The Current Landscape of Bioactive Molecules against DENV: A Systematic Review

Abstract

With a 30-fold increase in incidence over the previous 50 years, dengue fever is now the most widespread viral disease transmitted by mosquitoes in the world. The intricate interaction of the human defense system, hereditary predisposition, and specific bitterness elements is more likely to be the pathogenesis of dengue. There are presently no viable treatments for dengue. Synthetic drugs which are used against this ailment also show major side effects. There must be a deeper understanding of the underlying mechanism generating severe symptoms to develop auguring markers, cutting-edge diagnostics, and treatments and finally a well-rounded and secure antiserum. Hence, the aim is to search for safer and more potent drugs derived from plants. Plants or herbs are mainly targeting replication or its enzyme or specific stereotypes, though an exact mechanism of phytoconstituents interfering with the viral replication is still undiscovered. The present attempt provided the update with the objective to bringing up forward pathophysiological eventualities involved in dengue virus along with the naturally derived treatment relevant to provide the impregnable therapy by evading the noxious symptoms for dengue fever. Governor’s plum, Cryptocarya chartacea, magnolia berry, and Chinese ginger are such plants exhibiting many effective phytoconstituents against DENV and can be further explored for novel drug discovery by medicinal scientists.

Antiviral Activity of an Indole-Type Compound Derived from Natural Products, Identified by Virtual Screening by Interaction on Dengue Virus NS5 Protein

“…Furthermore, considering that indole is a potent basic pharmacophore present in a wide variety of antiviral agents [ 45 ], it is also known that some indole derivatives have been effective and selective inhibitors of this virus replication [ 57 ]. In this sense, the design of antiviral drugs containing indole is useful for combating viral infections [ 42 ], and furthermore, its application is interesting if this type of compound is found in natural products, as compounds from these sources have prevented DENV from infiltrating the genome or act by reducing structural and non-structural proteins that are produced [ 58 ]. This supports our findings.…”

Management and Control of Dengue Fever through One Health Approach

“…Plant-based medicines contain bioactive compounds that possess antiviral, anti-inflammatory, and immunomodulatory properties, making them an advantageous addition to managing dengue fever. Many plants, including Arrabidaea pulchra, Andrographis paniculata, Mimosa catechu, Carica papaya, Azadirachta indica, Allium sativum, Ficus septica, and Quercus lusitanica, have shown potential activity against dengue fever treatment (Huang et al 2017;Ali-Seyed and Vijayaraghavan 2020;Ester et al 2020;Lim et al 2021;Dwivedi et al 2021;Altamish et al 2022;Babbar et al 2023). These plants contain diverse bioactive compounds, such as alkaloids, Phenolics and flavonoids, contributing to their therapeutic properties.…”

Opuntia ficus-indica (L.) Mill. - anticancer properties and phytochemicals: current trends and future perspectives

“…It is beneficial to focus on active phytochemicals for herbal therapy to minimize the adverse effects, as well as pathogenic resistance against antibiotics ( Kooti et al., 2017 ). Plants produce a large number of secondary metabolites that are biosynthetically derived from primary metabolites and are a major source of microbicides, insecticides, and a variety of pharmaceutical medications ( Garg et al., 2022 ; Babbar et al., 2023 ; Kumar et al., 2023 ). Medicinal plants or their secondary metabolites have played an essential role in human society for a long time in combating diseases, either directly or indirectly ( Greenwell and Rahman, 2015 ; Sharma et al., 2022 ).…”