions are trans,trans. Rings A and B of the steroid skeleton have a half-chair, and ring c a chair conformation. The cyclopentane ring D has a distorted C(13) envelope conformation. ku, Osaka, 553 Japan AS thiosteroid derivatives have many interesting physiological and biological properties, Takeda l r 2 and his coworkers have studied the structure and conformational properties of these compounds on the basis of chemical evidence. In conjunction with a chemical study of thiosteroid derivatives, we have recently determined the structure of 2~,3a-epithio-5a-androstan-l7@-yl 9bromobenzoate (I), and found that introduction of the

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Section: Tablementioning

confidence: 99%

Section: Tablementioning

confidence: 99%