The Cytotoxic Principles of Solanum incanum

Lin, Chun‐Nan; Lu, Chai-Ming; Cheng, Ming-Kung; Gan, Kim-Hong; Won, Shen‐Jeu

doi:10.1021/np50068a041

Cited by 73 publications

(35 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reliable criterion for judging the value of any anticancer drug is the prolongation of life span of the animal and disappearance of Leukemic cells from blood (Lin et al, 1988). In the present study, the total alkaloid fraction of methanolic extract of Solanum pseudocapsicum leaves was tested for its in-vivo antitumor activity against Dalton's Lymphoma Ascites model.…”

Section: Discussionmentioning

confidence: 99%

Antitumor activity of total alkaloid fraction of solanum pseudocapsicum leaves

Badami

Reddy

Kumar

et al. 2003

Phytotherapy Research

View full text Add to dashboard Cite

The total alkaloid fraction of the methanolic extract of Solanum pseudocapsicum leaves was tested for its in-vivo antitumor activity against Dalton's Lymphoma Ascites model in mice. The total alkaloid fraction at 2.5 and 5.0 mg/kg body weight doses exhibited antitumor activity as revealed by the significant increase in the mean survival time and the percentage increase in life span of tumor bearing mice. The antitumor activity observed may be due to its cytotoxic properties. However the treatment caused a significant decrease in the body weight below the normal indicating the toxicity of the treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Antitumor activity of total alkaloid fraction of solanum pseudocapsicum leaves

Badami

Reddy

Kumar

et al. 2003

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…It has broad bioactive use including antifungal, antiinflammatory, antiulceric, antihyperlipidemic, antihyperglycemic, and antitumorgenic activity (Yan et al, 2010;Liu, 1995;Gayathri et al, 2009 (Ma et al, 1986;Lin et al, 1988;Liu et al, 1994;Saraswat et al, 2000;Ovesna et al, 2004). However, the potential role of UA in liver regeneration has not been studied.…”

Section: Introductionmentioning

confidence: 99%

Ursolic acid enhances mouse liver regeneration after partial hepatectomy

Jin

et al. 2011

Pharmaceutical Biology

View full text Add to dashboard Cite

“…Free radicals and oxidative stress have been implicated in the pathogenesis of ethanol-induced liver injury in humans and experimental animals [2,3]. The most extensively studied aspect of free radical-induced liver injury is lipid peroxidation.…”

Section: Introductionmentioning

confidence: 99%

Hemidesmus indicus Protects against ethanol-induced liver toxicity

Saravanan

Nalini

2008

Cellular and Molecular Biology Letters

View full text Add to dashboard Cite

Alcoholic liver disease (ALD) is one of the most common diseases in modern society. A large number of studies are in progress aiming to identify natural substances that would be effective in reducing the severity of ALD. Although there are currently a number of drugs on the market, their long-term use can have numerous side effects. Hemidesmus indicus is an indigenous Ayurvedic medicinal plant used in soft drinks in India. In this study, we examined the effects of its ethanolic root extract on experimental liver damage in order to evaluate its hepatoprotective effects against hepatotoxicity induced in rats by ethanol at a dosage of 5 g/kg body weight for 60 days. The H. indicus root extract was given at a dose of 500 mg/kg body weight for the last 30 days of the experiment. The animals were monitored for food intake and weight gain. The liver was analysed for the degree of lipid peroxidation using thiobarbituric acid reactive substances (TBARS) and antioxidant status using the activities of glutathione-depedendant enzymes. The degree of liver damage was analysed using serum marker enzyme activities, the total protein, albumin, globulin, ceruloplasmin and liver glycogen contents, and the A/G ratio. The Fourier transform infrared spectra (FT-IR) of the liver tissues were recorded in the region of 4000-400 cm -1 . The ethanol-fed rats showed significantly elevated liver marker enzyme activities, lipid peroxidation levels and reduced antioxidant levels as compared to the control rats. Oral administration of H. indicus for the latter 30 days resulted in an increased food intake and weight gain, decreased TBARS levels, near normal levels of glutathione-dependent enzymes, increased total protein, albumin, globulin and liver glycogen contents, an increased A/G ratio, and decreased liver marker enzyme activities and ceruloplasmin levels. The relative intensity of the liver FT-IR bands for the experimental groups were found to be altered significantly (p < 0.05) compared to the control samples. For the group that had H. indicus co-administered with ethanol, the intensity of the bands was near normal. Moreover, the results of the FT-IR study correlated with our biochemical results.

show abstract

The Cytotoxic Principles of Solanum incanum

Cited by 73 publications

References 8 publications

Antitumor activity of total alkaloid fraction of solanum pseudocapsicum leaves

Antitumor activity of total alkaloid fraction of solanum pseudocapsicum leaves

Ursolic acid enhances mouse liver regeneration after partial hepatectomy

Hemidesmus indicus Protects against ethanol-induced liver toxicity

Contact Info

Product

Resources

About