The Danger of Not Treating Parkinson Disease Psychosis—Reply

Weintraub, Daniel; Kales, Helen C.; Marras, Connie

doi:10.1001/jamaneurol.2016.2274

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…This is not possible in current clinical practice that is based on clinically important but post-hoc interviews between physician and patient, often about hallucinations that have occurred many days or weeks ago and that many patients hesitate to speak about (18). The detection of specific behavioral and imaging changes associated with specific hallucinatory states that are observed online during the robotic procedure might improve the quantification and prediction of a patient's proneness to PH, potentially for other minor and traditional hallucinations and psychosis, and may facilitate targeted pharmacological interventions that limit side effects (64).…”

Section: Discussionmentioning

confidence: 99%

Robot-induced hallucinations in Parkinson’s disease depend on altered sensorimotor processing in fronto-temporal network

et al. 2021

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Hallucinations in Parkinson’s disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the induction of presence hallucinations (PHs) and the characterization of a subgroup of patients with PD with enhanced sensitivity for conflicting sensorimotor stimulation and robot-induced PH. We next identify the fronto-temporal network of PH by combining MR-compatible robotics (and sensorimotor stimulation in healthy participants) and lesion network mapping (neurological patients without PD). This PH-network was selectively disrupted in an additional and independent cohort of patients with PD, predicted the presence of symptomatic PH, and associated with cognitive decline. These robotics-neuroimaging findings extend existing sensorimotor hallucination models to PD and reveal the pathological cortical sensorimotor processes of PH in PD, potentially indicating a more severe form of PD that has been associated with psychosis and cognitive decline.

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Section: Discussionmentioning

confidence: 99%