The cyclobuta[b]quinoline alkaloid cyclomegistine from Teclea gerrardii I.Verd. (Toddalioideae: Rutaceae)

Coombes, Philip H.; Mwangi, Elizabeth M.; Peters, Byron K.; Crouch, Neil R.; Mulholland, Dulcie A.

doi:10.1016/j.bse.2009.05.009

Cited by 10 publications

(1 citation statement)

References 22 publications

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“…]quinolines ( 25) nobiline ( 26) and triterpene lupeol (27) were reported from stem bark of this plant specie (Figure 7) [24].…”

Section: Teclea Simplicifoliamentioning

confidence: 91%

Phytochemical Investigation and Antimicrobial Study of Some Selected Traditional Medicinal Plants from North Gondar Zone

2022

JTMA

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Teclea nobilis is one of an endemic species to Ethiopia. It is used as a traditional medicine to treat analgesics and other disorders. Although many species of the genus Teclea have been investigated for their chemical constituents, there is no much prior report on the investigation of chemical constituents of root of Teclea nobilis. Phytochemical screening of the C6 H14, CH2 Cl2 ,CH2 Cl2 /CH3 OH (1:1) and CH3 OH root extracts of the plant revealed the presence of alkaloids, flavonoids, terpenes, phenols, tannins and glycosides.Chromatographic separation using column chromatography of CH2 Cl2 /CH3 OH (1:1) result in isolation of three compounds namely compound TN1(0.06%), TN2(0.04%)and TN3(0.05%).Structure are proposed for Compound TN1 and compound TN2 .Compound TN3 was not fully characterized due to lack of adequate spectral data.

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“…]quinolines ( 25) nobiline ( 26) and triterpene lupeol (27) were reported from stem bark of this plant specie (Figure 7) [24].…”

Section: Teclea Simplicifoliamentioning

confidence: 91%

Phytochemical Investigation and Antimicrobial Study of Some Selected Traditional Medicinal Plants from North Gondar Zone

2022

JTMA

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Concise Synthesis of (±)‐Myrioneurinol Enabled by Sequential [2+2] Cycloaddition/Retro‐Mannich Fragmentation/Mannich Reaction

Zhang

Jiang

2022

Angewandte Chemie

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A concise total synthesis of (±)‐myrioneurinol has been achieved in 14 steps. An efficient AgSbF6/t‐BuCl‐catalyzed intramolecular [2+2] cycloaddition reaction of the alkynone‐tethered enamine was developed to prepare the highly strained cyclobutene. It was used in combination with a subsequent retro‐Mannich fragmentation/Mannich reaction to efficiently construct the tricyclic core of myrioneurinol.

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Concise Synthesis of (±)‐Myrioneurinol Enabled by Sequential [2+2] Cycloaddition/Retro‐Mannich Fragmentation/Mannich Reaction

Zhang

Jiang

2022

Angew Chem Int Ed

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A concise total synthesis of (�)-myrioneurinol has been achieved in 14 steps. An efficient AgSbF 6 /t-BuCl-catalyzed intramolecular [2+2] cycloaddition reaction of the alkynone-tethered enamine was developed to prepare the highly strained cyclobutene. It was used in combination with a subsequent retro-Mannich fragmentation/Mannich reaction to efficiently construct the tricyclic core of myrioneurinol.

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The cyclobuta[b]quinoline alkaloid cyclomegistine from Teclea gerrardii I.Verd. (Toddalioideae: Rutaceae)

Cited by 10 publications

References 22 publications

Phytochemical Investigation and Antimicrobial Study of Some Selected Traditional Medicinal Plants from North Gondar Zone

Phytochemical Investigation and Antimicrobial Study of Some Selected Traditional Medicinal Plants from North Gondar Zone

Concise Synthesis of (±)‐Myrioneurinol Enabled by Sequential [2+2] Cycloaddition/Retro‐Mannich Fragmentation/Mannich Reaction

Concise Synthesis of (±)‐Myrioneurinol Enabled by Sequential [2+2] Cycloaddition/Retro‐Mannich Fragmentation/Mannich Reaction

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