The Danish High-Risk and Resilience Study—VIA 15 – A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls

Abstract

BackgroundChildren born to parents with severe mental illness have gained more attention during the last decades because of increasing evidence documenting that these children constitute a population with an increased risk of developing mental illness and other negative life outcomes. Because of high-quality research with cohorts of offspring with familial risk and increased knowledge about gene–environment interactions, early interventions and preventive strategies are now being developed all over the world. Adolescence is a period characterized by massive changes, both in terms of physical, neurologic, psychological, social, and behavioral aspects. It is also the period of life with the highest risk of experiencing onset of a mental disorder. Therefore, investigating the impact of various risk and resilience factors in adolescence is important.MethodsThe Danish High-Risk and Resilience Study started data collection in 2012, where 522 7-year-old children were enrolled in the first wave of the study, the VIA 7 study. The cohort was identified through Danish registers based on diagnoses of the parents. A total of 202 children had a parent diagnosed with schizophrenia, 120 children had a parent diagnosed with bipolar disorder, and 200 children had parents without these diagnoses. At age 11 years, all children were assessed for the second time in the VIA 11 study, with a follow-up retention rate of 89%. A comprehensive assessment battery covering domains of psychopathology, neurocognition, social cognition and behavior, motor development and physical health, genetic analyses, attachment, stress, parental functioning, and home environment was carried out at each wave. Magnetic resonance imaging scans of the brain and electroencephalograms were included from age 11 years. This study protocol describes the third wave of assessment, the VIA 15 study, participants being 15 years of age and the full, 3-day-long assessment battery this time including also risk behavior, magnetoencephalography, sleep, and a white noise paradigm. Data collection started on May 1, 2021.DiscussionWe will discuss the importance of longitudinal studies and cross-sectional data collection and how studies like this may inform us about unmet needs and windows of opportunity for future preventive interventions, early illness identification, and treatment in the future.

Executive Control and Associated Brain Activity in Children With Familial High-Risk of Schizophrenia or Bipolar Disorder: A Danish Register-based Study

“…Longitudinal studies investigating the developmental trajectories of possible cognitive and/or neurobiological deficits are warranted to assess the state or trait nature of the (possible) early endophenotypic markers for SZ and BP. Our follow-up study, The VIA 15 study, 60 will enable us to explore these aspects. Another important point is that children at FHR-SZ and FHR-BP in the present study were grouped based on the parent’s psychiatric history.…”

A Bio-Social Model during the First 1000 Days Optimizes Healthcare for Children with Developmental Disabilities

“…This longitudinal cohort correlated neuron-specific genetic markers to quantitative MRI profiles. Similar methodology has been reported in Danish longitudinal imaging-genetic cohort comprised of individuals who have familial risk for schizophrenia and bipolar disease [ 51 ]. Both studies suggest that effective preventive treatment strategies can be achieved before mental health disorders are expressed.…”