The curse of wealth – Middle Eastern countries need to address the rapidly rising burden of diabetes

Klautzer, Lisa; Becker, Joachim; Mattke, Soeren

doi:10.15171/ijhpm.2014.33

Cited by 72 publications

(57 citation statements)

References 16 publications

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“…Due to a higher incidence of the risk factors, the prevalence of diabetes is increasing worldwide, but more evidently in developing countries (Sherif and Sumpio, 2015). In the Middle East and North Africa Region, 1 in 10 adults have diabetes (Klautzer et al, 2014); the region has the highest prevalence of diabetes (10.9%). The International Diabetes Federation (IDF) estimated that there are 34.6 million people with diabetes in the Middle East and North Africa, a number that will almost double to 67.9 million by 2035 if concerted action is not taken to tackle the risk factors fuelling the epidemic of diabetes throughout the region (IDF, 2013).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Sayed¹,

Ezzat²,

Khalil³

et al. 2016

J. Med. Plants Res.

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Many of the health benefits associated withPolysaccharides from the plants were isolated using hot extraction method and then hydrolyzed. The polysaccharide hydrolysates were identified using high performance liquid chromatographic technique. Maximum yield of total polysaccharides identified were obtained from A 7 (12.04%), A 1 (8.51%), A 8 (8.03%), A 2 (5.32%) and A 6 (2.18%) respectively. The isolated polysaccharides were tested for antihyperglycemic activity in alloxan-induced diabetic rats and alpha glucosidase inhibitory activity. Chromatographic investigation of the polysaccharides recorded the presence of 18 saccharides, glucuronic acid, stachyose, galacturonic acid, sucrose, glucose, xylose, galactose, rhamnose, mannose, arabinose, fructose polyol, mannitol and sorbitol in the eight Aloe species, but their quantitative composition differed among the species. Glucuronic acid, stachyose and galacturonic acid were the major detected saccharides. The results of the biological activities revealed significant antihyperglycemic activities with variable degrees. After four weeks of daily administration, polysaccharides isolated from A. vera (A 1 ) and A. arborescens (A 2 ) were the most active with 40 and 44% reduction in blood glucose level, respectively. All the tested polysaccharides showed significant alpha glucosidase inhibitory activity with IC50 (µg/ml) 11.70, 14.60 and 15.80 for A 7 , A 6 and A 1 respectively. In conclusion, the tested polysaccharides contribute to the antidiabetic action of these Aloe species.

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Section: Introductionmentioning

confidence: 99%

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Sayed¹,

Ezzat²,

Khalil³

et al. 2016

J. Med. Plants Res.

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“…Middle East exhibits a high prevalence of metabolic syndrome (37), diabetes (38,39), and familial hypercholesterolaemia (40); these disorders along with the practice of consanguineous marriages has resulted in a pattern of dyslipidemia (low high-density lipoprotein cholesterol and high triglycerides) that is different from many other regions of the world (41). These lifestyle disorders have reached the proportion of public health crisis; this epidemic is primarily a consequence of recent environmental changes that have triggered the effect of pre-existing susceptibility genes via gene-environment interactions (42).…”

mentioning

confidence: 99%

Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population

Hebbar

Nizam

Melhem

et al. 2018

Journal of Lipid Research

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“…The cost of treatment for such individuals who have had long-standing diabetes and exhibit complications is relatively higher, thus putting a stress on healthcare resources. According to the International Diabetes Foundation, the Middle East and North Africa region spent US$13.6 billion in 2013 on diabetes, with UAE, Qatar, Kuwait and Bahrain spending the highest on a per person basis [105]. Despite the spending on healthcare, the problem of increasing diabetes incidence remains unresolved due to lack of awareness Table 3.…”

Section: T2d: An Arab Perspectivementioning

confidence: 99%

Genetics, Genomics and Personalized Medicine in Type 2 Diabetes: A Perspective on the Arab Region

Siddiqui

Tyagi

2015

Per. Med.

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Type 2 diabetes (T2D) is a wide-spread, chronic metabolic disorder, affecting millions of people worldwide. The epidemic of diabetes has placed a huge strain on public health, longevity and economy. T2D occurs as a result of both genetic and environmental factors and is heterogeneous in its presentation across individuals. This review gives an overview of the genetic variations identified by genome-wide association studies which predispose individuals to T2D and those which are responsible for variable drug response across patients, and the necessity to adopt a personalized approach to diabetes management. We also include a perspective on diabetes in Arabs, given the high incidence of T2D and consanguineous marriages, and the need to understand associated genetic components in this vulnerable population.

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The curse of wealth – Middle Eastern countries need to address the rapidly rising burden of diabetes

Cited by 72 publications

References 16 publications

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Chemical composition and evaluation of possible alpha glucosidase inhibitory activity of eight Aloe species

Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population

Genetics, Genomics and Personalized Medicine in Type 2 Diabetes: A Perspective on the Arab Region

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