THE CURCUMIN CONTENT OF TEMULAWAK(Curcuma xanthorriza Roxb.) RHIZOME AS AFFECTED BY N, K AND MICRONUTRIENTS B, Fe, Zn

Nihayati, Ellis; Wardiyati, Tatik; Retnowati, Rurini; Soemarno, Soemarno

doi:10.17503/agrivita-2013-35-3-p218-226

Cited by 8 publications

(10 citation statements)

References 3 publications

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“…In vitro work has suggested that the galangal component 1′-acetoxychavicol modulates a transient receptor potential (TRP) cation channel [ 25 ]. Javanese ginger contains curcumin [ 26 ] and zanthorrhizol, which is also a Cox-2 inhibitor [ 27 ]. Javanese ginger extract and zanthorrhizol have anti-inflammatory effects in vivo [ 28 ] and Javanese ginger extract displayed anti-nociceptive effects in mice [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Zingiberaceae extracts for pain: a systematic review and meta-analysis

Lakhan

Ford

Tepper

2015

Nutr J

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BackgroundMembers of the family Zingiberaceae including turmeric, ginger, Javanese ginger, and galangal have been used for centuries in traditional medicine. Preclinical studies of Zingiberaceae extracts have shown analgesic properties. This study aims to systematically review and meta-analyze whether extracts from Zingiberaceae are clinically effective hypoalgesic agents.MethodsLiterature was screened from electronic databases using the key words Zingiberaceae AND pain OR visual analogue score (VAS) to identify randomized trials. From this search, 18 studies were identified, and of these, 8 randomized, double-blinded, placebo-controlled trials were found that measured pain by VAS for inclusion in the meta-analysis.ResultsFindings indicated significant efficacy of Zingiberaceae extracts in reducing subjective chronic pain (SMD − 0.67; 95 % CI − 1.13 to − 0.21; P = 0.004). A linear dose-effect relationship was apparent between studies (R2 = 0.71). All studies included in the systematic review reported a good safety profile for extracts, without the renal risks associated with non-steroidal anti-inflammatory drugs, and with similar effectiveness.ConclusionOur findings indicated that Zingiberaceae extracts are clinically effective hypoalgesic agents and the available data show a better safety profile than non-steroidal anti-inflammatory drugs. However, both non-steroidal anti-inflammatory drugs and Zingiberaceae have been associated with a heightened bleeding risk, and there have been no comparator trials of this risk. Further clinical studies are recommended to identify the most effective type of Zingiberaceae extract and rigorously compare safety, including bleeding risk.

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Section: Introductionmentioning

confidence: 99%

Zingiberaceae extracts for pain: a systematic review and meta-analysis

Lakhan

Ford

Tepper

2015

Nutr J

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“…The use of Curcuma xanthorrhiza Roxb. as the source of curcumin for medicine has been increasing due to the increasing awareness for nature-based medicine and the rising price of chemicals (Nihayati et al, 2013). In the world, curcumin demand was fulfilled from turmeric extract which is coming from India.…”

Section: A B S T R a Kmentioning

confidence: 99%

Synthesis of Curcumin Nanoparticle from Curcuma xanthorrhiza Roxb Extract by Solvent-Antisolvent Precipitation Method

