The Dawning of the “Zinc Era” in the Treatment of Pediatric Acute Gastroenteritis Worldwide?

Canani, Roberto Berni; Ruotolo, S.

doi:10.1097/01.mpg.0000214159.60445.9a

Cited by 17 publications

(11 citation statements)

References 18 publications

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“…These findings are in line with meta-analyses showing that Zn 2 + supplementation significantly reduced the severity and the duration of acute diarrhea in children, most of whom lived in developing countries where Zn 2 + deficiency is common [12,13]. It can limit the intestinal fluid loss that occurs consequent to stimulation of the main intracellular pathways by the leading diarrhea-inducing pathogens [15][16][17]. It can limit the intestinal fluid loss that occurs consequent to stimulation of the main intracellular pathways by the leading diarrhea-inducing pathogens [15][16][17].…”

Section: Discussionsupporting

confidence: 82%

Acceptability and efficacy of a gel hypotonic oral rehydration solution in children with acute gastroenteritis

Passariello

Nocerino²,

Terrin

et al. 2015

European Journal of Gastroenterology &Amp; Hepatology

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Section: Discussionsupporting

confidence: 82%

Acceptability and efficacy of a gel hypotonic oral rehydration solution in children with acute gastroenteritis

Passariello

Nocerino²,

Terrin

et al. 2015

European Journal of Gastroenterology &Amp; Hepatology

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“…The dietary recommendations for preterm neonates suggest 1.1-2 mg $ kg Zn 21 $ d 21 (29). We used higher zinc doses; the use of zinc doses above the dietary guidance level is an emerging research area in pediatric nutrition (10,16). Many studies suggest that 10-20 mg Zn/d is able to limit the risk of infections in children (40)(41)(42).…”

Section: Discussionmentioning

confidence: 99%

Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

Terrin¹,

Canani²,

Passariello³

et al. 2013

The American Journal of Clinical Nutrition

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Background: Zinc plays a pivotal role in the pathogenesis of many diseases and in body growth. Preterm neonates have high zinc requirements. Objective: The objective of the study was to investigate the efficacy of zinc supplementation in reducing morbidity and mortality in preterm neonates and to promote growth. Design: This was a prospective, double-blind, randomized controlled study of very-low-birth-weight preterm neonates randomly allocated on the seventh day of life to receive (zinc group) or not receive (control group) oral zinc supplementation. Total prescribed zinc intake ranged from 9.7 to 10.7 mg/d in the zinc group and from 1.3 to 1.4 mg/d in the placebo control group. The main endpoint was the rate of neonates with $1 of the following morbidities: lateonset sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, periventricular leucomalacia, and retinopathy of prematurity. Secondary outcomes were mortality and body growth. Results: We enrolled 97 neonates in the zinc group and 96 in the control group. Morbidities were significantly lower in the zinc group (26.8% compared with 41.7%; P = 0.030). The occurrence of necrotizing enterocolitis was significantly higher in the control group (6.3% compared with 0%; P = 0.014). Mortality risk was higher in the placebo control group (RR: 2.37; 95% CI: 1.08, 5.18; P = 0.006). Daily weight gain was similar in the zinc (18.2 6 5.6 g $ kg 21 $ d 21 ) and control (17.0 6 8.7 g $ kg 21 $ d 21

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“…7 The exclusion criteria were: severely malnourished children (2nd and 3rd degree malnutrition defined according to the criteria described by Waterlow 8 ), antibiotic treatment during the preceding 7 days, known chronic uncontrolled intestinal disease such as celiac disease, pancreatic insufficiency, parasitic infestations, and bacterial diarrhea suspected by the presence of leukocyte and erythrocyte in stool examination in 2-3 hours of admission. All patients that were mild and moderately dehydrated 9 were treated according to the World Health Organization recommendations with ORS and zinc supplements (10 mg/day in infants ≤ 6 months and 20 mg/day in patients > 6 months 10 ). Patients were randomized according to their patient ID number and enrolled in 2 groups.…”

Section: Methodsmentioning

confidence: 99%

Clinical Efficacy Comparison of Saccharomyces boulardii and Yogurt Fluid in Acute Non-Bloody Diarrhea in Children: A Randomized, Controlled, Open Label Study

Eren¹,

Dinleyici²,

Vandenplas³

2010

The American Society of Tropical Medicine and Hygiene

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The purpose of this trial is to evaluate the clinical efficacy and cost/effectiveness of Saccharomyces boulardii compared with yogurt fluid (YF) in acute non-bloody diarrhea in children. This randomized, prospective open-label clinical trial includes 55 children (36 boys, 19 girls; mean age 21.2 ± 28.2 months). Group A (N = 28) received lyophilized S. boulardii and group B (N = 27) received YF. The duration of diarrhea was shorter with S. boulardii but the hospital stay was reduced with YF, although these differences were not significant. However, diarrhea had resolved in significantly more children on day 3 in the S. boulardii group (48.5% versus 25.5%; P < 0.05). In outpatient cases, yogurt treatment was cheaper than S. boulardii whereas in hospitalized patients, treatment cost was similar. In conclusion, the effect of daily freshly prepared YF was comparable to S. boulardii in the treatment of acute non-bloody diarrhea in children. The duration of diarrhea was shorter in the S. boulardii group, expressed as a significantly higher number of patients with normal stools on day 3.

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The Dawning of the “Zinc Era” in the Treatment of Pediatric Acute Gastroenteritis Worldwide?

Cited by 17 publications

References 18 publications

Acceptability and efficacy of a gel hypotonic oral rehydration solution in children with acute gastroenteritis

Acceptability and efficacy of a gel hypotonic oral rehydration solution in children with acute gastroenteritis

Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

Clinical Efficacy Comparison of Saccharomyces boulardii and Yogurt Fluid in Acute Non-Bloody Diarrhea in Children: A Randomized, Controlled, Open Label Study

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