The cyclothymic temperament in healthy controls and familially at risk individuals for mood disorder: endophenotype for genetic studies?

Chiaroni, P.; Hantouche, E.; Gouvernet, J.; Azorin, Jean‐Michel; Akiskal, Hagop S.

doi:10.1016/j.jad.2003.12.010

Cited by 86 publications

(49 citation statements)

References 45 publications

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“…Akiskal claims that affective temperaments form the basis of MDs and defines five main affective temperaments (6) in a model aimed at identifying individuals at risk of MDs (7)(8)(9)(10)(11). It has recently been determined that depressive temperament is associated with frequent, recurrent, and severe depression that begins early; hyperthymic temperament is associated with bipolar disorder; and cyclothymic temperament is associated with early onset depression (12,13).…”

Section: Introductionmentioning

confidence: 99%

Affective Temperaments in Epilepsy

Yazıcı¹,

Yazıcı²,

Varoğlu³

et al. 2012

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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Section: Introductionmentioning

confidence: 99%

Affective Temperaments in Epilepsy

Yazıcı¹,

Yazıcı²,

Varoğlu³

et al. 2012

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…Με την οπτική ενός φάσματος της διπολικής δια-ταραχής, η κυκλοθυμική ιδιοσυγκρασία διανέμεται σε ανιούσα διάταξη σε υγιείς συγγενείς ασθενών από τη μονοπολική κατάθλιψη έως τις διπολικές διαταραχές, πιθανόν διαμορφώνοντας μια σύνδεση μεταξύ μορια-κής και συμπεριφορικής γενετικής. 81 Παραδόξως, έχει αναφερθεί ότι οι συμμετέχοντες στην ομάδα ελέγχου εμφανίζουν υψηλότερη υπερθυμική ιδιοσυγκρασία σε σύγκριση με τους συγγενείς διπολικών ασθενών. 39,82 Αυτό το εύρημα συμφωνεί με τα παραπάνω, αλλά βρίσκεται σε αντίθεση με τα αποτελέσματα άλλης έ-ρευνας η οποία επισημαίνει ότι ασθενείς με διπολική διαταραχή Ι και οι συγγενείς τους είχαν σημαντικά υ-ψηλότερη συχνότητα υπερθυμικής ιδιοσυγκρασίας από ό,τι η ομάδα ελέγχου.…”

Section: μελέτες οικογένειαςunclassified

Untitled

2017

Psychiatriki

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“…(Gottesman and Gould, 2003). Proposed endophenotypes in BPD include measures of cognitive function, personality, brain structure and function, neurophysiological parameters, circadian rhythm, and response to pharmacological challenge (Sobczak et al, 2002, Chiaroni et al, 2005, Hasler et al, 2006, Savitz and Ramesar, 2006, Arts et al, 2008, Thaker, 2008. These traits typically show lower heritabilities than the diagnosis of BPD, but might still prove useful in identifying susceptibility genes if they have a simpler genetic architecture that is more amenable to genetic dissection.…”

mentioning

confidence: 99%

Genetics of bipolar disorder

Smoller

Gardner-Schuster²

2007

Curr Psychiatry Rep

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Bipolar disorder is a mood disorder characterized by impairing episodes of mania and depression. Twin studies have established that bipolar disorder is among the most heritable of medical disorders and efforts to identify specific susceptibility genes have intensified over the past two decades. The search for genes influencing bipolar disorder has been complicated by a paucity of animal models, limited understanding of pathogenesis, and the genetic and phenotypic complexity of the syndrome. Linkage studies have implicated several chromosomal regions as harboring relevant genes, but results have been inconsistent. It is now widely accepted that the genetic liability to bipolar disorder reflects the action of many genes of individually small effect, a scenario for which linkage studies are poorly suited. Thus, association studies, which are more powerful for the detection of modest effect loci, have become the focus of gene-finding research. A large number of candidate genes, including biological candidates derived from hypotheses about the pathogenesis of the disorder and positional candidates derived from linkage and cytogenetic studies, have been evaluated. Several of these genes have been associated with the disorder in independent studies (including BDNF, DAOA, DISC1, GRIK4, SLC6A4, and TPH2), but none has been established. The clinical heterogeneity of bipolar disorder and its phenotypic and genetic overlap with other disorders (especially schizophrenia, schizoaffective disorder, and major depressive disorder) has raised questions about the optimal phenotype definition for genetic studies. Nevertheless, genomewide association analysis, which has successfully identified susceptibility genes for a variety of complex disorders, has begun to implicate specific genes for bipolar disorder (DGKH, CACNA1C, ANK3). The polygenicity of the disorder means that very large samples will be needed to detect the modest effect loci that likely contribute to bipolar disorder. Detailed genetic dissection of the disorder may provide novel targets (both pharmacologic and psychosocial) for intervention.Bipolar disorder (BPD) is a common and serious mental disorder characterized by severe mood symptoms, including episodes of mania or hypomania and depression, occurring with a typically cyclical course. Lifetime risk for BPD has typically been reported to be approximately 1%, though recent estimates are as high as 4%. (Kessler et al., 2005). The personal and societal costs of BPD are enormous: even among adequately-treated individuals, relapse is common and the disorder can be profoundly disabling, resulting in serious economic burden (Kessler et al., 2006) Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production pr...

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The cyclothymic temperament in healthy controls and familially at risk individuals for mood disorder: endophenotype for genetic studies?

Cited by 86 publications

References 45 publications

Affective Temperaments in Epilepsy

Affective Temperaments in Epilepsy

Untitled

Genetics of bipolar disorder

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