The current trend of exosome in epithelial ovarian cancer studies: A bibliometric review

Baghban, Neda; Ullah, Mujib; Nabipour, Iraj

doi:10.3389/fphar.2023.1082066

Cited by 8 publications

(13 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They achieve this by containing proteins such as programmed death-ligand 1 (PD-L1), which interact with receptors on immune cells, suppressing their activity. Moreover, exosomes carry microRNAs regulating the expression of genes involved in immune function [ 138 ]. Additionally, cancer cells release exosomes promoting the activity of immunosuppressive cells like regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) [ 139 ].…”

Section: The Impact Of Tumor Derived Exosomes On Immune Suppression A...mentioning

confidence: 99%

Advances in 3D Culture Models to Study Exosomes in Triple-Negative Breast Cancer

Yousafzai,

El Khalki,

Wang

et al. 2024

Cancers

View full text Add to dashboard Cite

Breast cancer, a leading cause of cancer-related deaths globally, exhibits distinct subtypes with varying pathological, genetic, and clinical characteristics. Despite advancements in breast cancer treatments, its histological and molecular heterogeneity pose a significant clinical challenge. Triple-negative breast cancer (TNBC), a highly aggressive subtype lacking targeted therapeutics, adds to the complexity of breast cancer treatment. Recent years have witnessed the development of advanced 3D culture technologies, such as organoids and spheroids, providing more representative models of healthy human tissue and various malignancies. These structures, resembling organs in structure and function, are generated from stem cells or organ-specific progenitor cells via self-organizing processes. Notably, 3D culture systems bridge the gap between 2D cultures and in vivo studies, offering a more accurate representation of in vivo tumors’ characteristics. Exosomes, small nano-sized molecules secreted by breast cancer and stromal/cancer-associated fibroblast cells, have garnered significant attention. They play a crucial role in cell-to-cell communication, influencing tumor progression, invasion, and metastasis. The 3D culture environment enhances exosome efficiency compared to traditional 2D cultures, impacting the transfer of specific cargoes and therapeutic effects. Furthermore, 3D exosomes have shown promise in improving therapeutic outcomes, acting as potential vehicles for cancer treatment administration. Studies have demonstrated their role in pro-angiogenesis and their innate therapeutic potential in mimicking cellular therapies without side effects. The 3D exosome model holds potential for addressing challenges associated with drug resistance, offering insights into the mechanisms underlying multidrug resistance and serving as a platform for drug screening. This review seeks to emphasize the crucial role of 3D culture systems in studying breast cancer, especially in understanding the involvement of exosomes in cancer pathology.

show abstract

Section: The Impact Of Tumor Derived Exosomes On Immune Suppression A...mentioning

confidence: 99%

Advances in 3D Culture Models to Study Exosomes in Triple-Negative Breast Cancer

Yousafzai,

El Khalki,

Wang

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…These exosomes can contain proteins such as programmed death-ligand 1 (PD-L1) that interact with receptors on immune cells and suppress their activity [ 4 , 5 ]. Exosomes can also carry microRNAs that regulate the expression of genes involved in immune function [ 3 ]. Exosomes can promote the activity of immunosuppressive cells: Cancer cells can release exosomes that contain molecules that promote the activity of immunosuppressive cells such as regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) [ 5 ].…”

Section: Exosomes and Their Impact On Immune Suppression And Cancer P...mentioning

confidence: 99%

Role of CD9 Sensing, AI, and Exosomes in Cellular Communication of Cancer

Neda,

Sai Priyanka,

Mujib

2023

Int J Stem Cell Res Ther

View full text Add to dashboard Cite

Exosomes are small membrane-bound vesicles that are released by various types of cells, including cancer cells, and play a role in intercellular communication. CD9 is a protein that is involved in cell signaling and adhesion. It is found on the surface of various cells, including cancer cells, and has been implicated in the communication between cancer cells and their microenvironment. Exosomes are small membrane-bound vesicles that are released by cells and contain various bioactive molecules, such as proteins, lipids, and nucleic acids. Exosomes have been shown to play a role in intercellular communication, and they have been implicated in the progression of cancer. There is evidence to suggest that CD9 is involved in the packaging and release of exosomes by cancer cells. CD9 has been shown to be important for the formation of tetraspanin-enriched microdomains (TEMs) on the surface of exosomes. These TEMs are thought to be important for the sorting and packaging of specific molecules into exosomes. In summary, CD9 appears to play an important role in the communication between cancer cells and their microenvironment via exosomes. The precise mechanisms by which CD9 mediates this communication are still being investigated, but the involvement of CD9 in exosome packaging and uptake suggests that it may be a promising target for the development of novel cancer therapies. Furthermore, CD9 has been shown to be involved in the uptake of exosomes by recipient cells. For example, studies have shown that CD9-positive exosomes released by cancer cells can be taken up by other cancer cells, leading to the transfer of oncogenic molecules and the promotion of cancer progression.

show abstract

“…Using bibliometric analysis, we can obtain the research status, hotspots, and future research directions in this field [ 18 ]. At present, bibliometric analyses of many oncology and immunology studies have emerged in an endless stream [ 19 , 20 ], which have played a guiding role in the research in corresponding fields and have enabled scholars to gain a deeper understanding of the development of each field. A literature search revealed that although there are many studies in the field of renal xenotransplantation, there is no corresponding bibliometric analysis of the trends, countries, authors, keywords, or citations in this field.…”

Section: Introductionmentioning

confidence: 99%

Research prospects for kidney xenotransplantation: a bibliometric analysis

Yang,

Zhang,

Wei

et al. 2024

Renal Failure

View full text Add to dashboard Cite

Background Xenograft kidney transplantation has been receiving increasing attention. The purpose of this study is to use bibliometric analysis to identify papers in this research field and explore their current status and development trends. Methods Using the data in the Web of Science core database from Clarivate Analytics as the object of study, we used ‘TS = Kidney OR Renal AND xenotransplantation’ as the search term to find all literature from 1980 to 2 November 2022. Results In total, 1005 articles were included. The United States has the highest number of publications and has made significant contributions in this field. Harvard University was at the forefront of this study. Professor Cooper has published 114 articles in this field. Xenotransplantation has the largest number of relevant articles. Transplantation was the most cited journal. High-frequency keywords illustrated the current state of development and future trends in xenotransplantation. The use of transgenic pigs and the development of coordinated co-stimulatory blockers have greatly facilitated progress in xenotransplantation research. We found that ‘co-stimulation blockade’, ‘xenograft survival’, ‘pluripotent stem cell’, ‘translational research’, and ‘genetic engineering’ were likely to be the focus of attention in the coming years. Conclusions This study screened global publications related to xenogeneic kidney transplantation; analyzed their literature metrology characteristics; identified the most cited articles in the research field; understood the current situation, hot spots, and trends of global research; and provided future development directions for researchers and practitioners.

show abstract

The current trend of exosome in epithelial ovarian cancer studies: A bibliometric review

Cited by 8 publications

References 97 publications

Advances in 3D Culture Models to Study Exosomes in Triple-Negative Breast Cancer

Advances in 3D Culture Models to Study Exosomes in Triple-Negative Breast Cancer

Role of CD9 Sensing, AI, and Exosomes in Cellular Communication of Cancer

Research prospects for kidney xenotransplantation: a bibliometric analysis

Contact Info

Product

Resources

About