The D allele of angiotensin-converting enzyme gene is associated with greater hemodynamic response to resistance exercises

Abstract

Hypothesis/introduction: The association of ACE I/D polymorphism and hemodynamic response to exercise have been limited to primarily aerobic exercises. We hypothesized that D allele carriers would show greater hemodynamic response to resistance exercise, as has been observed with aerobic. This study aimed to investigate the association of ACE I/D polymorphism and hemodynamic (blood pressure (BP), heart rate (HR) and rate-pressure product (RPP)) response to resistance exercise in young healthy subjects. Materials and methods: ACE I/D polymorphisms were studied by PCR analysis from 75 healthy men. Subjects completed a resistance exercise session of three sets of 10 knee extension repetitions with loads of 50, 75 and 100% of 10RM and two-minute rest intervals. Hemodynamic measures were recorded before and immediately after each set. Analysis of variance was used to identify significant differences among ACE genotypes. Results: ACE I/D polymorphism is associated with hemodynamic response to resistance exercise, as healthy subjects with ACE D allele were prone to higher responses. In addition, this phenotypic difference seems to be a load-dependent trend. Conclusion: ACE DD carriers exhibit greater heart work during resistance exercise. Future studies should focus on the influence of resistance training period with different workloads on the hemodynamic response in healthy individuals with different ACE genotypes.

Angiotensin-Converting Enzyme Related-Polymorphisms on Inflammation, Muscle and Myocardial Damage After a Marathon Race

“…The ACE D allele has been associated with greater muscle power phenotypes after resistance exercise (Erskine et al, 2014; Freire et al, 2015). In our study the muscle damage markers measured before the race and CK and LDH levels measured immediately after the race were also lower in DD homozygotes, similar to results previously reported (Amir et al, 2007).…”

Effects of Acute Aquatic High-Intensity Intermittent Exercise on Blood Pressure and Arterial Stiffness in Postmenopausal Women with Different ACE Genotypes

“…These findings are consistent with Freire et al (2015) who adopted 50%, 75%, and 100%10 RM strength exercises. Their results showed that the DD genotype had a significantly greater SBP incremental response immediately after each exercise than the II or ID genotype [ 37 ]. This result may be attributed to the higher concentration of ACE in the DD genotype and the release of ACE by exercise stimulation.…”

“…At present, few studies have explored the effects of ACE on PEH. Previous studies have shown that there was different blood pressure altered in the people with different ACE genes after exercise [ 34 , 37 , 38 ]. Freire et al (2015) found that the SBP of people with the DD genotype at a resting state was significantly higher than those with the II or ID genotype [ 37 ].…”

“…Previous studies have shown that there was different blood pressure altered in the people with different ACE genes after exercise [ 34 , 37 , 38 ]. Freire et al (2015) found that the SBP of people with the DD genotype at a resting state was significantly higher than those with the II or ID genotype [ 37 ]. It has also been found that resistance exercises significantly increased the SBP and DBP of people carrying the DD genotype [ 37 ].…”

“…Freire et al (2015) found that the SBP of people with the DD genotype at a resting state was significantly higher than those with the II or ID genotype [ 37 ]. It has also been found that resistance exercises significantly increased the SBP and DBP of people carrying the DD genotype [ 37 ]. Goessler et al (2015) confirmed that the SBP and DBP of people with the II and ID genotypes were significantly decreased 1 h after a single walk with 60–75% HRR while those of people carrying DD genotype did not change [ 34 ].…”