The curative effects of the traditional Chinese herbal medicine “Jinchuang ointment” on excisional wounds

Abstract

Background “Jinchuang ointment” is a traditional Chinese herbal medicine for external incised wounds. This herbal medicine has been successfully used to treat patients with diabetic foot ulcers and pressure sores in Taiwan for several decades. We previously examined its biological activities on cell-based in vitro assay platforms. Because some patients refused to use animal-derived ingredients ointment during our clinical practice, the efficacy of plant oil-based reconstituted “Jinchuang ointment” was also investigated. Methods A porcine excisional wound model was established and used to evaluate its efficacy in vivo in this study. Besides, an unusual clinical case is also present. Results As judged from the wound appearance of animal studies on day 14 and the results of blood flow flux at the wound sites on day 28, “Jinchuang ointment” accelerated wound closure significantly better than the control group. Conclusions The results from clinical treatment, histopathological evaluation, and the animal study showed that “Jinchung ointment” promotes wound healing significantly better than the control group. Also, sesame oil-reconstituted ointment can be a choice for patients who refuse to use lard-containing ointment.

Antimicrobial and Immunomodulatory Activity of Herb Extracts Used in Burn Wound Healing: “San Huang Powder”

“…e pigs were 4.5 months old (average weight: 18.0 kg) and had similar body shapes. Each animal was maintained as described previously [7].…”

“…After fixation, the tissues were trimmed, embedded, and divided into 5 mm thick sections and placed on glass slides (Immuno Coated slide, MUTO, Japan). ese paraffin-embedded sections were treated with hematoxylin and eosin (H & E), Masson-trichrome (MT) stains, and immunohistochemistry (IHC) stain, as reported previously [7].…”

“…e in vitro immunomodulatory activity of herbal materials was also investigated. Since pig skin structure and function have the closest resemblance to that of humans [6,7], we used an in vivo porcine burn model in healing burn wounds to examine the efficacy of two different "San Huang Powder" recipes. e results obtained in this study provide the scientific basis for its clinical use and insight for preparation of next generation "San Huang Powder" extract.…”

Role of Herbal Extracts of Catechu from Uncaria gambir in the Treatment of Chronic Diabetic Wounds

“…The traditional Chinese herbal medicine, “Jinchuang ointment,” has excellent efficacy in the treatment of chronic non-healing wounds in patients with diabetes [ 1 ]. Its efficacy was also examined and confirmed in a porcine excisional wound model [ 2 ]. This herbal medicine is also effective for ulcers in people with leprosy (Hansen’s disease) [ 3 ].…”

“…Our previous results indicated that the Jinchuang ointment-treated group had a much stronger blood flow flux in porcine excisional wound sites than the control group, as shown by laser Doppler imaging analysis [ 2 ]. First, we attributed these results to the angiogenic activity of dragon blood during wound healing.…”