2011
DOI: 10.1101/gad.179275.111
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The Cyc8–Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein

Abstract: The yeast Tup1-Cyc8 corepressor complex is recruited to promoters by DNA-binding repressors, but the mechanisms by which it inhibits expression of genes involved in various stress pathways are poorly understood. Conditional and rapid depletion of Tup1 from the nucleus leads to concurrent nucleosome depletion and histone acetylation, recruitment of coactivators (Swi/Snf, SAGA, and Mediator), and increased transcriptional activity. Conversely, coactivator dissociation occurs rapidly upon rerepression by Cyc8-Tup… Show more

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Cited by 127 publications
(157 citation statements)
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“…Similar to Groucho (Winkler et al, 2010), TPL function is associated with histone deacetylase interaction (Krogan et al, 2012;Wang et al, 2013). Nevertheless, it is proposed that the Cyc8-Tup1 complex in yeast acts by shielding activation domains and preventing transcription factors of recruiting coactivators (Wong and Struhl, 2011). In this complex, Cyc8 functions as a Tup1 adaptor (Tzamarias and Struhl, 1994).…”
Section: Kix8 and Kix9 Are Tpl Adaptor Proteinsmentioning
confidence: 99%
“…Similar to Groucho (Winkler et al, 2010), TPL function is associated with histone deacetylase interaction (Krogan et al, 2012;Wang et al, 2013). Nevertheless, it is proposed that the Cyc8-Tup1 complex in yeast acts by shielding activation domains and preventing transcription factors of recruiting coactivators (Wong and Struhl, 2011). In this complex, Cyc8 functions as a Tup1 adaptor (Tzamarias and Struhl, 1994).…”
Section: Kix8 and Kix9 Are Tpl Adaptor Proteinsmentioning
confidence: 99%
“…The error bars show the standard deviations from three independent experiments. cerevisiae (43). Upon glucose starvation, Atf1 binds UAS1 and suppresses Tup-mediated chromatin repression at UAS1 and UAS2 (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…The study by Wong and Struhl (2011) suggests a new model ( Fig. 1) that represents a paradigm shift in un- Figure 1.…”
Section: A New Model: Tup1-cyc8 Masks Activation Domainsmentioning
confidence: 99%
“…A variety of mechanisms have been proposed to explain how Tup1-Cyc8 confers repression on its target genes, and, at individual genes, different mechanisms appear to influence expression to varying degrees. A study by Wong and Struhl (2011) in this issue of Genes & Development sheds light on the mechanism of Tup1-Cyc8 action by providing a new explanation for how repression is achieved. While Tup1-Cyc8 has long been considered a corepressor complex, Wong and Struhl (2011) suggest that these proteins do not usually function by actively repressing transcription.…”
mentioning
confidence: 99%
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