The cytochemistry of the thyroid C cells and their relationship to calcitonin

doi:10.1098/rspb.1966.0044

Cited by 203 publications

(23 citation statements)

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“…Parathormone concentration decreased sharply within 10 minutes after calcium infusion and remained at a low level for a few hours (Zulliger, 2008) or days (Dumelin, 2002). Hypercalcaemia also causes calcitonin secretion from the thyroid (Pearse, 1966;Care et al, 1970) and in turn inhibits bone resorption and stimulates urinary excretion of calcium. These mechanisms may have accounted for the lower calcium concentrations from 24 to 72 hours in group B.…”

Section: Discussionmentioning

confidence: 99%

Treatment of cows with parturient paresis using intravenous calcium and oral sodium phosphate

Braun

Grob

Hässig

2016

SAT

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The goal of this study was to investigate whether intravenous infusion of 1000 ml 40% calcium borogluconate combined with the oral adminstration of 500 g sodium phosphate leads to a better cure rate and longer-lasting normocalcaemia and normophosphataemia than standard intravenous treatment with 500 ml calcium borogluconate in cows with parturient paresis. Forty recumbent cows with hypocalcaemia and hypophosphataemia were alternately allocated to group A or B. Cows of both groups were treated intravenously with 500 ml 40% calcium borogluconate, and cows of group B additionally received another 500 ml calcium borogluconate via slow intravenous infusion and 500 g sodium phosphate administered via an orogastric tube. Thirty-two cows stood within 8 hours after the start of treatment and 8 did not; of the 32 cows that stood, 18 belonged to group A and 14 to group B (90% of group A vs. 70% of group B; P = 0.23). Seven cows relapsed; of these and the 8 that did not respond to initial treatment, 10 stood after two standard intravenous treatments. Downer cow syndrome occurred in 5 cows, 3 of which recovered after aggressive therapy. The overall cure rate did not differ significantly between groups A and B. Twelve (60%) cows of group A and 14 (70%) cows of group B were cured after a single treatment and of the remaining 14, 11 were cured after two or more treatments. Two downer cows were euthanized and one other died of heart failure during treatment. Serum calcium concentrations during the first eight hours after the start of treatment were significantly higher in group B than in group A, and oral sodium phosphate caused a significant and lasting increase in inorganic phosphate. More cows of group B than group A were cured after a single treatment (P > 0.05). These findings, although not statistically significant, are promising and should be verified using a larger number of cows. DOI: https://doi.org/10.17236/sat00081Other titles: Behandlung der Gebärparese von Kühen mit Kalzium intravenös und Natriumphosphat per os Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-130508 Veröffentlichte Version Originally published at: Braun, Ueli; Grob, Daniela; Hässig, Michael (2016). Treatment of cows with parturient paresis using intravenous calcium and oral sodium phosphate. Schweizer Archiv für Tierheilkunde, 158(9):615-622.

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Section: Discussionmentioning

confidence: 99%

Treatment of cows with parturient paresis using intravenous calcium and oral sodium phosphate

Braun

Grob

Hässig

2016

SAT

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“…These subcellular structures measured between 1500 and 2000 ~ in diameter and some contained electron-dense material which appeared as discrete granules. Pearse (1966) demonstrated that these cells were primarily epifollicular (oriented towards blood vessels rather than the follicular lumen) in pigs while in man these cells appear to be both epifollicular and parafollicular. He therefore referred to these ·cells as "C" cells to indicate their possible role in calcitonin secretion.…”

Section: Cell Of Originmentioning

confidence: 99%

Calcitonin Activity of Particulate Fractions of the Ovine Thyroid Gland

Oeltgen¹,

L'Heureux²

1975

Horm Metab Res

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Mitochondria, nu dei, and microsomes obtained from ovine thyroid slices wh ich had been incubated in Krebs-Ringer bicarbonate buffer containing 4.8, 11.5 or 26.0 mg% concentration of calcium were assayed for calcitonin activity in rats. The microsomal preparatioa was the only particulate fraction to exhibit marked hypocalcemic activity and the hormonal activity of this fraction was enhanced by a 26.0 mg% calcium concentration in the incubation medium. The identity of the hypocalcemic species in the microsomal fraction with a calcitonin preparation 01' known potency was established by polyacrylamide gel eletrophoresis and by isoelectric focusing. The ovine microsomal calcitonin was resolved into two pro tein bands with isoelectric points (pl's) of 3.49 and 3.84. Both of these protein peaks exhibited hypocalcemic activity. The porcine standard calcitonin was resolved into two protein bands with pl's of 3.70 and 3.94.

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“…The term "C-cells" was introduced by Pearse and later on with Bussolati demonstrated the presence of calcitonin in these cells by immunofluorescence. Interestingly, parallel to all these discoveries (5,6) in the early 1960s, pathologists were defining the morphology of the tumor now known as medullary thyroid carcinoma (MTC) (7,8). In 1966, Williams proposed that MTC might be derived from the C cell and predicted that if the C cell was the source of calcitonin, the tumors might also produce this hormone (9).…”

Section: Historical Perspectivementioning

confidence: 99%

C-cells and their associated lesions and conditions: a pathologists perspective

Baloch¹,

LiVolsi²

2015

TJPATH

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This paper updates the histopathology and cytopathology of thyroid tumors and proliferations derived from the para-follicular or C cells. Beginning with an historical over view, including the recognition of medullary thyroid carcinoma as a distinct histologic entity, its relationship to the hormone, calcitonin, (which was discovered in the same decade) and to thyroid C cells, medullary carcinoma and its variants are reviewed. The molecular biology of the tumors and the associated mutations in the tumors (somatic mutations) are discussed. Additionally the genetic features (germline mutations) including familial clusters and associations with other endocrine and neuroendocrine lesions are reviewed. Screening for the tumor and its precursors is included with a review of the latest American Thyroid Association guidelines for treatment as well as timing and approach to surgery. Tabular data of specific germline mutations and their relationships to tumor virulence, and prognosis are illustrated. Precursor and early C cell lesions such as C-cell hyperplasia and micro-medullary carcinoma are discussed. Difficulties and controversies in the definition of C-cell proliferations which are neoplastic and those which are "reactive" are reviewed. The entity of medullary microcarcinoma or medullary microcarcinoma is illustrated and the distinction between C cell nodules and microcarcinoma is defined using the latest available criteria. Finally the latest approved chemotherapeutic agents and their results in metastatic medullary thyroid carcinoma are included.

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The cytochemistry of the thyroid C cells and their relationship to calcitonin

Cited by 203 publications

References 9 publications

Treatment of cows with parturient paresis using intravenous calcium and oral sodium phosphate

Treatment of cows with parturient paresis using intravenous calcium and oral sodium phosphate

Calcitonin Activity of Particulate Fractions of the Ovine Thyroid Gland

C-cells and their associated lesions and conditions: a pathologists perspective

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