The CYP2B6 G516T polymorphism influences CD4 + T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon

Queiroz, Maria Alice Freitas; Laurentino, Rogério Valois; Amoras, Ednelza da Silva Graça; Araújo, Mauro Sérgio Moura de; Gomes, Samara Tatielle Monteiro; Lima, Sandra Souza; Vallinoto, Antônio Carlos Rosário; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo; Machado, Luiz Fernando Almeida

doi:10.1016/j.ijid.2016.12.002

Cited by 8 publications

(11 citation statements)

References 34 publications

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“…The results suggested that the presence of the IFN+874A allele confers susceptibility to HIV-1 infection and a decrease in the number of CD4 + T lymphocytes and the association of genotype 509TT of TGFβ with an increase in HIV-1 plasma viral load [ 71 ]. Finally, the CYP2B6 G516T polymorphism seems to affect the response to efavirenz treatment by reducing the quantity of T CD4 + lymphocytes among persons with a high degree of miscegenation who use antiretroviral therapy [ 72 ]. The amount of information presented is leading the VL to focus on the more promising results and expanding the investigated groups.…”

Section: The Impact Of Hiv-1 In the Brazilian Amazon: From Description To Current Timesmentioning

confidence: 99%

The Epidemiological Impact of STIs among General and Vulnerable Populations of the Amazon Region of Brazil: 30 years of Surveillance

Machado

Fonseca

Queiroz

et al. 2021

Viruses

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Sexually transmitted infections (STIs) represent a worldwide public health problem and, although many of them are curable, they continue to be neglected, especially in areas with a low human development index, such as in the northern region of Brazil. This review describes the results of 30 years of studies at the Virus Laboratory at the Federal University of Pará, including the prevalence and molecular epidemiology of HIV-1, HTLV-1/2, HPV, HBV, Treponema pallidum and Chlamydia trachomatis among urban and non-urban populations, and also in vulnerable groups in the Brazilian Amazon. Control strategies and challenges in preventing STIs are discussed considering this immense geographic region, where essential health services are unable to reach the entire population, especially the most vulnerable, such as female sex workers, people who use illicit drugs, remnants of quilombolos and indigenous communities.

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Section: The Impact Of Hiv-1 In the Brazilian Amazon: From Description To Current Timesmentioning

confidence: 99%

The Epidemiological Impact of STIs among General and Vulnerable Populations of the Amazon Region of Brazil: 30 years of Surveillance

Machado

Fonseca

Queiroz

et al. 2021

Viruses

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“…The CYP2B6 gene is involved in the metabolism of several drugs, including antiretrovirals and opioids, such as efavirenz and methadone. 47,48 The most frequently deficient allele of this gene is CYP2B6*6 (rs3745274), where homozygous and heterozygous carriers for this nonfunctional allele have demonstrated PM phenotypes for various drugs, such as those mentioned above.…”

Section: Cyp2b6mentioning

confidence: 99%

Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon

Fernandes¹,

Rodrigues²,

Maroñas³

et al. 2021

PGPM

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Introduction: The genetic admixture of the Brazilian population has considerable relevance to the implementation of the principles of pharmacogenomics (PGx), as it may compromise the extrapolation of data obtained in more homogeneous world populations. Purpose: This study aims to investigate a panel of 117 polymorphisms in 35 pharmacogenes, which contains label recommendations or clinical evidence by international drug regulatory agencies, in Amazonian Native American populations, and compare the results obtained with continental population data from the 1000 Genomes Project Consortium. Patients and Methods: The study population is composed of 109 Native American individuals from three Brazilian Amazon groups. The genotyping of the PGx polymorphisms was performed by allelic discrimination using TaqMan ® OpenArray Genotyping with a panel of 120 customized assays on the QuantStudio™ 12K Flex Real-Time PCR System. Results: Statistical differences within the Native American populations were observed regarding both genotypes and phenotypes of some genes of the CYP family. The discriminant analysis of principal components (DAPCs) between the NAM group and the continental populations of the 1000 Genomes Project resulted in the clustering of the three Native American populations. Additionally, in general, the NAM group was determined to be closely situated between East Asia, America, and South Asia groups, which enabled us to infer a genetic similarity between these populations. The DAPC analysis further demonstrated that eight polymorphisms and six polymorphisms were more relevant in differentiating the NAM from the continental populations and the NAM populations among themselves, respectively. Conclusion: Some investigated polymorphisms show differences among world populations, particularly with populations of European origin, for whom precision medicine protocols are primarily designed. The accumulated knowledge regarding these variations may assist in the design of specific protocols for Native American populations and populations admixed with them.

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“…Em pessoas vivendo com HIV que apresentaram mutação no gene CYP2B6 alelo G516T, verificou-se uma redução significativa na contagem de linfócitos TCD4+ com a administração de efavirenz. Nesse caso, recomenda-se o aumento da dose de efavirenz para que o fármaco seja efetivo (Queiroz et al, 2017). Em outro grupo envolvendo crianças vivendo com HIV que possuíam modificações nos genes CYP2B6 e CYP2A6, foi encontrado que 71,0% não apresentavam a concentração plasmática de efavirenz dentro da faixa terapêutica recomenda, sendo necessário o aumento de dose do efavirenz (Soeria-Atmadja et al, 2017).…”

Section: Polimorfismo Genéticounclassified

Alterações farmacocinéticas de antirretrovirais em situações especiais: uma revisão narrativa

Bernardes

Sales

Santos

et al. 2021

RSD

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O número de novos casos de infecção pelo HIV tem aumentado continuamente. No cenário mundial, nota-se a ampliação do acesso à terapia antirretroviral e, atualmente, 26 milhões de pessoas fazem uso de antirretrovirais. No Brasil, país que fornece acesso integral e gratuito aos antirretrovirais, cerca de 630 mil pessoas encontram-se em tratamento. O presente estudo tem o objetivo de descrever as alterações farmacocinéticas dos antirretrovirais em pacientes com condições fisiológicas distintas. Realizou-se um levantamento bibliográfico com estudos relativos ao uso de antirretrovirais em grupos específicos: extremos de idade (recém-nascidos e idosos), gravidez, doença hepática, doença renal crônica, doença cardiovascular, obesidade, alterações metabólicas, interações alimentares, uso e abuso de drogas lícitas e ilícitas e polimorfismo genético. Em determinadas situações, verificou-se alterações em parâmetros farmacocinéticos como absorção, distribuição, metabolismo e excreção, assim como, variações dos níveis plasmáticos dos antirretrovirais. Destaca-se nos grupos investigados, a importância do ajuste de dose para aumentar a efetividade dos antirretrovirais e proporcionar um tratamento mais adequado às pessoas vivendo com HIV.

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The CYP2B6 G516T polymorphism influences CD4 + T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon

Abstract: The CYP2B6 G516T polymorphism seems to affect the response to efavirenz treatment by reducing CD4 T-cell counts in patients with a high degree of miscegenation who use this antiretroviral agent.

Cited by 8 publications

References 34 publications

The Epidemiological Impact of STIs among General and Vulnerable Populations of the Amazon Region of Brazil: 30 years of Surveillance

The Epidemiological Impact of STIs among General and Vulnerable Populations of the Amazon Region of Brazil: 30 years of Surveillance

Genetic Diversity of Drug-Related Genes in Native Americans of the Brazilian Amazon

Alterações farmacocinéticas de antirretrovirais em situações especiais: uma revisão narrativa

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