2013
DOI: 10.1007/s00776-013-0414-1
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The D-repeat polymorphism in the ASPN gene and primary knee osteoarthritis in a Mexican mestizo population: a case–control study

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Cited by 11 publications
(15 citation statements)
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“…An association with D-repeat polymorphisms was also confirmed for knee OA in a Greek population 28,29 . Further, other alleles (D12, D15, or D16) were associated with OA either as a risk factor or a protective factor in Mexican 30 and Iranian 31 study populations. Despite positive associations found in some study populations, when data are stratified by ethnicity, the results of 26 were similar to those of a control population in Spain (42.2%/12.6%/25.5%) 25 , but different from those of a control population in Japan (64%/4.8%/4.5%) 22 .…”
Section: Involvement Of Asporin In Oa Pathogenesismentioning
confidence: 92%
“…An association with D-repeat polymorphisms was also confirmed for knee OA in a Greek population 28,29 . Further, other alleles (D12, D15, or D16) were associated with OA either as a risk factor or a protective factor in Mexican 30 and Iranian 31 study populations. Despite positive associations found in some study populations, when data are stratified by ethnicity, the results of 26 were similar to those of a control population in Spain (42.2%/12.6%/25.5%) 25 , but different from those of a control population in Japan (64%/4.8%/4.5%) 22 .…”
Section: Involvement Of Asporin In Oa Pathogenesismentioning
confidence: 92%
“…Similarly, Jazayeri et al found that D15 allele could be considered as a risk allele only for women in the Iranian population (OR = 1.73, 95% CI 1.01–2.94, P  < 0.05) [35]. Moreover, in Mexican Mestizo population, D16 allele was observed as a risk factor of KOA in females (OR = 2.226, 95% CI 1.064–3.151, P  < 0.03), whereas male carriers of D17 allele were more susceptible to KOA (OR = 3.803, 95% CI 1.010–14.317, P  < 0.05) [21]. There were a number of reasons for these confusing results.…”
Section: Discussionmentioning
confidence: 99%
“…Differences in inclusion criteria might be one of them. Some studies recruited KOA patients according to symptoms or radiographic evidence [13, 21, 35–38], whereas the others according to joint replacement [3234, 39]. Additionally, ethnic and gender differences might be another important reason as well.…”
Section: Discussionmentioning
confidence: 99%
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