2019

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A B S T R A C TCurcumin is an active compound found in temulawak (Curcuma xanthorrhiza Roxb.) extract which is widely used for biomedical application. However, the utilization of curcumin is still limited due to its properties i.e. hydrophobicity, poor stability, and low water solubility. Modification of curcumin molecule and process optimization during the extraction and purification process is needed to minimize the aforementioned limitations. One of the approaches is producing curcumin in nano size. This present research aims to optimize the synthesis of curcumin nanoparticle from Curcuma xanthorrhiza Roxb. extract using solvent-antisolvent precipitation method. Curcumin colour stability was also enhanced by controlling the pH during raw materials preparation. The obtained curcumin nanoparticle was then characterized using particle size analysis (PSA). Result showed that Curcuma xanthorrhiza Roxb. extract colour could be controlled by maintaining acidic environment. At the pH of 3, yellow colour of extract was obtained, meanwhile at neutral pH, the colour of extract changed into dark brown. PSA result showed that optimum stirring condition of precipitation process was obtained using 500 rpm stirring rate for 45 minutes which resulted in curcumin nanoparticle in the size range of 164.37±3.29 nm. Thus, by controlling the pH of extract at 3 during extraction process and using optimum stirring condition at 500 rpm for 45 minutes during precipitation process, more stable and soluble curcumin was successfully produced. A B S T R A KKurkumin merupakan salah satu senyawa aktif yang terkandung dalam ekstrak temulawak (Curcuma xanthorrhiza Roxb.) yang banyak digunakan untuk aplikasi biomedis. Meskipun demikian, pemanfaatan kurkumin masih terbatas dikarenakan sifatnya yang hidrofobik, stabilitas yang rendah, serta kelarutan di air yang rendah. Modifikasi kurkumin serta optimisasi proses ekstraksi maupun purifikasi perlu dilakukan untuk mengatasi kelemahan tersebut. Salah satu pendekatan yang dapat dilakukan adalah dengan membuat kurkumin dalam ukuran nano. Penelitian ini bertujuan untuk mengoptimasi pembuatan nanopartikel kurkumin dari ekstrak Curcuma xanthorrhiza Roxb. menggunakan metode presipitasi solven-antisolven. Stabilitas warna kurkumin dijaga dengan mengontrol pH saat persiapan bahan baku. Hasil nanopartikel kurkumin yang didapat kemudian dianalisis menggunakan particle size analysis (PSA). Hasil menunjukkan bahwa warna ekstrak Curcuma xanthorrhiza Roxb. dapat dijaga pada kondisi asam. Pada pH 3, ekstrak berwarna kuning cerah sedangkan pada pH netral, warna ekstrak berubah menjadi coklat gelap. Hasil PSA menunjukkan bahwa kondisi pengadukan yang optimum pada saat proses presipitasi diperoleh menggunakan kecepatan pengadukan 500 rpm selama 45 menit yang menghasilkan nanopartikel kurkumin dengan ukuran 164,37±3,29 nm. Dengan mengontrol ekstrak pada pH 3 selama proses ekstraksi dan menggunakan kondisi pengadukan optimum pada 500 rpm selama 45 menit pada proses presipitasi, kurkumin dengan stabilitas dan kelarutan yang baik dapat diperoleh.

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“…Pada media dasar MS dengan penambahan BAP 0,5 mg/l (kontrol), pertumbuhan kultur terkonsentrasi pada pembentukan tunas-tunas terlebih dahulu, daun yang terbentuk berukuran kecil-kecil tetapi jumlahnya banyak dan berwarna hijau. Kandungan mineral hara K yang terdapat pada air kelapa dapat mempengaruhi pertumbuhan tanaman (Nihayati et al, 2013) Hadipoentyanti et al (2008) penambahan BAP 0,5 mg/l dan air kelapa 10% terhadap media dasar alternatif kurang memberikan hasil yang diharapkan. Tunas yang terbentuk sedikit dengan daun yang menguning.…”

Section: Pembentukan Tunas Pada Media Dasar Alternatif Dengan Penambaunclassified

PERBANYAKAN NILAM (Pogostemon cablin Benth) MENGGUNAKAN MEDIA DASAR ALTERNATIF SECARA IN VITRO In vitro multiplication of Patchouli uses alternative primary medium

