The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

Abulehia, Hala F. S.; Nor, Noor Shafina Mohd; Kadir, Siti Hamimah Sheikh Abdul

doi:10.3390/nu14132766

Cited by 15 publications

(4 citation statements)

References 74 publications

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“…For example, exposure to bisphenol A (BPA), a chemical found in some plastics, has been associated with an increased risk of MetS in adolescents. BPA can disrupt hormone signaling pathways, leading to alterations in glucose and lipid metabolism, which are components of MetS ( Trasande et al, 2012 ; Wu et al, 2020 ; Abulehia et al, 2022 ).…”

Section: Adolescencementioning

confidence: 99%

Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective

et al. 2023

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Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central nervous system (CNS) and neurological development. MetS can last several years or be lifelong, affecting the CNS in different ways and treatments can help manage condition, though there is no known cure. The early childhood years are extremely important in neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic changes take place all life through — childhood, adolescence, adulthood, and old age — are highly sensitive to environmental input. Environmental factors have an important role in the etiopathogenesis and treatment of MetS, so environmental enrichment (EE) stands as a promising non-invasive therapeutic approach. While the EE paradigm has been designed for animal housing, its principles can be and actually are applied in cognitive, sensory, social, and physical stimulation programs for humans. Here, we briefly review the central milestones in neurodevelopment at each life stage, along with the research studies carried out on how MetS affects neurodevelopment at each life stage and the contributions that EE models can provide to improve health over the lifespan.

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Section: Adolescencementioning

confidence: 99%

Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective

et al. 2023

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“…A substantial body of literature has revealed that higher exposure to BPA can negatively affect human health ( 65 , 66 ). However, other studies have also revealed that the effect of prenatal BPA exposure on metabolic outcomes is often monotonic, with different doses of exposure having various influences on metabolic parameters ( 67 ). Our finding, which did not align with most existing literature, could be partially explained by several factors, including the fact that we estimated MRS using an average of four metabolic parameters: waist circumference, fasting glucose, lipids, and blood pressure measures.…”

Section: Discussionmentioning

confidence: 99%

Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner

Zamora

Marchlewicz²,

Téllez‐Rojo³

et al. 2022

Front. Nutr.

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BackgroundExposure to prenatal bisphenol A (BPA) and Mediterranean Diet Score (MDS) has been linked to metabolic risk in child offspring. It remains unclear if independent and interactive effects persist in adolescence.MethodsWe examined prenatal BPA and MDS on adolescent offspring metabolic syndrome risk score (MRS) and 8-isoprostane (8-iso), a biomarker of oxidative stress. Data from maternal-adolescent dyads from a Mexico City cohort were utilized, including trimester-specific prenatal BPA from spot urine and MDS from food frequency questionnaires. Offspring socio-demographic data and biomarkers to estimate MRS and 8-iso were obtained during peri-adolescence.ResultsAdjusted linear regression models examined associations between trimester-specific BPA, MDS, and BPA*MDS on outcomes. Sex-stratified analyses revealed a significant association between MDS with increased 8-iso (β = 0.064, p < 0.05), and a marginal association between trimester two BPA with increased 8-iso (β = 0.237), while MDS modified the marginal association between BPA and 8-iso in females (β = 0.046). A negative, marginal association was observed between trimester two BPA and MRS (β = – 0.728), while BPA * MDS was marginally, positively associated with MRS (β = 0.152) in males.ConclusionsStudy findings indicate that trimester two prenatal BPA and maternal adherence to a Mediterranean diet may have sexually dimorphic effects on adolescent offspring oxidative stress and metabolic syndrome risk.

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“…One such chemical is BPA. Human exposure to BPA has been linked to adverse health effects including obesity (20). In rodents, fetal BPA exposure causes the size of adipocytes increase with age, resulting in a larger body fat percentage (21).…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A and its Analogues Alter Appetite Control in Zebrafish

Karim,

Bondesson

2024

Preprint

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The regulation of appetite is of growing interest due to the significant rise in global obesity rates. Hunger and satiety are controlled by two hormones with functional activity in the brain; leptin, which is produced in adipocytes and suppresses food intake, and ghrelin, which is produced and released mainly by the stomach and functions as an appetite-stimulatory signal. In this study, zebrafish-based in vivo assays were used to examine whether BPA and five of its analogues, BPAF, BPE, BPC, BPC-CL, and BPS affect appetite regulation. The effect of bisphenol exposure on eating behavior was first examined. Four to six days old zebrafish larvae were exposed to a concentration range of the bisphenols and 17β-estradiol, followed by being fed a stained egg yolk powder at day six. After an hour of feeding, the feed in the gut was imaged by microscopy. Quantitative PCR was used to analyze the gene expression of leptin and ghrelin, as well as eleven other genes involved in appetite control. Exposures to BPA, BPAF, BPE, BPC, BPC-Cl and BPS, resulted in increased amounts of feed in the gut of the larvae in a concentration dependent manner. The qPCR results suggested that leptin mRNA expression was downregulated with the increasing concentrations of BPA, BPAF and BPC-Cl, whereas ghrelin mRNA expression was upregulated. The expression of several additional anorexigenic genes were downregulated by BPAF and BPC-Cl exposure, whereas orexigenic genes were upregulated. In conclusion, bisphenol exposures resulted in an increased eating behavior in zebrafish larvae, which correlated to increased mRNA expression of appetite-stimulatory genes and decreased expression of satiety-inducing genes. In addition, the results suggest that zebrafish larvae can be used to efficiently assess obesogenic capacity of environmental pollutants.

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The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

Cited by 15 publications

References 74 publications

Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective

Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective

Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner

Bisphenol A and its Analogues Alter Appetite Control in Zebrafish

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