The Cytotoxic Effect of Polygonium cognatum and Chemotherapeutic Effect of Doxorubicin on Glioblastoma Cells

Pehlivan, Melek; Çöven, Hatice İlayhan Karahan; Çerçi, Burcu; Eldem, Asli; Oz, Tuba; Savlak, Nazlı; Soyöz, Mustafa; Pirim, İbrahim

doi:10.5152/eurjther.2021.20085

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Pehlivan et al. [58] found that the IC 50 values were determined as 100 μg/mL for the methanolic extract of P. cognatum at 48 h for U87 glioblastoma cells by XTT analysis.…”

Section: Resultsmentioning

confidence: 99%

“…obtained that IC 50 values of P. cognatum plants collected from the wild flora of Sivas (ethanol extracts) were 53 μg/mL in MDA-MB-231 cell and > 1000 μg/mL in L929 cell for 24 h exposure according to XTT cytotoxicity analysis, and this study showed that human breast cancer cell line was found to be much more effective than mouse subcutaneous connective tissue cell line. Pehlivan et al [58] found that the IC 50 values were determined as 100 μg/mL for the methanolic extract of P. cognatum at 48 h for U87 glioblastoma cells by XTT analysis.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

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Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Akpınar,

Yıldırım Baştemur,

Bıçak

et al. 2023

J of Separation Science

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Polygonum cognatum Meissn, a perennial herbaceous belonging to the Polygonaceae family, is an aromatic plant. High‐performance liquid chromatography/diode array detector method was developed and validated for the phytochemical analysis of the plant. Also, various methods were used to investigate the antioxidant, antimicrobial, and cytotoxic activities of the methanolic extracts. Antioxidant activities were researched by 2,2′‐diphenyl‐1‐picrylhydrazyl and cupric reducing antioxidant capacity methods. Among the tested standard microbial strains, Candida albicans was found to be more sensitive with a 24.60 ± 0.55 mm inhibition zone according to the diffusion tests. In the microdilution tests, the minimum inhibitory concentration and minimum bactericidal/fungicidal concentration values were 4.75 and ≥ 4.75 mg/mL, respectively, for all tested pathogens. Human colon carcinoma cells were used to investigate cytotoxicity by using 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyl tetrazolium bromide analysis (IC50 = 2891 μg/mL for Plant A, IC50 = 3291 μg/mL for Plant B). Molecular docking and absorption, distribution, metabolism, excretion, and toxicity analysis were used to explain inhibition mechanisms of major phenolic compounds of plants against Tankyrase 1, Tankyrase 2 enzymes, and deoxyribonucleic acid gyrase subunit B and found compatible with experimental results.

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“…Pehlivan et al. [58] found that the IC 50 values were determined as 100 μg/mL for the methanolic extract of P. cognatum at 48 h for U87 glioblastoma cells by XTT analysis.…”

Section: Resultsmentioning

confidence: 99%

Section: Cytotoxic Activitymentioning

confidence: 99%

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Akpınar,

Yıldırım Baştemur,

Bıçak

et al. 2023

J of Separation Science

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show abstract

“…P. cognatum contains phenolic compounds, polyuronides, vitamin C, saponins and carotenoids. It has been demonstrated by various studies that it has antimicrobial, diuretic, antioxidant, anticancer and antidiabetic activities [19]- [21].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of Iron, Copper and Silver Nanoparticles Using Polygonum Cognatum and Tragopogon Porrifolius Extracts and Evaluation of Their Antimicrobial Potentials

KAPLAN,

GÖKŞEN TOSUN

2023

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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In this study, the biosynthesis of iron (Fe), copper (Cu) and silver (Ag) nanoparticles was aimed using aqueous extracts of Polygonum cognatum (P. cognatum) and Tragopogon porrifolius (T. porrifolius). The synthesized nanoparticles were characterized using UV/Vis spectroscopy, fourier transform infrared spectroscopy (FTIR) and dynamic light scattering technique (DLS). The antibacterial activity of the nanoparticles was analyzed against well-known pathogens Klebsiella pneumonia, Pseudomonas aeruginosa, Enterococcus faecalis and Staphylococcus aureus. In addition, the anti-fungal activity of the nanoparticles against Candida albicans and Candida utilis strains was evaluated. The obtained results showed that the synthesized nanoparticles have a moderate antimicrobial effect.

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Assessment of antimicrobial, anti-diabetic, anti-Alzheimer and anti-cancer properties, along with bioaccessibility and bioactive potential of Polygonum cognatum Meissn extracts from various cities in Türkiye

Erol,

Kutlu

2025

Food Bioscience

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The Cytotoxic Effect of Polygonium cognatum and Chemotherapeutic Effect of Doxorubicin on Glioblastoma Cells

Cited by 5 publications

References 20 publications

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Phytochemical profiling, in vitro biological activities, and in silico (molecular docking and absorption, distribution, metabolism, excretion, toxicity) studies of Polygonum cognatum Meissn

Biosynthesis of Iron, Copper and Silver Nanoparticles Using Polygonum Cognatum and Tragopogon Porrifolius Extracts and Evaluation of Their Antimicrobial Potentials

Assessment of antimicrobial, anti-diabetic, anti-Alzheimer and anti-cancer properties, along with bioaccessibility and bioactive potential of Polygonum cognatum Meissn extracts from various cities in Türkiye

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