2022
DOI: 10.1101/2022.07.08.499385
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The cut site specificity of the influenza A virus endoribonuclease PA-X allows it to discriminate between host and viral mRNAs

Abstract: Widespread shutoff of host gene expression through RNA degradation is an advantageous way for many viruses to block antiviral responses. However, viruses need to maintain expression of their own genes and host genes necessary for replication despite the RNA degradation. The influenza A virus host shutoff endoribonuclease PA-X solves this problem by discriminating between RNAs and sparing viral mRNAs and some host RNAs. To understand how PA-X distinguishes between RNAs, we identified and characterized PA-X cut … Show more

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