The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead

Abstract

Background and Objectives. Owing to the complexity and heterogeneity of tumors, cancer’s early diagnoses and treatment have become a provocation. Structure-specific recognition protein-1 (SSRP1) is a histone (H3-H4 or H2A-H2B) chaperone in chromatin-related processes such as transcription, cell cycle control, and DNA replication, reported in various tumor tissues. It may also be used as a biomarker. This study aimed to highlight the role of SSRP1 in cancer with a focus on the current progress and future perspective. Methods. We search PubMed and Web of Sciences with keywords “SSRP1” and “Cancer.” Only English literature was included, and conference papers and abstract were all excluded. Results. Transcription factors are classified into three groups based on their DNA binding motifs: simple helix-loop-helix (bHLH), classical zinc fingers (ZF-TFs), and homeodomains. The tumor-suppressive miR-497 (microRNA-497) acted as an undesirable regulator of SSRP1 upregulation, which led to tumor growth. The siRNA (small interfering RNA) knockdown of SSRP1 hindered cell proliferation along with incursion and glioma cell migration. Through the AKT (also known as protein kinase B) signaling pathway, SSRP1 silencing affected cancer apoptosis and cell proliferation. Conclusion. The MAPK (mitogen-activated protein kinase) signaling pathway’s phosphorylation was suppressed when SSRP1 was depleted. The effect of curaxins on p53 and NF-B (nuclear factor-κB), and their toxicity to cancer cells, is attributable to the FACT (facilitates chromatin transcription) complex’s chromatin trapping.

The identification of key genes and pathways in glioblastoma by bioinformatics analysis

“…Moreover, the levels of SSRP1 are notably higher in patients with high-grade glioma compared to those with low-grade glioma. 35 These findings indicate that SSRP1 may play a critical role in the progression of GBM. To further elucidate the involvement of SSRP1 in the advancement of GBM cells, various techniques, such as CCK-8 and EdU assays, as well as FACS analysis, have been employed.…”

Retracted: The Current Status of SSRP1 in Cancer: Tribulation and Road Ahead

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”

Functional study of chromatin factors uncovers strong lineage determining roles and divergent behaviours between normal and malignant haematopoiesis

“…Facilitates chromatin transcription (FACT) is a histone chaperone involved in replication, transcription, chromatin reorganisation, DNA damage repair and cell fate determination [228][229][230][231] . It can bind to all core histones 228 and potentially several noncanonical histones 231 .…”