The DATAC study: a new growth database. Description of the epidemiology, diagnosis and therapeutic attitude in a group of Spanish children with short stature

Abstract

The baseline characteristics of the population to be treated with rhGH were similar to those reported in other growth databases. Delayed age at treatment initiation should increase the awareness of these disorders among general paediatricians and entice them to refer children suspected of having these disorders to a specialist.

Impact of adherence on growth response during the first 2 years of growth hormone treatment

“…When considering the information presented above, it becomes apparent that the importance of adherence in the second year of treatment must be assessed and demonstrated, because that's when it starts to decrease. In cases where adherence shows insufficient variation (as is suspected with the use of electronic administering devices, and when prescriptions are more recent), the assessment becomes even more complex, further demonstrating the need for adherence to be explored and examined [9].…”

“…Moreover, the significant variability in methods of detection and definitions of adherence utilized in studies must also be considered [8]. Newly available electronic or automatic administering devices are quickly becoming a highly useful tool in monitoring adherence to rhGH treatment [9]. Adherence data for patients using the EasyPod TM electronic device are both more accurate and easier to obtain than pharmacy dispensing data.…”

“…Adherence data for patients using the EasyPod TM electronic device are both more accurate and easier to obtain than pharmacy dispensing data. These developments facilitate the early detection of suboptimal compliance to treatment, allowing these problems to be corrected as soon as they occur [9].…”