The Cytological Diagnosis of Bladder Tumours Amongst Dyestuff Workers

Crabbe, J. G. S.; Cresdee, W. C.; Scott, T. S.; Williams, M. H. C.

doi:10.1136/oem.13.4.270

Cited by 29 publications

(10 citation statements)

References 13 publications

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“…The value of a simple RBC count in urinary sediment (wet smear) as a screening test for bladder carcinoma in an at-risk population was assessed by Crabbe et al in 1956, when they examined the urine of 1800 dyestuff workers over a 5-year period.…”

Section: Discussionmentioning

confidence: 96%

Diagnostic Efficacy of the Combination of Urine Cytology, Urine Analysis and History in the Follow-Up of Bladder Carcinoma

Meuleman

Delaere

1989

Journal of Urology

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In the follow-up of low stage, low grade transitional cell carcinoma of the bladder, cystoscopy is used as a diagnostic standard. Because of the lack of well defined prognostic parameters, cystoscopic follow-up is based upon empirical grounds. studied with respect to the time interval before recurrence. The mean number of cystoscopies leading to detection of recurrence (Le. the ratio of positive to negative cystoscopy) was reviewed. Eighteen cystoscopies had to be done to detect each recurrence. Because of this excessive number of cystoscopies, the diagnostic value of the combination of red cell count in urine, cytology and history of micturition symptoms and haernaturia was assessed in a retrospective study of 86 recurrences of bladder carcinoma. The results indicated that the combination of these non-invasive diagnostic tests may constitute a sensitive procedure for the follow-up of bladder tumours. In the case of T1G3 and muscle-invasive recurrences ( > T l ) , the sensitivity rate was 100%.

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Section: Discussionmentioning

confidence: 96%

Diagnostic Efficacy of the Combination of Urine Cytology, Urine Analysis and History in the Follow-Up of Bladder Carcinoma

Meuleman

Delaere

1989

Journal of Urology

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“…The reports of urine preparations were divided into the following categories: 1 Tables 1 and 2 show the results based on the histological analysis of the subsequently diagnosed urinary tract lesions. Of the 31 patients with confirmed malignancy, 27 were correctly identified by urine cytology processed using method 1, resulting in a sensitivity of 87%.…”

Section: Calculation Of Resultsmentioning

confidence: 99%

Comparison of two preparatory techniques for urine cytology.

Dhundee

Rigby

1990

J Clin Pathol

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Two methods of preparation of urine for cytology were compared retrospectively. In method 1 cells in the urine were fixed after the preparation of the smear; in method 2 the cells were fixed before smear preparation. Urine cytology reports were correlated with subsequent histological analysis. The specificities of urine cytology using both methods were high (99%). The sensitivity using method 1 was 87%; using method 2 it was 65%. This difference was significant. The cell preparation technique therefore significantly changes the sensitivity of urine cytology. Cellular fixation after smear preparation is preferable to smear preparation after fixation.The importance of urine cytology for the detection of urological malignancy is well established.l" Exfoliated cells in a urine sample, especially single cells, deteriorate rapidly and degenerative changes are seen within one hour.5 To permit optimal visualisation of the sample it is important, therefore, to have a high yield of well preserved cells, and to achieve this a variety of methods have been used."'0This retrospective study compares a method in which the cells are spray fixed after the smear is made with one in which fixation is undertaken before smearing. MethodsAll urine cytology reports for two six month periods were retrieved from the computer based files and compared. In the last six months of 1987 the specimens were fixed after the smear was made (method 1); in the last six months of 1988 the cells were fixed before smear preparation (method 2). The samples were received in an identical manner with that described in method 1. The entire sample was centrifuged at 1500 rpm for five minutes using an MSE Centaur 2 Centrifuge and the supernatant decanted. Fixative (5 ml) (25 ml glacial acetic acid, 20 ml methanol, 105 ml distilled water) was then added to the deposit of cells, mixed well, and allowed to stand for 30 minutes. The sample was respun, the supernatant decanted, and the sample processed in the cytospin (Shandon Cytospin 2) as in method 1. The slides were allowed to dry for two to three minutes and the preparation stained in an identical manner with that described in method 1. When haematuria was suspected, a wet preparation was made to look for red blood cells. CALCULATION OF RESULTSThe cytological diagnoses were correlated with the final histological diagnoses using interlinked computed records. The reports of urine preparations were divided into the following categories: 1 Positive cytology-this was subdivided into two subgroups clearly malignant and suspicious of malignancy. 2 Negative cytology-urine samples where no malignant cells were seen. 3 Inadequate specimen-any specimen in which the preparation was obscured by polymorphs, crystals, bacteria, squames, spermatozoa, or was poorly cellular, or consisted of degenerate cells. ResultsBetween July 1987 and December 1987 a total of 372 urine samples were examined. Of these samples, 297 (80%) were reported as negative, 30 (8%) as inadequate, 17 (5%) were suspicious of malignancy, and 28 (7...

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“…The value of exfoliative cytology in the diagnosis of cancer is firmly established in carcinoma of the cervix, vagina, uterus and bronchus and also in the recognition of malignant involvement of the pericardium, pleura, peritoneum and meninges. With increasing experience, it seems possible that similar techniques will be of value in the diagnosis of malignant disease of the urinary system (particularly bladder) (Crabbe, Cresdee, Scott and Williams, 1956;Poole-Wilson, 1959) and the stomach (Burnett, MacFarlane, Park and Kay, i960;Forrest, i960;Schade, 1958).…”

Section: The Management Of the Relativesmentioning

confidence: 99%

General Medical Aspects of Malignant Disease

Matthias

1961

Postgraduate Medical Journal

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The Cytological Diagnosis of Bladder Tumours Amongst Dyestuff Workers

Cited by 29 publications

References 13 publications

Diagnostic Efficacy of the Combination of Urine Cytology, Urine Analysis and History in the Follow-Up of Bladder Carcinoma

Diagnostic Efficacy of the Combination of Urine Cytology, Urine Analysis and History in the Follow-Up of Bladder Carcinoma

Comparison of two preparatory techniques for urine cytology.

General Medical Aspects of Malignant Disease

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