The cutting edge of neonatal anesthesia: the tide of history is changing

Kuratani, Norifumi

doi:10.1007/s00540-014-1817-7

Cited by 9 publications

(3 citation statements)

References 8 publications

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“… 31 Similarly, opioids are thought to be relatively benign in terms of apoptosis due to exposure to anaesthesia in the developing brain. Hence, Kuratani 32 revealed that neonatal anaesthesia is changing from hypnotic-based anaesthesia to opioid-based anaesthesia to minimize the risk of neuroapoptosis. However, these alternatives are not feasible, particularly for short procedures and older children.…”

Section: Discussionmentioning

confidence: 99%

Anaesthesia-Related Pediatric Neurotoxicity: A Survey Study

Yildiz¹,

Kozanhan²,

Aydoğan³

et al. 2022

Turk J Anaesthesiol Reanim

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Objective: Millions of children are exposed to anaesthetic drugs every day; however, the possible adverse effects of these agents on the central nervous system remain controversial. This study evaluated anaesthesiologists’ and pediatric surgeons’ knowledge and daily practices regarding anaesthesia-induced neurotoxicity. Methods: A survey consisting of 12 questions was sent to members of the Turkish Anaesthesiology and Reanimation Association and the Turkish Pediatric Surgery Association via the Google forms program. Results: A total of 202 anaesthesiologists and 51 pediatric surgeons participated in this survey. The results demonstrate that anaesthesiologists and surgeons are aware of the risk of anaesthesia-related neurotoxicity and are willing to take action. Approximately, half of the anaesthesiologists and pediatric surgeons expected to postpone operations lasting at least 3 hours for patients <3 years of age. Also, one-third of the anaesthesiologists would seek feasible and more reliable alternative anaesthetic strategies. Conclusions: More than two-thirds of the participants knew about the US Food and Drug Administration neurotoxicity warning; however, uncertainty about anaesthesia-related neurotoxicity is ongoing. Many questions remain unanswered. The results of large-scale prospective randomized studies to evaluate the effect of anaesthetics and surgery on the cognitive development of pediatric patients are needed.

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Section: Discussionmentioning

confidence: 99%

Anaesthesia-Related Pediatric Neurotoxicity: A Survey Study

Yildiz¹,

Kozanhan²,

Aydoğan³

et al. 2022

Turk J Anaesthesiol Reanim

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“…Their small size [Figure 1] calls for skill in vascular access and airway management, and their vulnerability to respiratory and cardiac events and their immature physiological adaptation need vigilance, rapid detection and correction. [1] There are additional problems of the transitional circulation, increased presence of co-morbidities and, importantly, the occurrence of apnoea in preterms. Neonatal surgery is associated with higher mortality than older children.…”

Section: Introductionmentioning

confidence: 99%

Anaesthetic concerns in preterm and term neonates

Subramaniam

2019

Indian J Anaesth

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Anaesthesia for neonates is a composite of good knowledge of neonatal and transitional physiology combined with skill in airway maintenance and vascular access. When the newborn is a preterm, the complexities of management increase due to the small size and accompanying issues such as bronchopulmonary dysplasia and apnoea. World over, the number of survivors of preterm birth is on the increase. We searched Pubmed for “Anesthesia, apnea, neonatal, neonates, physiology, preterm, spinal anesthesia”, as well as cross references from review articles. These babies have a high incidence of conditions warranting surgery (e.g., tracheoesophaeal fistula, congenital diaphragmatic hernia, anorectal malformations, incarcerated hernia, necrotising enterocolitis). The possibility of neurodevelopmental harm by anaesthetics is currently the topic of active research. In parallel, advances in paediatric anaesthesia equipment, use of regional and neuraxial anaesthesia and availability of monitoring have steadily increased the safety of anaesthesia in these tiny patients.

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“…Bu bebeklerde anestezinin spesifik etkisi, tekniği ve yönetimi hakkındaki bilgiler net değildir. 8,9 Bu çalışmada, YYBÜ'nün en önemli hasta grubunu oluşturan ve cerrahi operasyon geçiren 2.500 g ve altındaki bebeklerin anestezi ve cerrahi açıdan özelliklerinin ve 3 aylık sağkalımlarının değerlendirilmesi amaçlandı.…”

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Our Experiences with Anesthesia in Low Birth Weight Infants: Retrospective Study

KILIÇARSLAN¹,

EMİNOĞLU²,

Ata³

et al. 2022

Turkiye Klinikleri J Anest Reanim

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Yenidoğan hasta grubu, anestezi, cerrahi ve neonatal bakım açısından hâlâ pediatrik cerrahinin en zorlu hasta grubunu oluşturmaktadır. 1,2 Düşük doğum ağırlığı (DDA) tanımı, 2.500 g ve altı olan, yüksek morbidite ve mortalite riski taşıyan bebekleri tanım-lamak için kullanılır. Bu tanımlama, perinatal ve bebeklik dönemindeki olumsuz sonuçları tahmin etmek için önemlidir. 3 DDA'ya en sık prematürite ve/veya intrauterin gelişme geriliği sebep olmaktadır. DDA ile doğan bebekler, dünyadaki tüm doğumların yak-

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The cutting edge of neonatal anesthesia: the tide of history is changing

Cited by 9 publications

References 8 publications

Anaesthesia-Related Pediatric Neurotoxicity: A Survey Study

Anaesthesia-Related Pediatric Neurotoxicity: A Survey Study

Anaesthetic concerns in preterm and term neonates

Our Experiences with Anesthesia in Low Birth Weight Infants: Retrospective Study

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