The Dartmouth Center for Cancer Nanotechnology Excellence: Magnetic Hyperthermia

Baker, I.; Fiering, Steven; Griswold, Karl E.; Hoopes, P. Jack; Kekalo, Katerina; Ndong, Christian; Paulsen, Keith D.; Petryk, Alicia A.; Pogue, Brian W.; Shubitidze, Fridon; Weaver, John B.

doi:10.2217/nnm.15.64

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…Moreover, the overheating of cells can stimulate the anti-cancer immune response. Baker et al showed an increased response involving T lymphocytes in murine melanoma tissue following hyperthermia treatment [79]. In our studies, a substantial increase in temperature was observed for the composite sphere sample under the influence of an alternating magnetic field.…”

Section: Discussionsupporting

confidence: 62%

Hyperthermia treatment of cancer cells by the application of targeted silk/iron oxide composite spheres

Kucharczyk

Kaczmarek

Józefczak

et al. 2021

Materials Science and Engineering: C

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Magnetic iron oxide nanoparticles (IONPs) are one of the most extensively studied materials for theranostic applications. IONPs can be used for magnetic resonance imaging (MRI), delivery of therapeutics, and hyperthermia treatment. Silk is a biocompatible material and can be used for biomedical applications. Previously, we produced spheres made of H2.1MS1 bioengineered silk that specifically carried a drug to the Her2-overexpressing cancer cells. To confer biocompatibility and targeting properties to IONPs, we blended these particles with bioengineered spider silks.Three bioengineered silks (MS1Fe1, MS1Fe2, and MS1Fe1Fe2) functionalized with the adhesion peptides F1 and F2, were constructed and investigated to form the composite spheres with IONPs carrying a positive or negative charge. Due to its highest IONP content, MS1Fe1 silk was used to produce spheres from the H2.1MS1:MS1Fe silk blend to obtain a carrier with cell-targeting properties. Composite H2.1MS1:MS1Fe1/IONP spheres made of silks blended at different ratios were obtained. Although the increased content of MS1Fe1 silk in particles resulted in an increased affinity of the spheres to IONPs, it decreased the binding of the composite particles to cancer cells. The H2.1MS1:MS1Fe1 particles prepared at a ratio of 8:2 and loaded with IONPs exhibited the ability to bind to the targeted cancer cells similar to the control spheres without IONPs. Moreover, when exposed to the alternating magnetic field, these particles generated 2.5 times higher heat. They caused an almost three times higher percentage of apoptosis in cancer cells than the control particles.The blending of silks enabled the generation of cancer-targeting spheres with a high affinity for iron oxide nanoparticles, which can be used for anti-cancer hyperthermia therapy.

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Section: Discussionsupporting

confidence: 62%

Hyperthermia treatment of cancer cells by the application of targeted silk/iron oxide composite spheres

Kucharczyk

Kaczmarek

Józefczak

et al. 2021

Materials Science and Engineering: C

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“…Magnetic iron oxide nanoparticles (MNPs) have demonstrated utility in biomedical diagnosis and therapy because they display generally favorable biocompatibility and varied responsiveness to magnetic fields 1 – 10 . The search for nanoparticle constructs that preferentially accumulate in cancer tumors or cancer cells, after systemic delivery, remains an area of active research 11 – 15 . A successful strategy to develop selective targeting however requires knowledge of the relationship between nanoparticle structure and the resulting biologic activity between the physicochemical properties of nanoparticles and their impact on biological processes that affect the nanoparticle distribution throughout tissues and organs 16 .…”

Section: Introductionmentioning

confidence: 99%

Physical characterization and in vivo organ distribution of coated iron oxide nanoparticles

Sharma

Cornejo

Mihalic

et al. 2018

Sci Rep

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Citrate-stabilized iron oxide magnetic nanoparticles (MNPs) were coated with one of carboxymethyl dextran (CM-dextran), polyethylene glycol-polyethylene imine (PEG-PEI), methoxy-PEG-phosphate+rutin, or dextran. They were characterized for size, zeta potential, hysteresis heating in an alternating magnetic field, dynamic magnetic susceptibility, and examined for their distribution in mouse organs following intravenous delivery. Except for PEG-PEI-coated nanoparticles, all coated nanoparticles had a negative zeta potential at physiological pH. Nanoparticle sizing by dynamic light scattering revealed an increased nanoparticle hydrodynamic diameter upon coating. Magnetic hysteresis heating changed little with coating; however, the larger particles demonstrated significant shifts of the peak of complex magnetic susceptibility to lower frequency. 48 hours following intravenous injection of nanoparticles, mice were sacrificed and tissues were collected to measure iron concentration. Iron deposition from nanoparticles possessing a negative surface potential was observed to have highest accumulation in livers and spleens. In contrast, iron deposition from positively charged PEG-PEI-coated nanoparticles was observed to have highest concentration in lungs. These preliminary results suggest a complex interplay between nanoparticle size and charge determines organ distribution of systemically-delivered iron oxide magnetic nanoparticles.

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“…Referring to the studies that investigated a mouse model of melanoma, raising the temperature of tissue significantly improved the immune response with the participation of T lymphocytes. This therapy was applied before surgical resection and was directed at protecting against recurrences of tumors after removal and at helping to eliminate metastases [ 74 ].…”

Section: Summary Of Clinical Applications Of Spionsmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles—Current and Prospective Medical Applications

et al. 2019

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The recent, fast development of nanotechnology is reflected in the medical sciences. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are an excellent example. Thanks to their superparamagnetic properties, SPIONs have found application in Magnetic Resonance Imaging (MRI) and magnetic hyperthermia. Unlike bulk iron, SPIONs do not have remnant magnetization in the absence of the external magnetic field; therefore, a precise remote control over their action is possible. This makes them also useful as a component of the advanced drug delivery systems. Due to their easy synthesis, biocompatibility, multifunctionality, and possibility of further surface modification with various chemical agents, SPIONs could support many fields of medicine. SPIONs have also some disadvantages, such as their high uptake by macrophages. Nevertheless, based on the ongoing studies, they seem to be very promising in oncological therapy (especially in the brain, breast, prostate, and pancreatic tumors). The main goal of our paper is, therefore, to present the basic properties of SPIONs, to discuss their current role in medicine, and to review their applications in order to inspire future developments of new, improved SPION systems.

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The Dartmouth Center for Cancer Nanotechnology Excellence: Magnetic Hyperthermia

Cited by 3 publications

References 37 publications

Hyperthermia treatment of cancer cells by the application of targeted silk/iron oxide composite spheres

Hyperthermia treatment of cancer cells by the application of targeted silk/iron oxide composite spheres

Physical characterization and in vivo organ distribution of coated iron oxide nanoparticles

Superparamagnetic Iron Oxide Nanoparticles—Current and Prospective Medical Applications

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