The D allele of angiotensin-converting enzyme gene is associated with a worse autonomic heart control in community-based older adults

Santos, Juleno Honorato Brito dos; Passos, R.S.; Freire, Ivna Vidal; Ribeiro, Ícaro José Santos; Oliveira, Alinne Alves; Casotti, Cézar Augusto; Alkahtani, Shaea; Barbosa, Ana Angélica Leal; Pereira, Rafael

doi:10.1016/j.exger.2021.111227

Cited by 6 publications

(5 citation statements)

References 40 publications

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“…Our data obtained along the TT-test indicated a progressive increase of the parameter V2, achieving higher values at CAF supplementation (PC and CC), when compared to placebo. These find suggest a progressive increase of an indicator of parasympathetic activity 17 .…”

Section: Discussionmentioning

confidence: 72%

“…The R-R dynamics were classified into three pattern families: (I) patterns with no variation (V0; all three symbols were equal); (II) patterns with one variation (V1; two consequent symbols were equal, and the remaining symbol was different); and (III) patterns with two unlike or like variations (V2; all of the symbols were different from the previous ones). The percentage of the patterns V0 was calculated as sympathetic modulation predominance, V1 reflects sympathetic and parasympathetic modulation, and the V2 calculated as a parasympathetic modulation as suggested by Santos et al 17 . The data (i.e., successive RR intervals) were transferred to a computer for analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies 15 , 16 investigated the impact of CAF on ANS through HRV, reporting HRV decrease with some doses, while different strategies could increase the HRV. Methodological aspects could explain divergent results, especially owing to complex HRV behavior during exercise, which could be minimized with appropriate mathematical methods to extract RR interval variability, as with non-linear methods 17 . Notwithstanding, lack of pattern of supplementation approach, including dose and selected strategy, also contribute to divergence in the issue of this study.…”

Section: Introductionmentioning

confidence: 99%

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Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Sampaio-Jorge

Morales

Pereira

et al. 2021

Sci Rep

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The present study was designed to investigate the effects of different caffeine dietary strategies to compare the impact on athletic performance and cardiac autonomic response. The order of the supplementation was randomly assigned: placebo(4-day)-placebo(acute)/PP, placebo(4-day)-caffeine(acute)/PC and caffeine(4-day)-caffeine(acute)/CC. Fourteen male recreationally-trained cyclists ingested capsules containing either placebo or caffeine (6 mg kg−1) for 4 days. On day 5 (acute), capsules containing placebo or caffeine (6 mg kg−1) were ingested 60 min before completing a 16 km time-trial (simulated cycling). CC and PC showed improvements in time (CC vs PP, Δ − 39.3 s and PC vs PP, Δ − 43.4 s; P = 0.00; ƞ2 = 0.33) and in output power (CC vs PP, Δ 5.55 w and PC vs PP, Δ 6.17 w; P = 0.00; ƞ2 = 0.30). At the final of the time-trial, CC and PC exhibited greater parasympathetic modulation (vagal tone) when compared to the PP condition (P < 0.00; ƞ2 = 0.92). Our study provided evidence that acute caffeine intake (6 mg∙kg−1) increased performance (time-trial) and demonstrated a relevant cardioprotective effect, through increased vagal tone.

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Section: Discussionmentioning

confidence: 72%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Sampaio-Jorge

Morales

Pereira

et al. 2021

Sci Rep

Self Cite

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“…The results are presented as the mean ± SD, mean difference between groups, and its 95% confidence interval (95% CI). The mean differences and their 95% CI values were reported and interpreted as a measure of the effect size, since this approach allows the identification of the direction and magnitude of the effect, justifying its use as an adequate effect size measure [ 34 ], as used by Dos Santos et al, [ 35 ]. All frequentist procedures were carried out in SPSS 21.0 (IBM-SPSS Inc., Chicago, IL, USA), and the significance level was set as p ≤ 0.05.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Heart Autonomic Control between Hemodynamically Stable and Unstable Patients during Hemodialysis Sessions: A Bayesian Approach

