The implementation of the quality assurance and accreditation processes in Higher Education Institutions (HEIs) are naturally dependent on human and non-human factors. This means that the human role in the whole process is quite essential. The workforce is the concerned side to implement, review the implementation, correct the mistakes, document procedures, and defend the quality systems being followed. The HEI internal stakeholders are major factors in deciding whether the institution can successfully go about its quality assurance activities or not. The review of the literature intensifies the necessity to expand upon the main elements to influence higher education quality assurance activities and accreditation. This chapter discusses in detail the major factors to influence quality assurance practices and HEIs' accreditation processes. They include the following: quality assurance awareness, investment priorities, capacity and capability, perception of stakeholders, the recruitment – roles of quality managers, and gaming the quality assurance and accreditation systems.