The Dachsous/Fat/Four-Jointed Pathway Directs the Uniform Axial Orientation of Epithelial Cells in the Drosophila Abdomen

Mangione, Federica; Martı́n-Blanco, Enrique

doi:10.1016/j.celrep.2018.11.036

Cited by 24 publications

(33 citation statements)

References 83 publications

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“…Cell polarization dictates the direction of growth and might be coordinately affected by forces from neighboring cells. During expansion, we have found that cell elongation affects the orientation of anisotropic growth (Mangione & Martin-Blanco, 2018). While we did not analyze/discriminate stress polarity in a radial configuration, we found that the final global polarization of the abdominal epidermis responds to the axial alignment of histoblast orientation.…”

Section: Mechanical Coupling Of Growth and Deathmentioning

confidence: 75%

“…Myo-GFP transgenic pupae were used to visualize the cortex displacements. This constitutes an emerging property of the tissue, dictated by the activity of the Ft/Ds/Fj pathway, which define a patterned cell adhesiveness landscape (Mangione & Martin-Blanco, 2018). Scale bar = 15 lm.…”

Section: Of 15mentioning

confidence: 99%

“…While we did not analyze/discriminate stress polarity in a radial configuration, we found that the final global polarization of the abdominal epidermis responds to the axial alignment of histoblast orientation. This constitutes an emerging property of the tissue, dictated by the activity of the Ft/Ds/Fj pathway, which define a patterned cell adhesiveness landscape (Mangione & Martin-Blanco, 2018). Whether this is linked to mechanical efforts, remains to be explored.…”

Section: Mechanical Coupling Of Growth and Deathmentioning

confidence: 99%

“…Pupae carrying the ZCL2207 septate junction marker (Mangione & Martin-Blanco, 2018) were removed from the pupal case and placed on a drop of Voltalef 10S halocarbon oil (VWR International) in a glass-bottom culture plate (MatTek) with a wet piece of paper to avoid specimen desiccation. Pupae were oriented to monitor the 3 rd or 4 th ventral nests at mounting.…”

Section: Live Imaging and Processingmentioning

confidence: 99%

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Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila

et al. 2019

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During development, cells coordinate to organize in coherent structures. Although it is now well established that physical forces are essential for implementing this coordination, the instructive roles of mechanical inputs are not clear. Here, we show that the replacement of the larval epithelia by the adult one in Drosophila demands the coordinated exchange of mechanical signals between two cell types, the histoblasts (adult precursors) organized in nests and the surrounding larval epidermal cells (LECs). An increasing stress gradient develops from the center of the nests toward the LECs as a result of the forces generated by histoblasts as they proliferate and by the LECs as they delaminate (push/pull coordination). This asymmetric radial coordination of expansive and contractile activities contributes to epithelial replacement. Our analyses support a model in which cell-cell mechanical communication is sufficient for the rearrangements that implement epithelial morphogenesis.

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Section: Mechanical Coupling Of Growth and Deathmentioning

confidence: 75%

Section: Of 15mentioning

confidence: 99%

Section: Mechanical Coupling Of Growth and Deathmentioning

confidence: 99%

Section: Live Imaging and Processingmentioning

confidence: 99%

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Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila

et al. 2019

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“…They subsequently developed an elegant and minimal mechanical model for tissue dynamics that captures the essential physics of this morphogenetic process. Finally, Enrique Martin-Blanco (CSIC, Barcelona, Spain) discussed tissue replacement during metamorphosis, detailing the mechanical cell behaviours and molecular pathways that allow newly formed adult epithelial cells, generated by histoblasts, to invade and replace the larval epithelium (Ninov et al, 2007;Ninov et al, 2010;Mangione et al, 2018).…”

Section: Emergent Properties and Self-organization: From Molecules Tomentioning

confidence: 99%

On growth and force: mechanical forces in development

Hallou

Brunet

2020

Development

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The EMBO/EMBL Symposium "Mechanical Forces in Development" was held in Heidelberg, Germany, on 3-6 July 2019. This interdisciplinary symposium brought together an impressive and diverse line-up of speakers seeking to address the origin and role of mechanical forces in development. Emphasising the importance of integrative approaches and theoretical simulations to obtain comprehensive mechanistic insights on complex morphogenetic processes, the meeting provided an ideal platform to discuss the concepts and methods of developmental mechanobiology in an era of fast technical and conceptual progress. Here, we summarise the concepts and findings discussed during the meeting, as well as the agenda it sets for the future of developmental mechanobiology.

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Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure

Engelhardt

Martyr

Niswander

2022

WIREs Mechanisms of Disease

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Neural tube closure (NTC) is crucial for proper development of the brain and spinal cord and requires precise morphogenesis from a sheet of cells to an intact three‐dimensional structure. NTC is dependent on successful regulation of hundreds of genes, a myriad of signaling pathways, concentration gradients, and is influenced by epigenetic and environmental cues. Failure of NTC is termed a neural tube defect (NTD) and is a leading class of congenital defects in the United States and worldwide. Though NTDs are all defined as incomplete closure of the neural tube, the pathogenesis of an NTD determines the type, severity, positioning, and accompanying phenotypes. In this review, we survey pathogenesis of NTDs relating to disruption of cellular processes arising from genetic mutations, altered epigenetic regulation, and environmental influences by micronutrients and maternal condition. This article is categorized under: Congenital Diseases > Genetics/Genomics/Epigenetics Neurological Diseases > Genetics/Genomics/Epigenetics Neurological Diseases > Stem Cells and Development

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The Dachsous/Fat/Four-Jointed Pathway Directs the Uniform Axial Orientation of Epithelial Cells in the Drosophila Abdomen

Cited by 24 publications

References 83 publications

Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila

Mechanical coordination is sufficient to promote tissue replacement during metamorphosis in Drosophila

On growth and force: mechanical forces in development

Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure

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