The cytology of intracranial clear cell meningioma with an unusual scalp presentation

Jayasree, K; Divya, KN

doi:10.4103/0970-9371.83469

Cited by 3 publications

(5 citation statements)

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“…In contrast, CCMs have spindled to polygonal cells in sheets with clear vacuolated d cytoplasm and bland-appearing nuclei with inconspicuous nucleoli. [ 4 ] On IHC, they show membranouspositivity for EMA and negativity for cytokeratin. [ 4 ] CCM should also be separated from hemangioblastoma the later present as a cyst with mural nodule having leptomeningeal attachment.…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 ] On IHC, they show membranouspositivity for EMA and negativity for cytokeratin. [ 4 ] CCM should also be separated from hemangioblastoma the later present as a cyst with mural nodule having leptomeningeal attachment. Cytologically it shows anastomosing network of blood vessels separated by stromal cells with medium to large nuclei having foamy cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…Increased mitosis and necrosis are unusual. [4,5] The differential diagnosis of CCM includes clear-cell ependymoma and metastasis of renal cell carcinoma (RCC). Clear-cell ependymomas are intra-axial and ventricular tumors, the squash smears of which show typical perivascular rosettes, poorly formed acini, cords and fibrillary processes of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

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Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature

et al. 2017

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Clear-cell meningioma (CCM), an unusual subset of meningioma has prominent, clear-cell morphology. It is a wolf in sheep's clothing characterized by benign histologic attributes, but tendency for recurrence (61%) and metastasis. Therefore, WHO has classified it as grade II meningioma. Fine-needle aspiration cytology diagnosis is simple, rapid, cost-effective and reliable procedure primarily aimed at preoperative diagnosis of advanced and metastatic extracranial tumor. Preoperative and/or intraoperative cytodiagnosis of CCM demand expertise in the evaluation of cytology smears. However in case of intra operative evaluation of squash smears there is a time constraint and a very small tissue material obtained by stereotactic biopsy are available for interpretation. Knowledge of clinical features including age, anatomical locations, neuroimaging findings and cytomorphologic features, are prerequisites for arriving at definitive cytodiagnosis. We describe intra operative squash cytology of CCM in a 16-year-old female, located in cerebello-pontine angle. The diagnosis of CCM offered on squash cytology was subsequently confirmed on histopathology and immunohistochemistry. It typically showed pattern less sheets and groups of polyhedral, clear cells with monomorphic, round nuclei having a bland chromatin and inconspicuous nucleoli. Separation of CCM from other tumors having clear -cell morphology and variants of meningioma is important because of its high recurrence rate and mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature

et al. 2017

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“…Terapi utama meningioma adalah reseksi tumor. 5,8 Penanganan meningioma dapat meliputi kombinasi dari observasi, reseksi melalui pembedahan, radioterapi, dan kemoterapi. 7 Pada umumnya meningioma termasuk tumor yang jinak dan berkembang dengan lambat.…”

