The current advances of lncRNAs in breast cancer immunobiology research

Abstract

Breast cancer is the most frequently diagnosed malignancy and the leading cause of cancer-related death in women worldwide. Breast cancer development and progression are mainly associated with tumor-intrinsic alterations in diverse genes and signaling pathways and with tumor-extrinsic dysregulations linked to the tumor immune microenvironment. Significantly, abnormal expression of lncRNAs affects the tumor immune microenvironment characteristics and modulates the behavior of different cancer types, including breast cancer. In this review, we provide the current advances about the role of lncRNAs as tumor-intrinsic and tumor-extrinsic modulators of the antitumoral immune response and the immune microenvironment in breast cancer, as well as lncRNAs which are potential biomarkers of tumor immune microenvironment and clinicopathological characteristics in patients, suggesting that lncRNAs are potential targets for immunotherapy in breast cancer.

Ramifications of m6A Modification on ncRNAs in Cancer

“…Dysregulation of lncRNAs has been implicated in many diseases, including cancer where they have both oncogenic and tumorsuppressive roles (167). As important players in the complex landscape of cancer biology lncRNAs regulate cancer development and metastasis (168); therefore, functional modification including m6A will have impact on their roles. Some lncRNAs promote oncogenic signaling by enhancing cell proliferation, blocking cell apoptosis, and facilitating cell invasion and metastasis.…”