The Dalila effect: C57BL6 mice barber whiskers by plucking

Sarna, Justyna R.

doi:10.1016/s0166-4328(99)00137-0

Cited by 116 publications

(79 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In most cases, it affects whiskers, a crucial sensor system of external information in mice. However, an abnormal barbering conduct, as seen in PK −/− /Tau vlw mice [25], may be due to a pathological neurobiological status in mice and a compulsive behavior because it represents a part of the waking activity of the mice [33]. This PK −/− /Tau vlw model showed an elevated level of self-injured wounds on the front of the face, due to their compulsive behavior and repetitive selfscratching [25].…”

Section: Self-injurious Behaviormentioning

confidence: 84%

Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

Casarejos

Perucho

Gómez

et al. 2013

JAD

111

View full text Add to dashboard Cite

Abstract. Cannabinoids are neuroprotective in models of neurodegenerative dementias. Their effects are mostly mediated through CB1 and CB2 receptor-dependent modulation of excitotoxicity, inflammation, oxidative stress, and other processes. We tested the effects of Sativex ® , a mixture of 9 -tetrahydrocannabinol and cannabidiol, acting on both CB1 and CB2 receptors, in parkin-null, human tau overexpressing (PK −/− /Tau VLW ) mice, a model of complex frontotemporal dementia, parkinsonism, and lower motor neuron disease. The animals received Sativex ® , 4.63 mg/kg, ip, daily, for one month, at six months of age, at the onset of the clinical symptoms. We evaluated the effects of Sativex ® on behavior, dopamine neurotransmission, glial activation, redox state, mitochondrial activity, and deposition of abnormal proteins. PK −/− /Tau VLW mice developed the neurological deficits, but those treated with Sativex ® showed less abnormal behaviors related to stress, less auto and hetero-aggression, and less stereotypy. Sativex ® significantly reduced the intraneuronal, MAO-related free radicals produced during dopamine metabolism in the limbic system. Sativex ® also decreased gliosis in cortex and hippocampus, increased the ratio reduced/oxidized glutathione in the limbic system, reduced the levels of iNOS, and increased those of complex IV in the cerebral cortex. With regard to tau and amyloid pathology, Sativex ® reduced the deposition of both in the hippocampus and cerebral cortex of PK −/− /Tau VLW mice and increased autophagy. Sativex ® , even after a short administration in animals with present behavioral and pathological abnormalities, improves the phenotype, the oxidative stress, and the deposition of proteins in PK −/− /Tau VLW mice, a model of complex neurodegenerative disorders.

show abstract

Section: Self-injurious Behaviormentioning

confidence: 84%

Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

Casarejos

Perucho

Gómez

et al. 2013

JAD

111

View full text Add to dashboard Cite

show abstract

“…Grb10 heterozygous paternal knockout mice are less likely to back down in direct confrontation with an unfamiliar mouse in the tube test compared with WT littermates (6). Facial barbering is a dominance-related behavior that occurs during cogrooming, where a dominant mouse barbers other passive mice (52). Cagemates of paternal knockout mice had barbered whiskers, which regrew when caged with only WT littermates.…”

Section: Paternal Grb10 Expression In Neurons Affects Behaviormentioning

confidence: 99%

Tissue-specific regulation and function of Grb10 during growth and neuronal commitment

Plasschaert

Bartolomei

2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Growth-factor receptor bound protein 10 (Grb10) is a signal adapter protein encoded by an imprinted gene that has roles in growth control, cellular proliferation, and insulin signaling. Additionally, Grb10 is critical for the normal behavior of the adult mouse. These functions are paralleled by Grb10’s unique tissue-specific imprinted expression; the paternal copy of Grb10 is expressed in a subset of neurons whereas the maternal copy is expressed in most other adult tissues in the mouse. The mechanism that underlies this switch between maternal and paternal expression is still unclear, as is the role for paternally expressed Grb10 in neurons. Here, we review recent work and present complementary data that contribute to the understanding of Grb10 gene regulation and function, with specific emphasis on growth and neuronal development. Additionally, we show that in vitro differentiation of mouse embryonic stem cells into alpha motor neurons recapitulates the switch from maternal to paternal expression observed during neuronal development in vivo. We postulate that this switch in allele-specific expression is related to the functional role of Grb10 in motor neurons and other neuronal tissues.

show abstract

“…However, the stereotypies and barbering (whisker-plucking) prevalent in some mice (e.g. Nevison et al, 1999a;Sarna et al, 2000) do raise welfare concerns, as do the poor breeding performance and high sensitivity to environmental change seen in some strains (e.g. A/Sn; A. Peters, personal communication).…”

Section: Mouse Behavioural Biology and Welfare In The Laboratorymentioning

confidence: 99%

From house mouse to mouse house: the behavioural biology of free-living Mus musculus and its implications in the laboratory

Latham

Mason

2004

Applied Animal Behaviour Science

293

236

View full text Add to dashboard Cite

Understanding a species' behaviour in natural conditions can give insights into its development, responses and welfare in captivity. Here, we review research and pest control literatures on the free-living house mouse (Mus musculus), analysing its sensory world, developmental processes and behaviour to suggest how laboratory environments might affect mouse welfare, normalcy, test design, and behaviour. Mouse development from foetus to weaning is influenced by prenatal stress and nutrient levels, and post-natal litter size and other factors affecting maternal care, all with lasting effects on adult bodyweight, aggression, activity levels, stress responsiveness and masculinisation. These influences may well be important in the laboratory, for example unwittingly differing between facilities leading to site-differences in phenotype. Murine senses are dominated by olfactory, auditory and tactile cues. Their hearing extends into the ultrasonic, and vision, from mid-range wavelengths to the ultraviolet. In mouse facilities, behaviour and welfare may therefore also be affected by sensory stimuli unnoticed by humans. The physical and social environment and behaviour of wild mice differ greatly from those of laboratory mice. Dispersal age varies with resource-levels and social cues, and mice often either live alone or in family groups. Mice occupy territories/ranges measuring a few square meters to several square kilometers, and which allow running, climbing, and burrowing. Mice are often active during dawn/dusk, and spend their time patrolling their territories, investigating neighbours' odour cues, foraging, finding mates and rearing litters. The potential impact of these many differences and restrictions on laboratory mouse development, normalcy and welfare has only begun to be explored.

show abstract

The Dalila effect: C57BL6 mice barber whiskers by plucking

Cited by 116 publications

References 16 publications

Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

Natural Cannabinoids Improve Dopamine Neurotransmission and Tau and Amyloid Pathology in a Mouse Model of Tauopathy

Tissue-specific regulation and function of Grb10 during growth and neuronal commitment

From house mouse to mouse house: the behavioural biology of free-living Mus musculus and its implications in the laboratory

Contact Info

Product

Resources

About