2024
DOI: 10.20944/preprints202404.0994.v1
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The Curious Role of PAI‐1 in Severe OSA

Tea Friščić,
Edvard Galić,
Domagoj Vidović
et al.

Abstract: Plasminogen activator inhibitor-1 (PAI-1) has a significant role in fibrinolysis, atherogenesis, cellular senescence, and chronic inflammation. OSA (obstructive sleep apnea) leads to increased PAI-1 levels and the development of cardiovascular disease (CVD). The aim of this study was to determine the effects of CPAP therapy in patients with severe OSA on coagulation parameters and PAI-1. This prospective, controlled study enrolled 57 patients who were newly diagnosed with severe OSA, 37 of whom had had a good … Show more

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