Oliveira

Costa

et al. 2023

Entropy

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Intradialytic hypotension is a common complication during hemodialysis sessions. The analysis of successive RR interval variability using nonlinear methods represents a promising tool for evaluating the cardiovascular response to acute volemic changes. Thus, the present study aims to compare the variability of successive RR intervals between hemodynamically stable (HS) and unstable (HU) patients during a hemodialysis session, through linear and nonlinear methods. Forty-six chronic kidney disease patients volunteered in this study. Successive RR intervals and blood pressures were recorded throughout the hemodialysis session. Hemodynamic stability was defined based on the delta of systolic blood pressure (higher SBP-lower SBP). The cutoff for hemodynamic stability was defined as 30 mm Hg, and patients were stratified as: HS ([n = 21]: ≤29.9 mm Hg) or HU ([n = 25]: ≥30 mm Hg). Linear methods (low-frequency [LFnu] and high-frequency [HFnu] spectra) and nonlinear methods (multiscale entropy [MSE] for Scales 1–20, and fuzzy entropy) were applied. The area under the MSE curve at Scales 1–5 (MSE1–5), 6–20 (MSE6–20), and 1–20 (MSE1–20) were also used as nonlinear parameters. Frequentist and Bayesian inferences were applied to compare HS and HU patients. The HS patients exhibited a significantly higher LFnu and lower HFnu. For MSE parameters, Scales 3–20 were significantly higher, as well as MSE1–5, MSE6–20, and MSE1–20 in HS, when compared to HU patients (p < 0.05). Regarding Bayesian inference, the spectral parameters demonstrated an anecdotal (65.9%) posterior probability favoring the alternative hypothesis, while MSE exhibited moderate to very strong probability (79.4 to 96.3%) at Scales 3–20, and MSE1–5, MSE6–20, and MSE1–20. HS patients exhibited a higher heart-rate complexity than HU patients. In addition, the MSE demonstrated a greater potential than spectral methods to differentiate variability patterns in successive RR intervals.

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“…However, family members have a similar level of ACE plasma, suggesting that the inter individual variability in the ACE plasma level is determined by genetic factors (Ahmad Yuso & Che Muhamed ,2021). Among several polymorphisms of the ACE gene, the ACE I/D gene polymorphism has a strong association with the ACE plasma level, which accounts for 47% of the overall phenotypic variance of the ACE activity (Dos Santos et al,2021) .…”

Section: Introductionmentioning

confidence: 99%

Effect of ACE I/D polymorphism in cardiovascular disease patients

Al-Bayati

Al-Nahi

2022

ijhs

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Cardiovascular diseases (CVD) are the cause of the highest mortality rate among noncommunicable diseases, Some of the main risk factors for CVD include smoking, hypertension, high body mass index, lipid metabolism disorders, and diabetes mellitus, according to emerging evidence, Genetics and polymorphisms are thought to play an important role in the occurrence and progression of CVD. A number of 100 subjects were involved in this investigation, 70 of them with CVDs and the other 30 healthy individuals were used as control. The study was conducted to find out the importance of ACE gene polymorphism and biochemical variables in CVDs patients. In addition, the study aimed to investigate the effect of gene polymorphism on CVDs. The comparisons between genotypic frequency of ACE gene polymorphism in control and CVDs patients showed a significant increase (p≤0.005) in DD, ID genotype in CVDs patients compared to control , where II genotype significant decreased in CVDs patients compared to control. Our results show insertion mutation at 550bp only in CVDs patients, this mutation not show in other research.

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The D allele of angiotensin-converting enzyme gene is associated with a worse autonomic heart control in community-based older adults

Cited by 6 publications

References 40 publications

Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Caffeine increases performance and leads to a cardioprotective effect during intense exercise in cyclists

Comparison of Heart Autonomic Control between Hemodynamically Stable and Unstable Patients during Hemodialysis Sessions: A Bayesian Approach

Effect of ACE I/D polymorphism in cardiovascular disease patients

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