The current perspective on tick-borne encephalitis awareness and prevention in six Central and Eastern European countries: Report from a meeting of experts convened to discuss TBE in their region

Kollaritsch, Herwig; Chmelík, V; Dontsenko, Irina; Grzeszczuk, Anna; Kondrusik, Maciej; Usonis, Vytautas; Lakos, András

doi:10.1016/j.vaccine.2011.04.061

Cited by 49 publications

(47 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the frequently cited arguments that socio-economic factors,[43–45] increasing awareness of the health authorities [46] or more frequent contacts with ticks due to large-scale agricultural activities [12] contribute to the TBE incidence rise are not particularly applicable in the case of RK.…”

Section: Discussionmentioning

confidence: 99%

Impact of air temperature variation on the ixodid ticks habitat and tick-borne encephalitis incidence in the Russian Arctic: the case of the Komi Republic

Токаревич

Тронин

Гнатив

et al. 2017

International Journal of Circumpolar Health

View full text Add to dashboard Cite

Background: The causes of the recent rise of tick-borne encephalitis (TBE) incidence in Europe are discussed. Our objective was to estimate the impact of air temperature change on TBE incidence in the European part of the Russian Arctic. Methods: We analysed the TBE incidence in the Komi Republic (RK) over a 42-year period in relation to changes in local annual average air temperature, air temperature during the season of tick activity, tick abundance, TBE-prevalence in ticks, tick-bite incidence rate, and normalised difference vegetation index within the area under study. Results: In 1998–2011 in RK a substantial growth of TBE virus (TBEV) prevalence both in questing and feeding ticks was observed. In 1992–2011 there was 23-fold growth of the tick-bite incidence rate in humans, a northward shift of the reported tick bites, and the season of tick bites increased from 4 to 6 months. In 1998–2011 there was more than 6-fold growth of average annual TBE incidence compared with 1970–1983 and 1984–1997 periods. This resulted both from the northward shift of TBE, and its growth in the south. In our view it was related to local climate change as both the average annual air temperature, and the air temperature during the tick activity season grew substantially. We revealed in RK a strong correlation between the change in the air temperature and that in TBE incidence. The satellite data showed NDVI growth within RK, i.e. alteration of the local ecosystem under the influence of climate change. Conclusions: The rise in TBE incidence in RK is related considerably to the expansion of the range of Ixodes persulcatus. The territory with reported TBE cases also expanded northward. Climate change is an important driver of TBE incidence rate growth.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of air temperature variation on the ixodid ticks habitat and tick-borne encephalitis incidence in the Russian Arctic: the case of the Komi Republic

Токаревич

Тронин

Гнатив

et al. 2017

International Journal of Circumpolar Health

View full text Add to dashboard Cite

show abstract

“…The TBEVs are subdivided into three sub-types, namely Siberian, Western European and Far Eastern viruses [8,9], the latter being responsible for the most severe forms of central nervous system (CNS) disorders associated with high fatality rates (5–20%) [10]. Despite the availability of several licensed inactivated vaccines and vaccination programmes [1,11], the incidence of TBEV infections is increasing across much of Central and Eastern European countries, currently with an estimated 9,000 cases per year [12,13,14]. …”

Section: Introductionmentioning

confidence: 99%

Attenuation of Tick-Borne Encephalitis Virus Using Large-Scale Random Codon Re-encoding

et al. 2015

View full text Add to dashboard Cite

Large-scale codon re-encoding (i.e. introduction of a large number of synonymous mutations) is a novel method of generating attenuated viruses. Here, it was applied to the pathogenic flavivirus, tick-borne encephalitis virus (TBEV) which causes febrile illness and encephalitis in humans in forested regions of Europe and Asia. Using an infectious clone of the Oshima 5–10 strain ("wild-type virus"), a cassette of 1.4kb located in the NS5 coding region, was modified by randomly introducing 273 synonymous mutations ("re-encoded virus"). Whilst the in cellulo replicative fitness of the re-encoded virus was only slightly reduced, the re-encoded virus displayed an attenuated phenotype in a laboratory mouse model of non-lethal encephalitis. Following intra-peritoneal inoculation of either 2.105 or 2.106 TCID50 of virus, the frequency of viraemia, neurovirulence (measured using weight loss and appearance of symptoms) and neuroinvasiveness (detection of virus in the brain) were significantly decreased when compared with the wild-type virus. Mice infected by wild-type or re-encoded viruses produced comparable amounts of neutralising antibodies and results of challenge experiments demonstrated that mice previously infected with the re-encoded virus were protected against subsequent infection by the wild-type virus. This constitutes evidence that a mammalian species can be protected against infection by a virulent wild-type positive-stranded RNA virus following immunisation with a derived randomly re-encoded strain. Our results demonstrate that random codon re-encoding is potentially a simple and effective method of generating live-attenuated vaccine candidates against pathogenic flaviviruses.

show abstract

“…However, consistently in most endemic countries, vaccination coverage is very low and inefficient to adequately reduce the TBE burden [11,12]. Yet, TBE vaccines are safe, efficacious and well tolerated and present the only real option of effective and successful prevention [2,13,14].…”

Section: Abstract: Health Economics • Tick-borne Encephalitis • Vaccimentioning

confidence: 99%

“…Ways to protect against the disease is wearing suitable clothes and shoes, using repellents, avoiding tick-infected areas and consuming adequately pasteurized dairy products. However, vaccination is the most effective and potentially most successful route to prevent TBE [12] and thus reducing the burden of TBE.…”

Section: Abstract: Health Economics • Tick-borne Encephalitis • Vaccimentioning

confidence: 99%

“…In some endemic countries with high TBE incidence, vaccination coverage is too low to control the disease effectively [12]. In 2006, vaccination coverage in terms of persons receiving one or two doses of vaccine was 6% in Lithuania, 11% in the Czech Republic, 12% in Sweden, 13% in Germany, 13% in Switzerland and 14% in Estonia [100].…”

Section: Vaccination Coveragementioning

confidence: 99%

See 1 more Smart Citation

Review of tick-borne encephalitis and vaccines: clinical and economical aspects

Smit¹,

Postma²

2014

Expert Review of Vaccines

View full text Add to dashboard Cite

Tick-borne encephalitis (TBE) disease is an increasing burden not only locally but also globally. In most endemic countries, vaccination coverage is too low to reduce the TBE burden significantly; however, vaccination is the most effective protection against TBE, with various vaccines currently available. In spite of rising awareness of TBE, little attention is directed toward the health economics of the disease. The purpose of the present review is to compile information on TBE and its explicit clinical and economical aspects. Given the scarcity of studies, the authors conclude that more attention is needed for health economics of TBE. Notably, this would help establish guidance on efficient policies for TBE prevention, reduce disease burden and achieve population health benefits.

show abstract

The current perspective on tick-borne encephalitis awareness and prevention in six Central and Eastern European countries: Report from a meeting of experts convened to discuss TBE in their region

Cited by 49 publications

References 36 publications

Impact of air temperature variation on the ixodid ticks habitat and tick-borne encephalitis incidence in the Russian Arctic: the case of the Komi Republic

Impact of air temperature variation on the ixodid ticks habitat and tick-borne encephalitis incidence in the Russian Arctic: the case of the Komi Republic

Attenuation of Tick-Borne Encephalitis Virus Using Large-Scale Random Codon Re-encoding

Review of tick-borne encephalitis and vaccines: clinical and economical aspects

Contact Info

Product

Resources

About