Section: Pendahuluanunclassified

Meningioma pada akseptor kontrasepsi hormonal: laporan kasus

Saraswati¹,

Sudiariani²,

Astika³

et al. 2022

Intisari Sains Medis

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Background: Meningiomas are the most common primary central nervous system (CNS) tumors. The incidence of meningioma is mostly found in women. There is an association between hormones and the incidence of meningioma. The symptoms of meningioma are unspecified and depend on the tumor's location. This case study aims to evaluate meningioma in the hormonal contraceptive acceptor. Case Presentation: A 36-years-old female patient was hospitalized with a chronic progressive headache that occurred for approximately two months. It was a throbbing headache in the left area of the head that worsened in the lying position. The patients deny other symptoms, such as weakness on one side of the body, nausea, vomiting, blurred visions or double visions, or convulsions. The patient had a history of receiving hormonal contraception for over 10 years. CT with contrast reveals a strong contrast enhancement, a well-defined, round-shaped lesion in the left sphenoid wing. In this case, tumor resection was done. From the histopathological examination, chordoid meningioma was found. Based on WHO grading, chordoid meningioma belongs to WHO grade II. Conclusion: The longer exposure to the exogenous progesterone injection, the lower the expression of Progesterone Receptors (PR) and mRNA Neurofibromatosis-2 (NF2) in the serum, and that lower expression of PR and NF2 was significantly and independently associated with a higher risk of females to suffer from meningioma. Latar Belakang: Meningioma adalah tumor primer sistem saraf pusat (SSP) yang paling sering ditemukan. Insiden meningioma lebih banyak ditemukan pada wanita, dimana diduga ada keterkaitan hormon pada wanita dengan kejadian meningioma. Gejala meningioma seringkali tidak spesifik dan tergantung dari lokasi tumbuhnya tumor. Laporan kasus ini bertujuan mengevaluasi meningioma pada akseptor kontrasepsi hormonal. Presentasi Kasus: Pasien wanita berusia 36 tahun dirawat dengan keluhan nyeri kepala kronik progresif yang dialami selama kurang-lebih dua bulan. Keluhan dirasakan seperti berdenyut di kepala sebelah kiri, memberat dengan posisi berbaring. Keluhan lain seperti lemah separuh tubuh, mual, muntah, pandangan kabur atau ganda, serta kejang disangkal oleh pasien. Pasien memiliki riwayat penggunaan kontrasepsi hormonal injeksi setiap 3 bulan selama lebih dari 10 tahun. Pada pemeriksaan CT kepala dengan kontras didapatkan gambaran lesi menyangat kontras berbentuk bulat, berbatas tegas pada sphenoid wing kiri. Dilakukan reseksi tumor serta dilakukan pemeriksaan histopatologis dengan hasil chordoid meningioma, yang merupakan WHO derajat II. Simpulan: Semakin lama paparan terhadap progesteron eksogen injeksi, maka ekspresi Reseptor Progesteron (RP) dan mRNA Neurofibromatosis-2 (NF2) dalam serum akan semakin rendah yang secara signifikan dan independen berhubungan dengan risiko yang lebih tinggi bagi wanita untuk menderita meningioma.

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“…Meningioma is an encapsulated tumor in the central nervous system which originates from meningothelial arachnoid cells. 1,2 The majority of meningiomas are benign, yet it could be dangerous if the tumor expands and emerging causing an increase of intracranial pressure because of its intracranial location and often leads to headache, nausea, vomit, incoordination, and seizure. 3,4 Based on WHO, meningioma can be classified into 3 grades, i.e.…”

Section: Introductionmentioning

confidence: 99%

The Distribution of Meningioma in Dr. Hasan Sadikin General Hospital Bandung Period 2010–2013

Gunadi¹,

Suryanti²,

Yohana³

2018

amj

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Background: In neurological diseases, brain tumor is the second leading cause of death after stroke, of which the most common types of brain tumor is meningioma. There are many factors affect the prognosis of meningioma patient, including age, gender, location, and histopathological type of tumor. This study aimed to explore the distribution of meningioma based on age, gender, location of the tumor, and its histopathological type during the period of 2010-2013 in Dr. Hasan Sadikin General Hospital Bandung. Methods: This study was a quantitative descriptive study and data were collected from medical records of Department of Pathology between January 2010-December 2013. Age, gender, location, and histopathological type of meningioma were acquired. Results: There were 277 eligible cases of meningioma with an average number of cases per year were 69 cases. The ratio of men to women was 1:6.4. Meningioma was most commonly found in the age group 41-50 years (38.9%), and mostly located in convexity (55.96%). The most common histopathological type of meningioma was meningotheliomatous meningioma (70%). Conclusions: The frequency of meningioma is 6 times higher in women, predominantly around the age of 50 years old. Meningioma is most commonly found in convexity, and meningotheliomatous meningioma is the most common histopathological type.

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The cytology of intracranial clear cell meningioma with an unusual scalp presentation

Cited by 3 publications

References 5 publications

Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature

Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature

Meningioma pada akseptor kontrasepsi hormonal: laporan kasus

The Distribution of Meningioma in Dr. Hasan Sadikin General Hospital Bandung Period 2010–2013

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