The Cultivable Bacterial Microbiota Associated to the Medicinal Plant Origanum vulgare L.: From Antibiotic Resistance to Growth-Inhibitory Properties

Castronovo, Lara Mitia; Calonico, Carmela; Ascrizzi, Roberta; Duca, Sara Del; Delfino, Vania; Chioccioli, Sofia; Vassallo, Alberto; Strozza, Iolanda; Leo, Marinella De; Biffi, Sauro; Bacci, Giovanni; Bogani, Patrizia; Maggini, Valentina; Mengoni, Alessio; Pistelli, Luisa; Nostro, Antonella Lo; Firenzuoli, Fabio; Fani, Renato

doi:10.3389/fmicb.2020.00862

Cited by 24 publications

(45 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They were abundant members of the leaf communities of both MPs, but differences on the genus level were monitored, indicating that each plant selects for its specific bacterial community. As our and data from other studies show, bacteria can also be prominent members of the flower communities, in particular Enterobacteriaceae (Shade et al, 2013;Aleklett et al, 2014;Junker and Keller, 2015;Wei and Ashman, 2018;Castronovo et al, 2020). In fact, Enterobacteriaceae appear to be specifically associated to the style and stamen of the flower as reported for the tree M. polymorpha (Junker and Keller, 2015).…”

Section: Microbial Taxa Of the Plant And Soil Communitiessupporting

confidence: 77%

“…Other comparative studies have shown that the microbiome of different plants is distinct, reflecting the specific feature of the given plant and its environment ( Copeland et al, 2015 ; Lumactud and Fulthorpe, 2018 ; Massoni et al, 2020 ). The various microbial taxa include commensals, potential pathogens but also probiotic and host growth-promoting members interacting with other microbes and the host plant in various mutualistic and antagonistic and still little understood ways ( Hardoim et al, 2015 ; Berg et al, 2016 ; Brader et al, 2017 ; Castronovo et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Further, implications of the microbiome on agricultural management ( Toju et al, 2018 ; Jones et al, 2019 ; Pacifico et al, 2019 ; Lyu et al, 2020 ), crop quality and postharvest processes ( Rillig et al, 2018 ) have been addressed. Several studies investigated the microbiome of medicinal plants (MPs), e.g., Origanum vulgare ( Pontonio et al, 2018 ; Castronovo et al, 2020 ), Matricaria chamomilla, and Calendula officinalis ( Köberl et al, 2019 ) as well as Salvia miltiorrhiza ( Chen et al, 2018 ; Huang et al, 2018 ). MPs are characterized by a high variety of unique secondary metabolites and many endophytes producing pharmacologically active substances ( Köberl et al, 2013 ; Golinska et al, 2015 ; Ivanova et al, 2016 ; Rahman et al, 2017 ; Caruso et al, 2020 ; Gupta et al, 2020 ; Teimoori-Boghsani et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Microbiome of the Medicinal Plants Achillea millefolium L. and Hamamelis virginiana L.

et al. 2021

View full text Add to dashboard Cite

In the recent past many studies investigated the microbiome of plants including several medicinal plants (MP). Microbial communities of the associated soil, rhizosphere and the above-ground organs were included, but there is still limited information on their seasonal development, and in particular simultaneous investigations of different plant organs are lacking. Many studies predominantly addressed either the prokaryotic or fungal microbiome. A distinction of epi- and endophytic communities of above-ground plant organs has rarely been made. Therefore, we conducted a comprehensive investigation of the bacterial and fungal microbiome of the MP Achillea millefolium and studied the epi- and endophytic microbial communities of leaves, flower buds and flowers between spring and summer together with the microbiome of the associated soil at one location. Further, we assessed the core microbiome of Achillea from four different locations at distances up to 250 km in southern Germany and Switzerland. In addition, the bacterial and fungal epi- and endophytic leaf microbiome of the arborescent shrub Hamamelis virginiana and the associated soil was investigated at one location. The results show a generally decreasing diversity of both microbial communities from soil to flower of Achillea. The diversity of the bacterial and fungal endophytic leaf communities of Achillea increased from April to July, whereas that of the epiphytic leaf communities decreased. In contrast, the diversity of the fungal communities of both leaf compartments and that of epiphytic bacteria of Hamamelis increased over time indicating plant-specific differences in the temporal development of microbial communities. Both MPs exhibited distinct microbial communities with plant-specific but also common taxa. The core taxa of Achillea constituted a lower fraction of the total number of taxa than of the total abundance of taxa. The results of our study provide a basis to link interactions of the microbiome with their host plant in relation to the production of bioactive compounds.

