The Cytosolic Acidification in Rat Parotid Cells Is Associated with an Increase in Cytosolic Ca2+ Concentration

Narita, Minoru; Takahashi, Yuki; Takamori, Kazuaki; Funada, Masahiko; Suzuki, Tsutomu; Misawa, Miwa; Nagase, Hiroshi

doi:10.1254/jjp.62.15

Cited by 58 publications

(32 citation statements)

References 39 publications

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“…12,66,67 In contrast to the d-receptor, the k-receptor has been shown to be countermodulatory in interacting with m-and d-receptor, including modulating and reducing dopaminergic tone. 14,15 Several published studies, including two of our previous studies (discussed in Zhang et al 37 ), have demonstrated an association between m-receptor gene (OPRM1) variants and AD and/or DD. Meta-analysis showed no association of one polymorphism, A118G, Abbreviations: AD, alcohol dependence; CD, cocaine dependence; Con, normal controls; DD, drug dependence; EM, expectation-maximization; OD, opioid dependence; SNP, single nucleotide polymorphism.…”

Section: Discussionmentioning

confidence: 96%

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The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

et al. 2007

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Eleven single-nucleotide polymorphisms (SNPs) spanning OPRD1 were examined in 1063 European Americans (EAs) (620 cases with substance dependence (SD), including 557 with alcohol dependence (AD), 225 with cocaine dependence (CD) and 111 with opioid dependence (OD), and 443 controls). Nominally significant associations (P < 0.05) of five SNPs with SD were observed; only the association of the non-synonymous variant G80T with OD remained significant after correction for multiple testing using SNPSpD. Haplotype analyses with six tag SNPs indicated that a specific haplotype GCAACT, which harbors G80T G-allele and C921T C-allele, was significantly associated with AD (v 2 = 14.82, degrees of freedom (d.f.) = 1, P < 0.001), CD (v 2 = 9.19, d.f. = 1, P = 0.002) and OD (v 2 = 20.68, d.f. = 1, P < 0.001). Logistic regression analyses, with sex and age being considered, demonstrated that this haplotype had a risk effect on AD (P = 0.03, b = 1.86, odds ratio (OR) = 6.43) and especially on OD (P < 0.001, b = 3.92, OR = 50.57). Moreover, seven SNPs covering OPRK1 were examined in the majority of the above subjects (390 cases, including 327 AD, 177 CD and 97 OD subjects, and 358 controls). Although no significant differences in allele, genotype or haplotype frequency distributions were seen between cases and controls, a specific OPRK1 haplotype, GGCTTCT, was significantly associated with AD (v 2 = 8.12, d.f. = 1, P = 0.004). Logistic regression analyses also revealed its risk effect on AD (P = 0.009, b = 1.06, OR = 2.90). Population stratification artifact was not observed in the sample. Taken together, our findings supported a positive association between OPRD1 variants and SD, and a positive haplotypic association between OPRK1 and AD in EAs.

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Section: Discussionmentioning

confidence: 96%

“…14 Furthermore, several putative k-receptor agonists inhibit m-and d-receptor-dependent pharmacological actions, such as dopaminerelated hyperlocomotion. 15 Of interest, the k-receptor seems to mediate psychotomimetic effects. Agonists of the k-receptor have been shown to elicit dysphoric sensations.…”

Section: Introductionmentioning

confidence: 99%

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

et al. 2007

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“…This observation also supports our suggestion that mu receptor subtypes may not be involved in the opioid-related analgesic activities of the HPE and HSE. It has been demonstrated that administration of kappa agonists elicit sedative action in contrast to the stimulant effect of mu and deltaagonists on locomotor activities in mice (Iwamoto, 1981;Narita et al, 1993b;Vonvoigtlander et al, 1983). In the present study, both HPE and HSE were decreased the total number of locomotor activities in the activity cage and reduced the exploratory behavior in the holeboard tests.…”

Section: Discussionmentioning

confidence: 99%

Effects of hawthorn seed and pulp extracts on the central nervous system

Can

Özkay

Öztürk

et al. 2010

Pharmaceutical Biology

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“…A great deal of the difficulties in elucidating the effect of naloxone and of opioid agonists on locomotor behavior is certainly due to the significant controversy that has appeared in the literature regarding the contribution of each opioid receptor subtype to the locomotor stimulation induced by opioids in mice. A large number of studies have proposed that the opioid-induced increase of locomotor activity in mice is related to µ and δ, but not κ receptor stimulation (33)(34)(35), since κ agonists, in general, cause a decrease in locomotion, while µ and δ agonists increase it. The effects of these opioid agonists on locomotion have been attributed to a modulation of the dopaminergic mesolimbic and nigrostriatal pathways by opioid receptors (36)(37)(38).…”

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confidence: 99%

Antinociceptive effect of novel pyrazolines in mice

Tabarelli

Rubin

Berlese

et al. 2004

Braz J Med Biol Res

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The antinociceptive effect of six novel synthetic pyrazolines (3-ethoxymethyl-5-ethoxycarbonyl-1H-pyrazole (Pz 1) and its corresponding 1-substituted methyl (Pz 2) and phenyl (Pz 3) analogues, and 3-(1-ethoxyethyl)-5-ethoxycarbonyl-1H-pyrazole (Pz 4) and its corresponding 1-substituted methyl (Pz 5) and phenyl (Pz 6) analogues) was evaluated by the tail immersion test in adult male albino mice. The animals (N = 11-12 in each group) received vehicle (5% Tween 80, 10 ml/kg, sc) or 1.5 mmol/kg of each of the pyrazolines (Pz 1-Pz 6), sc. Fifteen, thirty and sixty minutes after drug administration, the mice were subjected to the tail immersion test. Thirty minutes after drug administration Pz 2 and Pz 3 increased tail withdrawal latency (vehicle = 3.4 ± 0.2; Pz 2 = 5.2 ± 0.4; Pz 3 = 5.9 ± 0.4 s; mean ± SEM), whereas the other pyrazolines did not present antinociceptive activity. Doseeffect curves (0.15 to 1.5 mmol/kg) were constructed for the bioactive pyrazolines. Pz 2 (1.5 mmol/kg, sc) impaired motor coordination in the rotarod and increased immobility in the open-field test. Pz 3 did not alter rotarod performance and spontaneous locomotion, but increased immobility in the open field at the dose of 1.5 mmol/kg. The involvement of opioid mechanisms in the pyrazoline-induced antinociception was investigated by pretreating the animals with naloxone (2.75 µmol/kg, sc). Naloxone prevented Pz 3-but not Pz 2-induced antinociception. Moreover, naloxone pretreatment did not alter Pz 3-induced immobility. We conclude that Pz 3-induced antinociception involves opioid mechanisms but this is not the case for Pz 2.

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The Cytosolic Acidification in Rat Parotid Cells Is Associated with an Increase in Cytosolic Ca2+ Concentration

Cited by 58 publications

References 39 publications

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk

Effects of hawthorn seed and pulp extracts on the central nervous system

Antinociceptive effect of novel pyrazolines in mice

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