The crystal structure of uridine

Abstract

Crystals of uridine, C9HI2N206, are monoclinic, space group P21 with a=4.981 (4), b= 14.649 (8), c= 13"964 (8)A, fl= 95"45 (8) ° and Z= 4, The structure was solved by the direct method and refined by least-squares calculations, using Ni-filtered Cu Ke diffractometer data. The final R index was 0.033 for 2232 reflections, and the standard deviations in the atomic positions are about 0.003 A. The two independent molecules have very similar conformations; the conformation about the glycosidic bond is anti, the sugar ring is puckered with C(Y) endo, and the conformation about C(4")-C(5') is gauchegauche.

Structure of 5-[(1S,2S)-2-chlorocyclopropyl]-1-(2-deoxy-β-D-ribofuranosyl)uracil

“…Bond lengths and bond angles are similar to those reported for deoxyuridine (Green, Rosenstein, Shiono, Abraham, Trus & Marsh, 1975) and other related compounds. When the 1-(2-deoxy-Dribofuranosyl)-5-[(1 S)-2,2-dibromocyclopropyl]uracil structure (Moore, Santarsiero, Lin, James, Tandon, Wiebe & Knauss, 1989) (7) -0.2186 (2 …”

Elementary binding patterns in protein–nucleic acid interactions. Structure of 1-(2-carbamoylethyl)uracil, C7H9N3O3

“…The pyrimidine ring is planar within +0.020 A. The bond distances and angles of the uracil moiety are in good agreement with those of 1-(2-carboxyethyl)uracil (Fujita, Takenaka & Sasada, 1982) and uridine (Green, Rosenstein, Shiono, Abraham, Trus & Marsh, 1975). The dimensions of the carbamoyl group are close to those of asparagine * Lists of structure factors, anisotropic thermal parameters, H-atom coordinates, bond distances and angles involving H atoms, least-squares planes for the pyrimidine ring and the carbamoyl group and hydrogen-bond geometry have been deposited with the British Library Lending Division as Supplementary Publication No.…”

Amino acid substitutions in the CytR repressor which alter its capacity to regulate gene expression

“…The formation of a bond between the Asp-281 carboxyl group and the cytidine 4-amino group could serve as the trigger for induction of Cy-tR-controlled gene expression. This specific interaction between repressor and inducer could explain why uridine, which has the same conformation as cytidine (14,28,29), is not an inducer of CytR-regulated gene expression in E. coli. The question of whether CID mutants are defective in cytidine binding or in their response to bound cytidine is currently being examined.…”