show abstract

Section: Microbial Taxa Of the Plant And Soil Communitiessupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Microbiome of the Medicinal Plants Achillea millefolium L. and Hamamelis virginiana L.

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Lastly, but not least, endophytes could be selected in relation to their antimicrobial resistance phenotype as a response to antimicrobial molecules produced by microorganisms in the same ecological niche [ 31 ]. This hypothesis has been suggested in the case of the three MPs, E. purpurea and E. angustifolia [ 13 , 31 , 36 ], and O. vulgare [ 37 ]. Here, different plant compartments were characterized by different antimicrobial resistance patterns and antagonistic interactions.…”

Section: Introduction To Medicinal Plantsmentioning

confidence: 95%

“…Human health is seriously threatened by the constant emergence of multi-drug resistant (MDR) microorganisms and the drying up of the pipelines of new antibiotic discovery. Many studies have demonstrated that bacterial endophytes of MPs could be promising sources of antimicrobial molecules [ 37 , 38 , 39 , 68 , 99 , 100 ]. On the other hand, since 1985, very few new classes of antibiotics have been discovered, highlighting the need for an alternative strategy to isolate effective antibiotics from endophytes [ 69 ].…”

Section: Biotechnological and Therapeutical Applicationsmentioning

confidence: 99%

Medicinal Plants and Their Bacterial Microbiota: A Review on Antimicrobial Compounds Production for Plant and Human Health

Castronovo

Vassallo²,

Mengoni³

et al. 2021

Pathogens

Self Cite

View full text Add to dashboard Cite

Medicinal plants (MPs) have been used since antiquity in traditional and popular medicine, and they represent a very important source of bioactive molecules, including antibiotic, antiviral, and antifungal molecules. Such compounds are often of plant origin, but in some cases, an origin or a modification from plant microbiota has been shown. Actually, the research continues to report the production of bioactive molecules by plants, but the role of plant–endophytic interaction is emerging. Classic examples are mainly concerned with fungal endophytes; however, it has been recently shown that bacterial endophytes can also play an important role in influencing the plant metabolism related to the synthesis of bioactive compounds. In spite of this, a deep investigation on the power of MP bacterial endophytes is lacking. Here, an overview of the studies on MP bacterial microbiota and its role in the production of plant antimicrobial compounds contributing to prime host defense system and representing a huge resource for biotech and therapeutic applications is provided.

show abstract

Endophytes and their secondary metabolites against human pathogenic MDR microbes

Srivastava¹,

Raghuwanshi²

2023

Endophytic Association: What, Why and How

View full text Add to dashboard Cite

The Cultivable Bacterial Microbiota Associated to the Medicinal Plant Origanum vulgare L.: From Antibiotic Resistance to Growth-Inhibitory Properties

Cited by 24 publications

References 50 publications

The Microbiome of the Medicinal Plants Achillea millefolium L. and Hamamelis virginiana L.

The Microbiome of the Medicinal Plants Achillea millefolium L. and Hamamelis virginiana L.

Medicinal Plants and Their Bacterial Microbiota: A Review on Antimicrobial Compounds Production for Plant and Human Health

Endophytes and their secondary metabolites against human pathogenic MDR microbes

Contact Info

Product

Resources

About