Nervousness is thought to be a source of confusion, instability, or uncertainty in SC systems due to disruptions and frequent changes in decisions. Nervousness persists even with consistent SCs, which arise from planning flexibility in response to changes, where responsiveness and customer satisfaction balance. Although the term “nervousness” is well known, to our knowledge no prior research has examined and explored supply chain nervousness strategies (SCNSs). This research explores supply chain nervousness strategies, factors, reduction methods, and recent trends in the supply chain’s relationship with nervousness. The main purpose of this research is to determine the comprehensive and relevant nervousness strategies in the supply chains, especially in light of the unprecedented development and change in business, economics, and technology and the fierce competition. SCN strategies are introduced in a developed model to designate SCN measurements and indicators, mitigation strategies and stages, and management strategies. The fuzzy PROMETHEE method is employed to rank the strategies based on their importance and order of implementation. The suggested method for managing nervousness is then presented with a numerical case, along with the results. The research outcomes indicate that the top five strategies for managing nervousness include planning continuity, utilizing technology, managing nervousness, improving the SC cyber system, and managing supplies. The findings assist decision makers, practitioners, and managers in focusing on SC improvement, resilience, and sustainability.