Amalia¹

2019

PSP

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Benih sangat menentukan dalam keberhasilan usahatani nilam. Perbanyakan benih secara konvensional vegetatif sangat mudah menularkan penyakit dan membutuhkan waktu yang relatif lama, seperti benih nilam yang diperbanyak selama ini dengan setek. Cara ini memiliki kendala, yang diharapkan dapat diatasi dengan teknik kultur jaringan. Media merupakan faktor utama dalam perbanyakan kultur jaringan. Perbanyakan dan perkembangbiakan tanaman nilam dengan metode kultur jaringan secara umum sudah dapat dilakukan tetapi untuk keberhasilannya sangat tergantung pada jenis media, terutama bila ditinjau dari sisi ekonomi. Karena aplikasi teknologi kultur jaringan untuk tanaman nilam masih dirasakan mahal. Tulisan ini mengulas tentang penggunaan media untuk menekan biaya media kultur jaringan yaitu dengan menggantikan media dasar MS (Murashige-Skoog), ZPT dan vitamin dengan media dasar alternatif dan air kelapa 10%. Air kelapa merupakan salah satu diantara beberapa persenyawaan kompleks alamiah yang sering digunakan dalam kultur jaringan. Sedangkan media dasar alternatif berupa pupuk daun dapat berfungsi sebagai penyedia unsur hara makro mikro dengan komposisi N:P:K (20:20:20). Hal ini untuk mengatasi permasalahan, agar media kultur jaringan menjadi relatif murah, dan harga jual benih lebih terjangkau. Air kelapa yang digunakan berasal dari kelapa hijau yang dicirikan dengan volume air masih memenuhi buah dan keadaan endosperm (daging kelapa) yang belum menebal. Tetapi meski bahan alternatif ini sudah banyak digunakan untuk media pengganti kultur jaringan karena relatif mudah tersedia, murah, menghasilkan benih seragam dan sehat, ternyata belum dapat menunjukkan hasil yang setara dibandingkan dengan penggunaan media MS dalam perbanyakan tunas nilam secara kultur jaringan. Oleh karena itu berbagai penelitian perbanyakan tanaman nilam dengan berbagai metode kultur jaringan agar menghasilkan benih yang murah, sehat, seragam dan dalam jumlah besar masih perlu terus diupayakan. ABSTRACT The quality of seeds are very important in patchoulli cultivation. Cutting multiplication seeds are usually easy in transmitting diseases and relatively need a long time to grow. So far patchouli seeds obtained conventionally with cutting has some constraints, hence tissue culture techniques becomes the solution once. The success of propagation and breeding of plants with tissue culture methods in patchouly is already conducted but is still expensive to be implemented. The paper review patchouli tissue culture propagation by replacing basic media MS (murashige-skoog, Growth Regulating Substances (GRS) and vitamine with alternate basic medium and 10% coconut water Coconut water is one of several natural complex compounds that are often used in tissue culture. The alternative medium as leaf fertilizer can serve as a micro and macro nutrient provider with composition N: P: K (20:20:20). Hopefully, It could become the solution to make tissue culture of patchoulli seeds cheaper and more available. Actually, eventhough the overall substitution of MS medium with full alternative media has already used in limited areas, it has not able yet showing equal results with the use of basic medium MS media in tissue culture patchouli multiplication. Therefore, the researches on patchouli tissue culture should be continued to achieve the huge number, healthy, unity, and unexpensive seeds.

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THE CURCUMIN CONTENT OF TEMULAWAK(Curcuma xanthorriza Roxb.) RHIZOME AS AFFECTED BY N, K AND MICRONUTRIENTS B, Fe, Zn

Cited by 8 publications

References 3 publications

Zingiberaceae extracts for pain: a systematic review and meta-analysis

Zingiberaceae extracts for pain: a systematic review and meta-analysis

Synthesis of Curcumin Nanoparticle from Curcuma xanthorrhiza Roxb Extract by Solvent-Antisolvent Precipitation Method

PERBANYAKAN NILAM (Pogostemon cablin Benth) MENGGUNAKAN MEDIA DASAR ALTERNATIF SECARA IN VITRO In vitro multiplication of Patchouli uses alternative primary medium

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