The Current State of Knowledge in Biological Properties of Cirsimaritin

Abstract

The search for natural plant-based products as new pharmacological alternatives to treat various human pathologies has taken on great importance for researchers and research laboratories. In this context, research has intensified to extract and identify natural molecules endowed with biological effects. The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation of this flavonoid from various natural sources, including medicinal plants such as Artemisia judaica, Cirsium japonicum, Lithocarpus dealbatus, Microtea debilis, and Ocimum sanctum, has been carried out and verified using different spectral techniques. Biological effect investigations are carried out with a wide variety of experimental models in vitro and in vivo and laboratory techniques. The results of these research works showed the biological properties of cirsimaritin including anticancer, antimicrobial, antidiabetic, antiparasitic, antioxidant, and anti-inflammatory effects. The mechanisms involved in the multiple activities of this molecule are diverse and include sub-cellular, cellular, and molecular levels. Indeed, this bioactive induces anti-inflammatory and antiproliferative effects by inhibiting cell membrane receptors, interference with signaling pathways, and inhibiting transcriptional factors such as Nf-κB involved in cell promotion and proliferation. In the light of these results, cirsimaritin appears as a promising and viable alternative natural bioactive drug to treat many pathological conditions.

HPLC-HESI-MS/MS Analysis of Phenolic Compounds from Cynoglossum tubiflorus Leaf Extracts: An Assessment of Their Cytotoxic, Antioxidant, and Antibacterial Properties

“…Tannins, triterpenes, triterpenoids, and flavonoids from many plants can cause irreversible inhibition of several resistant bacterial strains, including Staphylococcus species, by altering the bacterial cell membrane permeability and fluidity, leading to a final damaging effect on the bacterial cell membranes [ 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. The chemical analysis of the Cynoglossum tubiflorus leaf methanolic extract showed high contents of phenolic compounds, flavonoids, and lignans, such as chlorogenic acid, rosmarinic acid, cirsimaritin, kaempferol, and cinchonain Ib, described for their antibacterial activities [ 46 , 59 , 60 , 61 , 62 , 63 ]. For instance, kaempferol [ 64 ] has already been described as a compound that can destroy the bacterial membranes of S. aureus in a murine corneal infection model.…”

Analyses of phytochemical compounds in the flowers and leaves of Spiraea japonica var. fortunei using UV-VIS, FTIR, and LC-MS techniques

“…Cirsimaritin has been reported to possess multiple biological effects, including antimicrobial, anti-inflammatory, and antiproliferative properties. It can also be used as an antidiabetic [ 47 ]. Isorhamnetin has an extensive pharmacological effects such as cardiovascular protection, anti-inflammation, anti-tumor, anti-oxidation, anti-bacterial, and anti-virus.…”

Cirsimaritin Alleviates Dextran Sodium Sulfate-Induced Acute Colitis in Experimental Animals: A Therapeutic Approach for Inflammatory Bowel Disease

“…This inhibition, in turn, led to reduced levels of proinflammatory cytokines and decreased expression of iNOS and COX-2, effectively preventing inflammation induced by DSS in the colon. Furthermore, a recent study revealed that cirsimaritin exerts anti-inflammatory activity by inhibiting nitric oxide production, inducing the expression of nitric oxide synthase, and blocking various cytokines, including IL-6 and TNF-α ( Benali et al, 2022 ).…”